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Index > Protein center > Itgam(Gene name) > Mouse
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  • Itgam (Gene name),
  • Integrin alpha-M (Protein name ),  ITAM_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Itgam;
    Protein name:
    Integrin alpha-M;
    Alternative:
    CR-3 alpha chain;CD11 antigen-like family member B;Leukocyte adhesion receptor MO1;Cell surface glycoprotein MAC-1 subunit alpha;
    CD:
    CD11b;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta chain. Alpha-M associates with beta-2. Interacts with JAM3.
    Function:
    Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Alpha-M/beta-2 play a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the alpha-M subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1153
    Sequence:
    50:
    MTLKALLVTA | LALCHGFNLD | TEHPMTFQEN | AKGFGQNVVQ | LGGTSVVVAA | 
    100:
    PQEAKAVNQT | GALYQCDYST | SRCHPIPLQV | PPEAVNMSLG | LSLAVSTVPQ | 
    150:
    QLLACGPTVH | QNCKENTYVN | GLCYLFGSNL | LRPPQQFPEA | LRECPQQESD | 
    200:
    IVFLIDGSGS | INNIDFQKMK | EFVSTVMEQF | KKSKTLFSLM | QYSDEFRIHF | 
    250:
    TFNDFKRNPS | PRSHVSPIKQ | LNGRTKTASG | IRKVVRELFH | KTNGARENAA | 
    300:
    KILVVITDGE | KFGDPLDYKD | VIPEADRAGV | IRYVIGVGNA | FNKPQSRREL | 
    350:
    DTIASKPAGE | HVFQVDNFEA | LNTIQNQLQE | KIFAIEGTQT | GSTSSFEHEM | 
    400:
    SQEGFSASIT | SNGPLLGSVG | SFDWAGGAFL | YTSKDKVTFI | NTTRVDSDMN | 
    450:
    DAYLGYASAV | ILRNRVQSLV | LGAPRYQHIG | LVVMFRENFG | TWEPHTSIKG | 
    500:
    SQIGSYFGAS | LCSVDMDADG | NTNLILIGAP | HYYEKTRGGQ | VSVCPLPRGR | 
    550:
    ARWQCEALLH | GDQGHPWGRF | GAALTVLGDV | NGDKLTDVAI | GAPGEQENQG | 
    600:
    AVYIFYGASI | ASLSASHSHR | IIGAHFSPGL | QYFGQSLSGG | KDLTMDGLMD | 
    650:
    LAVGAQGHLL | LLRAQPVLRL | EATMEFSPKK | VARSVFACQE | QVLKNKDAGE | 
    700:
    VRVCLRVRKN | TKDRLREGDI | QSTVTYDLAL | DPVRSRIRAF | FDETKNNTRR | 
    750:
    RTQVFGLMQK | CETLKLILPD | CVDDSVSPII | LRLNYTLVGE | PLRSFGNLRP | 
    800:
    VLAMDAQRFF | TAMFPFEKNC | GNDSICQDDL | SITMSAMGLD | TLVVGGPQDF | 
    850:
    NMSVTLRNDG | EDSYGTQVTV | YYPSGLSYRK | DSASQNPLTK | KPWFVKPAES | 
    900:
    SSSSEGHGAL | KSTTWNINHP | IFPANSEVTF | NVTFDVDSHA | SFGNKLLLKA | 
    950:
    IVASENNMSR | THKTKFQLEL | PVKYAIYMIV | TSDESSIRYL | NFTASEMTSK | 
    1000:
    VIQHQYQFNN | LGQRSLPVSV | VFWIPVQINN | VTVWDHPQVI | FSQNLSSACH | 
    1050:
    TEQKSPPHSN | FRDQLERTPV | LNCSVAVCKR | IQCDLPSFNT | QEIFNVTLKG | 
    1100:
    NLSFDWYIKT | SHGHLLLVSS | TEILFNDSAF | ALLPGQESYV | RSKTETKVEP | 
    1150:
    YEVHNPVPLI | VGSSIGGLVL | LALITAGLYK | LGFFKRQYKD | MMNEAAPQDA | 
    1153:
    PPQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Integrin alpha-M
    Cat.:
    E1685m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Integrin alpha-M
    Cat.:
    E1685h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse Integrin alpha-M
    Cat.:
    U1685h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Integrin alpha-M
    Cat.:
    U1685m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Integrin alpha-M
    Cat.:
    P1685Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Integrin alpha-M
    Cat.:
    P1685Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Integrin alpha-M
    Cat.:
    M1685h
    Price:
    Please sign in first.
    Packing:
    40ug
    Monoclonal Antibody for Mouse Integrin alpha-M
    Protein for Mouse Integrin alpha-M
    Protein for Mouse Integrin alpha-M

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor."
      Pytela R.
      EMBO J.7:1371-1378(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Spinal cord.
    3. 3.
      "A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1."
      Sastre L. , Roman J.M. , Teplow D.B. , Dreyer W.J. , Gee C.E. , Larson R.S. , Roberts T.M. , Springer T.A.
      Proc. Natl. Acad. Sci. U.S.A.83:5644-5648(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-45
      strain: BALB/c.
      tissue: Spleen.
    4. 4.
      "Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion glycoproteins and unexpected relation to leukocyte interferon."
      Springer T.A. , Teplow D.B. , Dreyer W.J.
      Nature314:540-542(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-28
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