TCF4 ELISA Kit for Human(Homo sapiens) | EIAab.comTCF4 ELISA Kit for Human(Homo sapiens)

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TCF4 (Gene name),

Transcription factor 4 (Protein name ), ITF2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TCF4(BHLHB19;ITF2;SEF2);

Protein name:

Transcription factor 4(TCF-4);

Alternative:

Immunoglobulin transcription factor 2(ITF-2);Class B basic helix-loop-helix protein 19(bHLHb19);SL3-3 enhancer factor 2(SEF-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin. Interacts with HIVEP2. Interacts with NEUROD2.

Function:

Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

667

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

667:

AGPHPGMGDA | SNHMGQM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P15884

MIM:

602272

KEGG:

hsa:6925

UniGene:

Hs.605153

STRING:

9606.ENSP00000346440

SMR:

P15884

Pfam:

PF00010

Uniprot:

P15884

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ELISA Kit for Human TCF-4

Cat.:

E1408h

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96T

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ELISA Kit for Human TCF-4

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ELISA Kit for Human TCF-4

Cat.:

E1408d

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96T

ELISA Kit for Human TCF-4

Cat.:

E1408m

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96T

ELISA Kit for Human TCF-4

Cat.:

E1408r

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96T

CLIA Kit for Human TCF-4

Cat.:

U1408h

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96T

CLIA Kit for Human TCF-4

Cat.:

U1408r

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96T

CLIA Kit for Human TCF-4

Cat.:

U1408d

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MSDS:

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Packing:

96T

CLIA Kit for Human TCF-4

Cat.:

U1408m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human TCF-4

MSDS:

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Polyclonal Antibody for Human TCF-4

Cat.:

P1408Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TCF-4

Cat.:

P1408Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human TCF-4

Cat.:

P1408Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human TCF-4

Protein for Human TCF-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers."
Corneliussen B. , Thornell A. , Hallberg B. , Grundstroem T.
J. Virol.65:6084-6093(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SEF2-1A; SEF2-1B AND SEF2-1D);ALTERNATIVE SPLICING (ISOFORM SEF2-1C)
tissue: Thymocyte.
tissue: Thymus.
2.

"Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing."
Sepp M. , Kannike K. , Eesmaa A. , Urb M. , Timmusk T.
PLoS ONE6:E22138-E22138(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A-; B-DELTA; B+DELTA; C-; C-DELTA; D-; E-; F-; G-; H-; I-; SEF2-1A; SEF2-1B AND SEF2-1D);ALTERNATIVE SPLICING
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SEF2-1A; C-; D-; F-; 11 AND 13)
tissue: Brain.
tissue: Hippocampus.
tissue: Spleen.
tissue: Teratocarcinoma.
4.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SEF2-1B AND SEF2-1D)
7.

"MDSDCE06_MDS Homo sapiens cDNA clone MDSDCE06 5',mRNA sequence."
Gu J. , Zhao M. , Huang Q. , Xu X. , Li Y. , Peng Y. , Song H. , Xiao H. , Gu Y. , Li N. , Qian B. , Liu F. , Qu J. , Gao X. , Cheng Z. , Xu Z. , Zeng L. , Xu S. , more...
Submitted (2000-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-278 (ISOFORM SEF2-1A)
8.

"A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1."
Breschel T.S. , McInnis M.G. , Margolis R.L. , Sirugo G. , Corneliussen B. , Simpson S.G. , McMahon F.J. , Mackinnon D.F. , Xu J.F. , Pleasant N. , Huo Y. , Ashworth R.G. , Grundstrom C. , Grundstrom T. , Kidd K.K. , Depaulo J.R. , Ross C.A.
Hum. Mol. Genet.6:1855-1863(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-48
tissue: Skin fibroblast.
9.

"Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor."
Henthorn P. , McCarrick-Walmsley R. , Kadesch T.
Nucleic Acids Res.18:678-678(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-667 (ISOFORM SEF2-1B)
10.

"Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif."
Henthorn P. , Kiledjian M. , Kadesch T.
Science247:467-470(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISCUSSION OF SEQUENCE
11.

"Nine-amino-acid transactivation domain: establishment and prediction utilities."
Piskacek S. , Gregor M. , Nemethova M. , Grabner M. , Kovarik P. , Piskacek M.
Genomics89:756-768(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
12.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-515;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome."
Forrest M. , Chapman R.M. , Doyle A.M. , Tinsley C.L. , Waite A. , Blake D.J.
Hum. Mutat.33:1676-1686(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANTS PTHS VAL-358; GLY-535; PRO-574; TRP-576 AND VAL-610
14.

"Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4."
Riazuddin S.A. , Vasanth S. , Katsanis N. , Gottsch J.D.
Am. J. Hum. Genet.93:758-764(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGBL1
15.

"Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction."
Amiel J. , Rio M. , de Pontual L. , Redon R. , Malan V. , Boddaert N. , Plouin P. , Carter N.P. , Lyonnet S. , Munnich A. , Colleaux L.
Am. J. Hum. Genet.80:988-993(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PTHS TRP-576 AND GLN-576
16.

"Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome)."
Zweier C. , Peippo M.M. , Hoyer J. , Sousa S. , Bottani A. , Clayton-Smith J. , Reardon W. , Saraiva J. , Cabral A. , Goehring I. , Devriendt K. , de Ravel T. , Bijlsma E.K. , Hennekam R.C.M. , Orrico A. , Cohen M. , Dreweke A. , Reis A. , more...
Am. J. Hum. Genet.80:994-1001(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PTHS TRP-576
17.

"Further delineation of Pitt-Hopkins syndrome: phenotypic and genotypic description of 16 novel patients."
Zweier C. , Sticht H. , Bijlsma E.K. , Clayton-Smith J. , Boonen S.E. , Fryer A. , Greally M.T. , Hoffmann L. , den Hollander N.S. , Jongmans M. , Kant S.G. , King M.D. , Lynch S.A. , McKee S. , Midro A.T. , Park S.M. , Ricotti V. , Tarantino E. , more...
J. Med. Genet.45:738-744(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PTHS VAL-358; PRO-574 AND HIS-578
18.

"Mutational, functional, and expression studies of the TCF4 gene in Pitt-Hopkins syndrome."
de Pontual L. , Mathieu Y. , Golzio C. , Rio M. , Malan V. , Boddaert N. , Soufflet C. , Picard C. , Durandy A. , Dobbie A. , Heron D. , Isidor B. , Motte J. , Newburry-Ecob R. , Pasquier L. , Tardieu M. , Viot G. , Jaubert F. , more...
Hum. Mutat.30:669-676(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PTHS GLY-535; GLY-572; GLN-576 AND VAL-610;CHARACTERIZATION OF VARIANTS PTHS GLY-535; GLY-572; GLN-576 AND VAL-610
19.

"Two percent of patients suspected of having Angelman syndrome have TCF4 mutations."
Takano K. , Lyons M. , Moyes C. , Jones J. , Schwartz C.E.
Clin. Genet.78:282-288(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PTHS PRO-578
20.

"Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum."
Whalen S. , Heron D. , Gaillon T. , Moldovan O. , Rossi M. , Devillard F. , Giuliano F. , Soares G. , Mathieu-Dramard M. , Afenjar A. , Charles P. , Mignot C. , Burglen L. , Van Maldergem L. , Piard J. , Aftimos S. , Mancini G. , Dias P. , more...
Hum. Mutat.33:64-72(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PTHS TRP-565; GLY-572; GLN-572; HIS-574; PRO-574; TRP-576; GLN-576; PRO-578; PRO-583 AND VAL-610

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