ITIH2 ELISA Kit for Human(Homo sapiens) | EIAab.comITIH2 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ITIH2 (Gene name),

Inter-alpha-trypsin inhibitor heavy chain H2 (Protein name ), ITIH2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

ITIH2(IGHEP2);

Protein name:

Inter-alpha-trypsin inhibitor heavy chain H2(ITI heavy chain H2;ITI-HC2;Inter-alpha-inhibitor heavy chain 2);

Alternative:

Serum-derived hyaluronan-associated protein(SHAP);Inter-alpha-trypsin inhibitor complex component II;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Function:

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

946

Sequence:

50:

MKRLTCFFIC | FFLSEVSGFE | IPINGLSEFV | DYEDLVELAP | GKFQLVAENR |

100:

RYQRSLPGES | EEMMEEVDQV | TLYSYKVQST | ITSRMATTMI | QSKVVNNSPQ |

150:

PQNVVFDVQI | PKGAFISNFS | MTVDGKTFRS | SIKEKTVGRA | LYAQARAKGK |

200:

TAGLVRSSAL | DMENFRTEVN | VLPGAKVQFE | LHYQEVKWRK | LGSYEHRIYL |

250:

QPGRLAKHLE | VDVWVIEPQG | LRFLHVPDTF | EGHFDGVPVI | SKGQQKAHVS |

300:

FKPTVAQQRI | CPNCRETAVD | GELVVLYDVK | REEKAGELEV | FNGYFVHFFA |

350:

PDNLDPIPKN | ILFVIDVSGS | MWGVKMKQTV | EAMKTILDDL | RAEDHFSVID |

400:

FNQNIRTWRN | DLISATKTQV | ADAKRYIEKI | QPSGGTNINE | ALLRAIFILN |

450:

EANNLGLLDP | NSVSLIILVS | DGDPTVGELK | LSKIQKNVKE | NIQDNISLFS |

500:

LGMGFDVDYD | FLKRLSNENH | GIAQRIYGNQ | DTSSQLKKFY | NQVSTPLLRN |

550:

VQFNYPHTSV | TDVTQNNFHN | YFGGSEIVVA | GKFDPAKLDQ | IESVITATSA |

600:

NTQLVLETLA | QMDDLQDFLS | KDKHADPDFT | RKLWAYLTIN | QLLAERSLAP |

650:

TAAAKRRITR | SILQMSLDHH | IVTPLTSLVI | ENEAGDERML | ADAPPQDPSC |

700:

CSGALYYGSK | VVPDSTPSWA | NPSPTPVISM | LAQGSQVLES | TPPPHVMRVE |

750:

NDPHFIIYLP | KSQKNICFNI | DSEPGKILNL | VSDPESGIVV | NGQLVGAKKP |

800:

NNGKLSTYFG | KLGFYFQSED | IKIEISTETI | TLSHGSSTFS | LSWSDTAQVT |

850:

NQRVQISVKK | EKVVTITLDK | EMSFSVLLHR | VWKKHPVNVD | FLGIYIPPTN |

900:

KFSPKAHGLI | GQFMQEPKIH | IFNERPGKDP | EKPEASMEVK | GQKLIITRGL |

946:

QKDYRTDLVF | GTDVTCWFVH | NSGKGFIDGH | YKDYFVPQLY | SFLKRP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Pfam:

STRING:

9606.ENSP00000351190

MIM:

UniGene:

SMR:

KEGG:

Uniprot:

FOR

ELISA Kit for Human ITI heavy chain H2

ELISA Kit for Human ITI heavy chain H2

ELISA Kit for Human ITI heavy chain H2

ELISA Kit for Human ITI heavy chain H2

CLIA Kit for Human ITI heavy chain H2

CLIA Kit for Human ITI heavy chain H2

CLIA Kit for Human ITI heavy chain H2

CLIA Kit for Human ITI heavy chain H2

Polyclonal Antibody for Human ITI heavy chain H2

Polyclonal Antibody for Human ITI heavy chain H2

Polyclonal Antibody for Human ITI heavy chain H2

Polyclonal Antibody for Human ITI heavy chain H2

Monoclonal Antibody for Human ITI heavy chain H2

Monoclonal Antibody for Human ITI heavy chain H2

Monoclonal Antibody for Human ITI heavy chain H2

Monoclonal Antibody for Human ITI heavy chain H2

Protein for Human ITI heavy chain H2

Protein for Human ITI heavy chain H2

Protein for Human ITI heavy chain H2

Protein for Human ITI heavy chain H2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Complementary DNA and derived amino acid sequence of the precursor of one of the three protein components of the inter-alpha-trypsin inhibitor complex."
Gebhard W. , Schreitmueller T. , Hochstrasser K. , Wachter E.
FEBS Lett.229:63-67(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;GAMMA-CARBOXYGLUTAMATION AT GLU-282 AND GLU-283;VARIANT SER-263
2.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI."
Salier J.-P. , Diarra-Mehrpour M. , Sesboue R. , Bourguignon J. , Benarous R. , Ohkubo I. , Kurachi S. , Kurachi K. , Martin J.-P.
Proc. Natl. Acad. Sci. U.S.A.84:8272-8276(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 384-865
4.

"Human inter-alpha-trypsin inhibitor. Isolation and characterization of heavy (H) chain cDNA clones coding for a 383 amino-acid sequence of the H chain."
Salier J.-P. , Diarra-Mehrpour M. , Sesboue R. , Bourguignon J. , Martin J.-P.
Biol. Chem. Hoppe-Seyler369:15-18(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 384-766;VARIANT ALA-674
5.

"cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins."
Schreitmueller T. , Hochstrasser K. , Resinger P.W.M. , Wachter E. , Gebhard W.
Biol. Chem. Hoppe-Seyler368:963-970(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
6.

"Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan."
Enghild J.J. , Thoegersen I.B. , Pizzo S.V. , Salvesen G.
J. Biol. Chem.264:15975-15981(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 55-74; 116-127; 224-246; 295-307 AND 365-385
7.

"The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A."
Malki N. , Balduyck M. , Maes P. , Capon C. , Mizon C. , Han K.K. , Tartar A. , Fournet B. , Mizon J.
Biol. Chem. Hoppe-Seyler373:1009-1018(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 55-64
tissue: Plasma.
8.

"Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin."
Enghild J.J. , Salvesen G. , Thoegersen I.B. , Valnickova Z. , Pizzo S.V. , Hefta S.A.
J. Biol. Chem.268:8711-8716(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 55-64 AND 681-702;CROSS-LINK STRUCTURE;GLYCOSYLATION AT THR-691
9.

"TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor."
Wisniewski H.-G. , Burgess W.H. , Oppenheim J.D. , Vilcek J.
Biochemistry33:7423-7429(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 55-64;INTERACTION WITH TNFAIP6
10.

"A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor."
Huang L. , Yoneda M. , Kimata K.
J. Biol. Chem.268:26725-26730(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 67-101;HYALURONAN BINDING
tissue: Serum.
11.

"Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor."
Morelle W. , Capon C. , Balduyck M. , Sautiere P. , Kouach M. , Michalski C. , Fournet B. , Mizon J.
Eur. J. Biochem.221:881-888(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 699-702;COVALENT LINKAGE WITH CHONDROITIN SULFATE
tissue: Plasma.
12.

"Glycosylation pattern of human inter-alpha-inhibitor heavy chains."
Flahaut C. , Capon C. , Balduyck M. , Ricart G. , Sautiere P. , Mizon J.
Biochem. J.333:749-756(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-118; THR-666; SER-673; THR-675 AND THR-691;MASS SPECTROMETRY
13.

"Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2."
Olsen E.H.N. , Rahbek-Nielsen H. , Thoegersen I.B. , Roepstorff P. , Enghild J.J.
Biochemistry37:408-416(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-118; THR-666; SER-673; THR-675 AND THR-691;DISULFIDE BONDS
14.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-118
15.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-96; ASN-118 AND ASN-445
tissue: Plasma.
16.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118
tissue: Liver.
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY

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