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Index > Protein center > Itgal(Gene name) > Mouse
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  • Itgal (Gene name),
  • Integrin alpha-L (Protein name ),  ITAL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Itgal(Lfa-1;Ly-15);
    Protein name:
    Integrin alpha-L;
    Alternative:
    Leukocyte adhesion glycoprotein LFA-1 alpha chain(LFA-1A);CD11 antigen-like family member A;Lymphocyte antigen 15(Ly-15);Leukocyte function-associated molecule 1 alpha chain;
    CD:
    CD11a;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
    Function:
    Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1163
    Sequence:
    50:
    MSFRIAGPRL | LLLGLQLFAK | AWSYNLDTRP | TQSFLAQAGR | HFGYQVLQIE | 
    100:
    DGVVVGAPGE | GDNTGGLYHC | RTSSEFCQPV | SLHGSNHTSK | YLGMTLATDA | 
    150:
    AKGSLLACDP | GLSRTCDQNT | YLSGLCYLFP | QSLEGPMLQN | RPAYQECMKG | 
    200:
    KVDLVFLFDG | SQSLDRKDFE | KILEFMKDVM | RKLSNTSYQF | AAVQFSTDCR | 
    250:
    TEFTFLDYVK | QNKNPDVLLG | SVQPMFLLTN | TFRAINYVVA | HVFKEESGAR | 
    300:
    PDATKVLVII | TDGEASDKGN | ISAAHDITRY | IIGIGKHFVS | VQKQKTLHIF | 
    350:
    ASEPVEEFVK | ILDTFEKLKD | LFTDLQRRIY | AIEGTNRQDL | TSFNMELSSS | 
    400:
    GISADLSKGH | AVVGAVGAKD | WAGGFLDLRE | DLQGATFVGQ | EPLTSDVRGG | 
    450:
    YLGYTVAWMT | SRSSRPLLAA | GAPRYQHVGQ | VLLFQAPEAG | GRWNQTQKIE | 
    500:
    GTQIGSYFGG | ELCSVDLDQD | GEAELLLIGA | PLFFGEQRGG | RVFTYQRRQS | 
    550:
    LFEMVSELQG | DPGYPLGRFG | AAITALTDIN | GDRLTDVAVG | APLEEQGAVY | 
    600:
    IFNGKPGGLS | PQPSQRIQGA | QVFPGIRWFG | RSIHGVKDLG | GDRLADVVVG | 
    650:
    AEGRVVVLSS | RPVVDVVTEL | SFSPEEIPVH | EVECSYSARE | EQKHGVKLKA | 
    700:
    CFRIKPLTPQ | FQGRLLANLS | YTLQLDGHRM | RSRGLFPDGS | HELSGNTSIT | 
    750:
    PDKSCLDFHF | HFPICIQDLI | SPINVSLNFS | LLEEEGTPRD | QKGRAMQPIL | 
    800:
    RPSIHTVTKE | IPFEKNCGED | KKCEANLTLS | SPARSGPLRL | MSSASLAVEW | 
    850:
    TLSNSGEDAY | WVRLDLDFPR | GLSFRKVEML | QPHSRMPVSC | EELTEGSSLL | 
    900:
    TKTLKCNVSS | PIFKAGQEVS | LQVMFNTLLN | SSWEDFVELN | GTVHCENENS | 
    950:
    SLQEDNSAAT | HIPVLYPVNI | LTKEQENSTL | YISFTPKGPK | TQQVQHVYQV | 
    1000:
    RIQPSAYDHN | MPTLEALVGV | PWPHSEDPIT | YTWSVQTDPL | VTCHSEDLKR | 
    1050:
    PSSEAEQPCL | PGVQFRCPIV | FRREILIQVT | GTVELSKEIK | ASSTLSLCSS | 
    1100:
    LSVSFNSSKH | FHLYGSKASE | AQVLVKVDLI | HEKEMLHVYV | LSGIGGLVLL | 
    1150:
    FLIFLALYKV | GFFKRNLKEK | MEADGGVPNG | SPPEDTDPLA | VPGEETKDMG | 
    1163:
    CLEPSGRVTR | TKA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Integrin alpha-L
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    E1572h
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    ELISA Kit for Mouse Integrin alpha-L
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    E1572b
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    ELISA Kit for Mouse Integrin alpha-L
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    E1572m
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    Packing:
    96T
    CLIA Kit for Mouse Integrin alpha-L
    Cat.:
    U1572m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Integrin alpha-L
    Cat.:
    U1572b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Integrin alpha-L
    Cat.:
    U1572h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Integrin alpha-L
    Polyclonal Antibody for Mouse Integrin alpha-L
    Cat.:
    P1572Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Integrin alpha-L
    Cat.:
    P1572Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Integrin alpha-L
    Monoclonal Antibody for Mouse Integrin alpha-L
    Monoclonal Antibody for Mouse Integrin alpha-L
    Protein for Mouse Integrin alpha-L
    Protein for Mouse Integrin alpha-L
    Protein for Mouse Integrin alpha-L

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning of the murine lymphocyte function-associated molecule-1 alpha-subunit and its expression in COS cells."
      Kaufmann Y. , Tseng E. , Springer T.A.
      J. Immunol.147:369-374(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon."
      Springer T.A. , Teplow D.B. , Dreyer W.J.
      Nature314:540-542(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-42
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