Protein name:
Integrin alpha-M ;
Alternative:
CR-3 alpha chain ;CD11 antigen-like family member B ;Leukocyte adhesion receptor MO1 ;Cell surface glycoprotein MAC-1 subunit alpha ;
CD:
CD11b ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer of an alpha and a beta chain. Alpha-M associates with beta-2. Interacts with JAM3.
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MTLKALLVTA | LALCHGFNLD | TEHPMTFQEN | AKGFGQNVVQ | LGGTSVVVAA |
100:
PQEAKAVNQT | GALYQCDYST | SRCHPIPLQV | PPEAVNMSLG | LSLAVSTVPQ |
150:
QLLACGPTVH | QNCKENTYVN | GLCYLFGSNL | LRPPQQFPEA | LRECPQQESD |
200:
IVFLIDGSGS | INNIDFQKMK | EFVSTVMEQF | KKSKTLFSLM | QYSDEFRIHF |
250:
TFNDFKRNPS | PRSHVSPIKQ | LNGRTKTASG | IRKVVRELFH | KTNGARENAA |
300:
KILVVITDGE | KFGDPLDYKD | VIPEADRAGV | IRYVIGVGNA | FNKPQSRREL |
350:
DTIASKPAGE | HVFQVDNFEA | LNTIQNQLQE | KIFAIEGTQT | GSTSSFEHEM |
400:
SQEGFSASIT | SNGPLLGSVG | SFDWAGGAFL | YTSKDKVTFI | NTTRVDSDMN |
450:
DAYLGYASAV | ILRNRVQSLV | LGAPRYQHIG | LVVMFRENFG | TWEPHTSIKG |
500:
SQIGSYFGAS | LCSVDMDADG | NTNLILIGAP | HYYEKTRGGQ | VSVCPLPRGR |
550:
ARWQCEALLH | GDQGHPWGRF | GAALTVLGDV | NGDKLTDVAI | GAPGEQENQG |
600:
AVYIFYGASI | ASLSASHSHR | IIGAHFSPGL | QYFGQSLSGG | KDLTMDGLMD |
650:
LAVGAQGHLL | LLRAQPVLRL | EATMEFSPKK | VARSVFACQE | QVLKNKDAGE |
700:
VRVCLRVRKN | TKDRLREGDI | QSTVTYDLAL | DPVRSRIRAF | FDETKNNTRR |
750:
RTQVFGLMQK | CETLKLILPD | CVDDSVSPII | LRLNYTLVGE | PLRSFGNLRP |
800:
VLAMDAQRFF | TAMFPFEKNC | GNDSICQDDL | SITMSAMGLD | TLVVGGPQDF |
850:
NMSVTLRNDG | EDSYGTQVTV | YYPSGLSYRK | DSASQNPLTK | KPWFVKPAES |
900:
SSSSEGHGAL | KSTTWNINHP | IFPANSEVTF | NVTFDVDSHA | SFGNKLLLKA |
950:
IVASENNMSR | THKTKFQLEL | PVKYAIYMIV | TSDESSIRYL | NFTASEMTSK |
1000:
VIQHQYQFNN | LGQRSLPVSV | VFWIPVQINN | VTVWDHPQVI | FSQNLSSACH |
1050:
TEQKSPPHSN | FRDQLERTPV | LNCSVAVCKR | IQCDLPSFNT | QEIFNVTLKG |
1100:
NLSFDWYIKT | SHGHLLLVSS | TEILFNDSAF | ALLPGQESYV | RSKTETKVEP |
1150:
YEVHNPVPLI | VGSSIGGLVL | LALITAGLYK | LGFFKRQYKD | MMNEAAPQDA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Integrin alpha-M
ELISA Kit for Mouse Integrin alpha-M
CLIA Kit for Mouse Integrin alpha-M
CLIA Kit for Mouse Integrin alpha-M
Polyclonal Antibody for Mouse Integrin alpha-M
Polyclonal Antibody for Mouse Integrin alpha-M
Monoclonal Antibody for Mouse Integrin alpha-M
Monoclonal Antibody for Mouse Integrin alpha-M
Protein for Mouse Integrin alpha-M
Protein for Mouse Integrin alpha-M
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
C57BL/6J .
tissue :
Spinal cord .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-45
strain :
BALB/c .
tissue :
Spleen .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 17-28