Gene name:
Itgal (Lfa-1;Ly-15) ;
Protein name:
Integrin alpha-L ;
Alternative:
Leukocyte adhesion glycoprotein LFA-1 alpha chain (LFA-1A) ;CD11 antigen-like family member A ;Lymphocyte antigen 15 (Ly-15) ;Leukocyte function-associated molecule 1 alpha chain ;
CD:
CD11a ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.
Function:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Mice expressing a null mutation of the alpha-L subunit gene demonstrate impaired tumor rejection and impaired leukocytes recruitment.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MSFRIAGPRL | LLLGLQLFAK | AWSYNLDTRP | TQSFLAQAGR | HFGYQVLQIE |
100:
DGVVVGAPGE | GDNTGGLYHC | RTSSEFCQPV | SLHGSNHTSK | YLGMTLATDA |
150:
AKGSLLACDP | GLSRTCDQNT | YLSGLCYLFP | QSLEGPMLQN | RPAYQECMKG |
200:
KVDLVFLFDG | SQSLDRKDFE | KILEFMKDVM | RKLSNTSYQF | AAVQFSTDCR |
250:
TEFTFLDYVK | QNKNPDVLLG | SVQPMFLLTN | TFRAINYVVA | HVFKEESGAR |
300:
PDATKVLVII | TDGEASDKGN | ISAAHDITRY | IIGIGKHFVS | VQKQKTLHIF |
350:
ASEPVEEFVK | ILDTFEKLKD | LFTDLQRRIY | AIEGTNRQDL | TSFNMELSSS |
400:
GISADLSKGH | AVVGAVGAKD | WAGGFLDLRE | DLQGATFVGQ | EPLTSDVRGG |
450:
YLGYTVAWMT | SRSSRPLLAA | GAPRYQHVGQ | VLLFQAPEAG | GRWNQTQKIE |
500:
GTQIGSYFGG | ELCSVDLDQD | GEAELLLIGA | PLFFGEQRGG | RVFTYQRRQS |
550:
LFEMVSELQG | DPGYPLGRFG | AAITALTDIN | GDRLTDVAVG | APLEEQGAVY |
600:
IFNGKPGGLS | PQPSQRIQGA | QVFPGIRWFG | RSIHGVKDLG | GDRLADVVVG |
650:
AEGRVVVLSS | RPVVDVVTEL | SFSPEEIPVH | EVECSYSARE | EQKHGVKLKA |
700:
CFRIKPLTPQ | FQGRLLANLS | YTLQLDGHRM | RSRGLFPDGS | HELSGNTSIT |
750:
PDKSCLDFHF | HFPICIQDLI | SPINVSLNFS | LLEEEGTPRD | QKGRAMQPIL |
800:
RPSIHTVTKE | IPFEKNCGED | KKCEANLTLS | SPARSGPLRL | MSSASLAVEW |
850:
TLSNSGEDAY | WVRLDLDFPR | GLSFRKVEML | QPHSRMPVSC | EELTEGSSLL |
900:
TKTLKCNVSS | PIFKAGQEVS | LQVMFNTLLN | SSWEDFVELN | GTVHCENENS |
950:
SLQEDNSAAT | HIPVLYPVNI | LTKEQENSTL | YISFTPKGPK | TQQVQHVYQV |
1000:
RIQPSAYDHN | MPTLEALVGV | PWPHSEDPIT | YTWSVQTDPL | VTCHSEDLKR |
1050:
PSSEAEQPCL | PGVQFRCPIV | FRREILIQVT | GTVELSKEIK | ASSTLSLCSS |
1100:
LSVSFNSSKH | FHLYGSKASE | AQVLVKVDLI | HEKEMLHVYV | LSGIGGLVLL |
1150:
FLIFLALYKV | GFFKRNLKEK | MEADGGVPNG | SPPEDTDPLA | VPGEETKDMG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
ELISA Kit for Mouse Integrin alpha-L
ELISA Kit for Mouse Integrin alpha-L
ELISA Kit for Mouse Integrin alpha-L
CLIA Kit for Mouse Integrin alpha-L
CLIA Kit for Mouse Integrin alpha-L
CLIA Kit for Mouse Integrin alpha-L
Polyclonal Antibody for Mouse Integrin alpha-L
Polyclonal Antibody for Mouse Integrin alpha-L
Polyclonal Antibody for Mouse Integrin alpha-L
Monoclonal Antibody for Mouse Integrin alpha-L
Monoclonal Antibody for Mouse Integrin alpha-L
Monoclonal Antibody for Mouse Integrin alpha-L
Protein for Mouse Integrin alpha-L
Protein for Mouse Integrin alpha-L
Protein for Mouse Integrin alpha-L
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
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Goodstadt L.
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Hillier L.W.
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Zody M.C.
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Goldstein S.
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She X.
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Meric P.
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Maglott D.
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Graves T.
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Zhou S.
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Teague B.
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Potamousis K.
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Churas C.
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Place M.
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Herschleb J.
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Runnheim R.
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Forrest D.
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more...
PLoS Biol.7:E1000112-E1000112(2009)
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 24-42