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Index > Protein center > ITGAX(Gene name) > Human
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  • ITGAX (Gene name),
  • Integrin alpha-X (Protein name ),  ITAX_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ITGAX(CD11C);
    Protein name:
    Integrin alpha-X;
    Alternative:
    Leu M5;CD11 antigen-like family member C;Leukocyte adhesion receptor p150,95;Leukocyte adhesion glycoprotein p150,95 alpha chain;
    CD:
    CD11c;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.
    Function:
    Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1163
    Sequence:
    50:
    MTRTRAALLL | FTALATSLGF | NLDTEELTAF | RVDSAGFGDS | VVQYANSWVV | 
    100:
    VGAPQKITAA | NQTGGLYQCG | YSTGACEPIG | LQVPPEAVNM | SLGLSLASTT | 
    150:
    SPSQLLACGP | TVHHECGRNM | YLTGLCFLLG | PTQLTQRLPV | SRQECPRQEQ | 
    200:
    DIVFLIDGSG | SISSRNFATM | MNFVRAVISQ | FQRPSTQFSL | MQFSNKFQTH | 
    250:
    FTFEEFRRSS | NPLSLLASVH | QLQGFTYTAT | AIQNVVHRLF | HASYGARRDA | 
    300:
    AKILIVITDG | KKEGDSLDYK | DVIPMADAAG | IIRYAIGVGL | AFQNRNSWKE | 
    350:
    LNDIASKPSQ | EHIFKVEDFD | ALKDIQNQLK | EKIFAIEGTE | TTSSSSFELE | 
    400:
    MAQEGFSAVF | TPDGPVLGAV | GSFTWSGGAF | LYPPNMSPTF | INMSQENVDM | 
    450:
    RDSYLGYSTE | LALWKGVQSL | VLGAPRYQHT | GKAVIFTQVS | RQWRMKAEVT | 
    500:
    GTQIGSYFGA | SLCSVDVDSD | GSTDLVLIGA | PHYYEQTRGG | QVSVCPLPRG | 
    550:
    WRRWWCDAVL | YGEQGHPWGR | FGAALTVLGD | VNGDKLTDVV | IGAPGEEENR | 
    600:
    GAVYLFHGVL | GPSISPSHSQ | RIAGSQLSSR | LQYFGQALSG | GQDLTQDGLV | 
    650:
    DLAVGARGQV | LLLRTRPVLW | VGVSMQFIPA | EIPRSAFECR | EQVVSEQTLV | 
    700:
    QSNICLYIDK | RSKNLLGSRD | LQSSVTLDLA | LDPGRLSPRA | TFQETKNRSL | 
    750:
    SRVRVLGLKA | HCENFNLLLP | SCVEDSVTPI | TLRLNFTLVG | KPLLAFRNLR | 
    800:
    PMLAADAQRY | FTASLPFEKN | CGADHICQDN | LGISFSFPGL | KSLLVGSNLE | 
    850:
    LNAEVMVWND | GEDSYGTTIT | FSHPAGLSYR | YVAEGQKQGQ | LRSLHLTCDS | 
    900:
    APVGSQGTWS | TSCRINHLIF | RGGAQITFLA | TFDVSPKAVL | GDRLLLTANV | 
    950:
    SSENNTPRTS | KTTFQLELPV | KYAVYTVVSS | HEQFTKYLNF | SESEEKESHV | 
    1000:
    AMHRYQVNNL | GQRDLPVSIN | FWVPVELNQE | AVWMDVEVSH | PQNPSLRCSS | 
    1050:
    EKIAPPASDF | LAHIQKNPVL | DCSIAGCLRF | RCDVPSFSVQ | EELDFTLKGN | 
    1100:
    LSFGWVRQIL | QKKVSVVSVA | EITFDTSVYS | QLPGQEAFMR | AQTTTVLEKY | 
    1150:
    KVHNPTPLIV | GSSIGGLLLL | ALITAVLYKV | GFFKRQYKEM | MEEANGQIAP | 
    1163:
    ENGTQTPSPP | SEK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Integrin alpha-X
    Cat.:
    E9095h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Integrin alpha-X
    Cat.:
    E9095m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Integrin alpha-X
    Cat.:
    U9095m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Integrin alpha-X
    Cat.:
    U9095h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Integrin alpha-X
    Cat.:
    P9095Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Integrin alpha-X
    Cat.:
    P9095Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Integrin alpha-X
    Monoclonal Antibody for Human Integrin alpha-X
    Protein for Human Integrin alpha-X
    Protein for Human Integrin alpha-X

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95."
      Corbi A.L. , Miller L.J. , O'Connor K. , Larson R.S. , Springer T.A.
      EMBO J.6:4023-4028(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-251
    2. 2.
      "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule."
      Corbi A.L. , Garcia-Aguilar J. , Springer T.A.
      J. Biol. Chem.265:2782-2788(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-201 AND THR-251
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-547
      tissue: Blood.
    5. 5.
      "Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins."
      Miller L.J. , Wiebe M. , Springer T.A.
      J. Immunol.138:2381-2383(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-43
    6. 6.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-899
      tissue: Liver.
    7. 7.
      "Structure of an integrin with an alphaI domain, complement receptor type 4."
      Xie C. , Zhu J. , Chen X. , Mi L. , Nishida N. , Springer T.A.
      EMBO J.29:666-679(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 20-1103 IN COMPLEX WITH ITGB2;GLYCOSYLATION AT ASN-61; ASN-392; ASN-697; ASN-735 AND ASN-899;DISULFIDE BONDS;METAL-BINDING SITES;SUBUNIT
    8. 8.
      "Structure and binding interface of the cytosolic tails of alphaXbeta2 integrin."
      Chua G.L. , Tang X.Y. , Patra A.T. , Tan S.M. , Bhattacharjya S.
      PLoS ONE7:E41924-E41924(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1129-1163
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