ITGB7 ELISA Kit for Human(Homo sapiens) | EIAab.comITGB7 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ITGB7(Gene name) > Human

ITGB7 (Gene name),

Integrin beta-7 (Protein name ), ITB7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ITGB7;

Protein name:

Integrin beta-7;

Alternative:

Gut homing receptor beta subunit;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120.

Function:

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

798

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

798:

EIYDRREYSR | FEKEQQQLNW | KQDSNPLYKS | AITTTINPRF | QEADSPTL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.654470

SMR:

P26010

Pfam:

PF07974

String:

P26010

Pfam:

PF08725

KEGG:

hsa:3695

MIM:

147559

STRING:

9606.ENSP00000267082

Uniprot:

P26010

FOR

ELISA Kit for Human Integrin beta-7

CLIA Kit for Human Integrin beta-7

Polyclonal Antibody for Human Integrin beta-7

Monoclonal Antibody for Human Integrin beta-7

Protein for Human Integrin beta-7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains."
Yuan Q. , Jiang W.-M. , Krissansen G.W. , Watson J.D.
Int. Immunol.2:1097-1108(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
tissue: T-cell.
2.

"Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains."
Yuan Q. , Jiang W.-M. , Krissansen G.W. , Watson J.D.
Int. Immunol.3:1373-1374(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes."
Erle D.J. , Rueegg C. , Sheppard D. , Pytela R.
J. Biol. Chem.266:11009-11016(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
tissue: Leukocyte.
4.

"The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1."
Jiang W.-M. , Jenkins D. , Yuan Q. , Leung E. , Choo K.H. , Watson J.D. , Krissansen G.W.
Int. Immunol.4:1031-1040(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue: Colon.
6.

"A family of beta 7 integrins on human mucosal lymphocytes."
Parker C.M. , Cepek K.L. , Russell G.J. , Shaw S.K. , Posnett D.N. , Schwarting R. , Brenner M.B.
Proc. Natl. Acad. Sci. U.S.A.89:1924-1928(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-36;INTERACTION WITH INTEGRIN ALPHA-4 AND INTEGRIN ALPHA-E;INDUCTION
7.

"HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit."
Micklem K.J. , Dong Y. , Willis A. , Pulford K.A. , Visser L. , Duerkop H. , Poppema S. , Stein H. , Mason D.Y.
Am. J. Pathol.139:1297-1301(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-34
tissue: Leukemia.
8.

"The role of alpha and beta chains in ligand recognition by beta 7 integrins."
Higgins J.M.G. , Cernadas M. , Tan K. , Irie A. , Wang J.-H. , Takada Y. , Brenner M.B.
J. Biol. Chem.275:25652-25664(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-159
9.

"Integrins: bidirectional, allosteric signaling machines."
Hynes R.O.
Cell110:673-687(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
10.

"HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells."
Arthos J. , Cicala C. , Martinelli E. , Macleod K. , Van Ryk D. , Wei D. , Xiao Z. , Veenstra T.D. , Conrad T.P. , Lempicki R.A. , McLaughlin S. , Pascuccio M. , Gopaul R. , McNally J. , Cruz C.C. , Censoplano N. , Chung E. , Reitano K.N. , more...
Nat. Immunol.9:301-309(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 GP120
11.

"The molecular basis of filamin binding to integrins and competition with talin."
Kiema T. , Lad Y. , Jiang P. , Oxley C.L. , Baldassarre M. , Wegener K.L. , Campbell I.D. , Ylanne J. , Calderwood D.A.
Mol. Cell21:337-347(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 768-798

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