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Index > Protein center > ITIH4(Gene name) > Human
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  • ITIH4 (Gene name),
  • Inter-alpha-trypsin inhibitor heavy chain H4 (Protein name ),  ITIH4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    ITIH4(PRO1851;IHRP;ITIHL1;PK120);
    Protein name:
    Inter-alpha-trypsin inhibitor heavy chain H4(ITI heavy chain H4;ITI-HC4;Inter-alpha-inhibitor heavy chain 4);
    Alternative:
    Plasma kallikrein sensitive glycoprotein 120(Gp120;PK-120);Inter-alpha-trypsin inhibitor family heavy chain-related protein(IHRP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May be involved in acute phase reactions.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    930
    Sequence:
    50:
    MKPPRPVRTC | SKVLVLLSLL | AIHQTTTAEK | NGIDIYSLTV | DSRVSSRFAH | 
    100:
    TVVTSRVVNR | ANTVQEATFQ | MELPKKAFIT | NFSMIIDGMT | YPGIIKEKAE | 
    150:
    AQAQYSAAVA | KGKSAGLVKA | TGRNMEQFQV | SVSVAPNAKI | TFELVYEELL | 
    200:
    KRRLGVYELL | LKVRPQQLVK | HLQMDIHIFE | PQGISFLETE | STFMTNQLVD | 
    250:
    ALTTWQNKTK | AHIRFKPTLS | QQQKSPEQQE | TVLDGNLIIR | YDVDRAISGG | 
    300:
    SIQIENGYFV | HYFAPEGLTT | MPKNVVFVID | KSGSMSGRKI | QQTREALIKI | 
    350:
    LDDLSPRDQF | NLIVFSTEAT | QWRPSLVPAS | AENVNKARSF | AAGIQALGGT | 
    400:
    NINDAMLMAV | QLLDSSNQEE | RLPEGSVSLI | ILLTDGDPTV | GETNPRSIQN | 
    450:
    NVREAVSGRY | SLFCLGFGFD | VSYAFLEKLA | LDNGGLARRI | HEDSDSALQL | 
    500:
    QDFYQEVANP | LLTAVTFEYP | SNAVEEVTQN | NFRLLFKGSE | MVVAGKLQDR | 
    550:
    GPDVLTATVS | GKLPTQNITF | QTESSVAEQE | AEFQSPKYIF | HNFMERLWAY | 
    600:
    LTIQQLLEQT | VSASDADQQA | LRNQALNLSL | AYSFVTPLTS | MVVTKPDDQE | 
    650:
    QSQVAEKPME | GESRNRNVHS | GSTFFKYYLQ | GAKIPKPEAS | FSPRRGWNRQ | 
    700:
    AGAAGSRMNF | RPGVLSSRQL | GLPGPPDVPD | HAAYHPFRRL | AILPASAPPA | 
    750:
    TSNPDPAVSR | VMNMKIEETT | MTTQTPAPIQ | APSAILPLPG | QSVERLCVDP | 
    800:
    RHRQGPVNLL | SDPEQGVEVT | GQYEREKAGF | SWIEVTFKNP | LVWVHASPEH | 
    850:
    VVVTRNRRSS | AYKWKETLFS | VMPGLKMTMD | KTGLLLLSDP | DKVTIGLLFW | 
    900:
    DGRGEGLRLL | LRDTDRFSSH | VGGTLGQFYQ | EVLWGSPAAS | DDGRRTLRVQ | 
    930:
    GNDHSATRER | RLDYQEGPPG | VEISCWSVEL | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    String:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human ITI heavy chain H4
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    ELISA Kit for Human ITI heavy chain H4
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    ELISA Kit for Human ITI heavy chain H4
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    ELISA Kit for Human ITI heavy chain H4
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    CLIA Kit for Human ITI heavy chain H4
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    CLIA Kit for Human ITI heavy chain H4
    Cat.:
    U13558h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human ITI heavy chain H4
    MSDS:
    Please sign in first.
    CLIA Kit for Human ITI heavy chain H4
    Cat.:
    U13558m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ITI heavy chain H4
    Polyclonal Antibody for Human ITI heavy chain H4
    Polyclonal Antibody for Human ITI heavy chain H4
    Polyclonal Antibody for Human ITI heavy chain H4
    Monoclonal Antibody for Human ITI heavy chain H4
    Monoclonal Antibody for Human ITI heavy chain H4
    Monoclonal Antibody for Human ITI heavy chain H4
    Monoclonal Antibody for Human ITI heavy chain H4
    Protein for Human ITI heavy chain H4
    Protein for Human ITI heavy chain H4
    Protein for Human ITI heavy chain H4
    Protein for Human ITI heavy chain H4

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    References
    1. 1.
      "cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein."
      Nishimura H. , Kakizaki I. , Muta T. , Sasaki N. , Pu P.X. , Yamashita T. , Nagasawa S.
      FEBS Lett.357:207-211(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      "Cloning and characterization of cDNA for inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP), a novel human plasma glycoprotein."
      Saguchi K. , Tobe T. , Hashimoto K. , Sano Y. , Nakano Y. , Miura N.-H. , Tomita M.
      J. Biochem.117:14-18(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;IDENTIFICATION;TISSUE SPECIFICITY;VARIANT ASN-85
      tissue: Liver.
    3. 3.
      "Isolation and characterization of the human inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene (ITIHL1)."
      Saguchi K. , Tobe T. , Hashimoto K. , Nagasaki Y. , Oda E. , Nakano Y. , Miura N.H. , Tomita M.
      J. Biochem.119:898-905(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Liver.
    5. 5.
      "BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4."
      Kroczynska B. , King-Simmons L. , Alloza L. , Alava M.A. , Elguindi E.C. , Blond S.Y.
      Biochem. Biophys. Res. Commun.338:1467-1477(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);INTERACTION WITH DNAJC1
    6. 6.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C. , Yu Y. , Zhang S. , Wei H. , Zhang Y. , Zhou G. , Bi J. , Liu M. , He F.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 271-930 (ISOFORM 2)
      tissue: Fetal liver.
    8. 8.
      "Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma."
      Choi-Miura N.-H. , Sano Y. , Oda E. , Nakano Y. , Tobe T. , Yanagishita T. , Taniyama M. , Katagiri T. , Tomita M.
      J. Biochem.117:400-407(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-44; 99-119; 140-151; 163-170; 194-208; 211-243; 274-281; 290-329; 429-487; 497-567; 608-626 AND 816-831;PROTEOLYTIC PROCESSING;GLYCOSYLATION
      tissue: Plasma.
    9. 9.
      "Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma."
      Pu X.P. , Iwamoto A. , Nishimura H. , Nagasawa S.
      Biochim. Biophys. Acta1208:338-343(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PROTEOLYTIC PROCESSING
    10. 10.
      "ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells."
      Pineiro M. , Alava M.A. , Gonzalez-Ramon N. , Osada J. , Lasierra P. , Larrad L. , Pineiro A. , Lampreave F.
      Biochem. Biophys. Res. Commun.263:224-229(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;INDUCTION
    11. 11.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-207
    12. 12.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-517
      tissue: Plasma.
    13. 13.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-207; ASN-517 AND ASN-577
      tissue: Plasma.
    14. 14.
      "Inter-alpha-trypsin inhibitor heavy chain 4 is a novel marker of acute ischemic stroke."
      Kashyap R.S. , Nayak A.R. , Deshpande P.S. , Kabra D. , Purohit H.J. , Taori G.M. , Daginawala H.F.
      Clin. Chim. Acta402:160-163(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    15. 15.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-81; ASN-207 AND ASN-517
      tissue: Liver.
    16. 16.
      "The absolute quantification of eight inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4)-derived peptides in serum from breast cancer patients."
      van den Broek I. , Sparidans R.W. , van Winden A.W. , Gast M.C. , van Dulken E.J. , Schellens J.H. , Beijnen J.H.
      Proteomics Clin. Appl.4:931-939(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ROLE OF ACTIVE PEPTIDE AS A BIOMARKER FOR BREAST CANCER
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
      Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
      Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-720;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
    19. 19.
      "SNP analysis of the inter-alpha-trypsin inhibitor family heavy chain-related protein (IHRP) gene by a fluorescence-adapted SSCP method."
      Tozaki T. , Choi-Miura N.-H. , Taniyama M. , Kurosawa M. , Tomita M.
      BMC Med. Genet.3:6-6(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-86
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