ITPA ELISA Kit for Human(Homo sapiens) | EIAab.comITPA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ITPA(Gene name) > Human

ITPA (Gene name),

Inosine triphosphate pyrophosphatase (Protein name ), ITPA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ITPA(My049;OK/SW-cl.9;C20orf37);

Protein name:

Inosine triphosphate pyrophosphatase(ITPase;Inosine triphosphatase);

Alternative:

Non-standard purine NTP pyrophosphatase;Non-canonical purine NTP pyrophosphatase;Nucleoside-triphosphate pyrophosphatase(NTPase);Nucleoside-triphosphate diphosphatase;Putative oncogene protein hlc14-06-p;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

194

Sequence:

50:

100:

150:

194:

WDPCFQPDGY | EQTYAEMPKA | EKNAVSHRFR | ALLELQEYFG | SLAA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3704

Pfam:

PF01725

String:

Q9BY32

MIM:

147520

SMR:

Q9BY32

STRING:

9606.ENSP00000369456

UniGene:

Hs.415299

Uniprot:

Q9BY32

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ELISA Kit for Human ITPase

Cat.:

E1446h

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Manual:

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96T

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ELISA Kit for Human ITPase

Cat.:

E1446c

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96T

ELISA Kit for Human ITPase

Cat.:

E1446b

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96T

ELISA Kit for Human ITPase

Cat.:

E1446r

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96T

ELISA Kit for Human ITPase

Cat.:

E1446m

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96T

CLIA Kit for Human ITPase

Cat.:

U1446r

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96T

CLIA Kit for Human ITPase

Cat.:

U1446c

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96T

CLIA Kit for Human ITPase

Cat.:

U1446h

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96T

CLIA Kit for Human ITPase

Cat.:

U1446b

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96T

CLIA Kit for Human ITPase

Cat.:

U1446m

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96T

Polyclonal Antibody for Human ITPase

Cat.:

P1446Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human ITPase

Cat.:

P1446Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human ITPase

Cat.:

P1446Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human ITPase

Protein for Human ITPase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the ITPA gene."
Lin S. , McLennan A.G. , Ying K. , Wang Z. , Gu S. , Jin H. , Wu C. , Lu W. , Yuan Y. , Tang R. , Xie Y. , Mao Y.
J. Biol. Chem.276:18695-18701(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBUNIT;SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES
tissue: Fetal brain.
2.

Mao Y.M. , Xie Y. , Zheng Z.H.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ITPAD THR-32
tissue: Fetal brain.
3.

"Molecular cloning of cDNA associated with human lung cancer antigen and study on its functions."
Fan M.-Z. , Chen Z. , Cao Z.-M.
Submitted (2001-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Lung carcinoma.
4.

Danaei Y. , Behmanesh M. , Sadeghi Zadeh M.
Submitted (2006-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
5.

"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
Shichijo S. , Itoh K.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon adenocarcinoma.
6.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Lung carcinoma.
tissue: Neuroblastoma.
9.

Bienvenut W.V. , Waridel P. , Quadroni M.
Submitted (2009-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-9; 40-56; 95-110 AND 181-194;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Embryonic kidney.
10.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 10-56 AND 95-130;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
11.

"Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase."
Burgis N.E. , Cunningham R.P.
J. Biol. Chem.282:3531-3538(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBSTRATE SPECIFICITY;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase."
Porta J. , Kolar C. , Kozmin S.G. , Pavlov Y.I. , Borgstahl G.E.
Acta Crystallogr. F62:1076-1081(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS)
14.

"Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T."
Stenmark P. , Kursula P. , Flodin S. , Graslund S. , Landry R. , Nordlund P. , Schueler H.
J. Biol. Chem.282:3182-3187(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) ALONE AND IN COMPLEX WITH ITP;COFACTOR;MAGNESIUM-BINDING SITES;SUBSTRATE-BINDING SITES
15.

"Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency."
Sumi S. , Marinaki A.M. , Arenas M. , Fairbanks L. , Shobowale-Bakre M. , Rees D.C. , Thein S.L. , Ansari A. , Sanderson J. , De Abreu R.A. , Simmonds H.A. , Duley J.A.
Hum. Genet.111:360-367(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ITPAD THR-32
16.

"DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency."
Cao H. , Hegele R.A.
J. Hum. Genet.47:620-622(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ITPAD THR-32

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