Itpr1 ELISA Kit for Mouse(Mus musculus) | EIAab.comItpr1 ELISA Kit for Mouse(Mus musculus)

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Itpr1 (Gene name),

Inositol 1,4,5-trisphosphate receptor type 1 (Protein name ), ITPR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Itpr1(Insp3r;Pcd6;Pcp1);

Protein name:

Inositol 1,4,5-trisphosphate receptor type 1;

Alternative:

Inositol 1,4,5-trisphosphate-binding protein P400;IP3 receptor isoform 1(IP3R 1;InsP3R1);Purkinje cell protein 1;Protein PCD-6;Type 1 inositol 1,4,5-trisphosphate receptor(Type 1 InsP3 receptor);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with ERP44 in a pH-, redox state-and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with AHCYL1 and MRVI1. Interacts with CABP1.

Function:

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2749

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2749:

LESTMKLVTN | LSGQLSELKD | QMTEQRKQKQ | RIGLLGHPPH | MNVNPQQPA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:16438

UniGene:

Mm.227912

SMR:

P11881

String:

P11881

Pfam:

PF08709

Uniprot:

P11881

FOR

ELISA Kit for Mouse Inositol 1,4,5-trisphosphate receptor type 1

CLIA Kit for Mouse Inositol 1,4,5-trisphosphate receptor type 1

Polyclonal Antibody for Mouse Inositol 1,4,5-trisphosphate receptor type 1

Monoclonal Antibody for Mouse Inositol 1,4,5-trisphosphate receptor type 1

Protein for Mouse Inositol 1,4,5-trisphosphate receptor type 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400."
Furuichi T. , Yoshikawa S. , Miyawaki A. , Wada K. , Maeda N. , Mikoshiba K.
Nature342:32-38(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
tissue: Purkinje cell.
2.

"Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum."
Furuichi T. , Yoshikawa S. , Mikoshiba K.
Nucleic Acids Res.17:5385-5386(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: ICR.
tissue: Cerebellum.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner."
Nakagawa T. , Okano H. , Furuichi T. , Aruga J. , Mikoshiba K.
Proc. Natl. Acad. Sci. U.S.A.88:6244-6248(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-332 AND 1692-1731;ALTERNATIVE SPLICING
strain: ICR.
5.

Lubec G. , Kang S.U.
Submitted (2007-04) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 862-871;IDENTIFICATION BY MASS SPECTROMETRY
strain: C57BL/6.
tissue: Brain.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2098-2749
7.

"cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons."
Nordquist D.T. , Kozak C.A. , Orr H.T.
J. Neurosci.8:4780-4789(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2250-2749
strain: C57BL/6J.
tissue: Cerebellum.
8.

"IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor."
Ando H. , Mizutani A. , Matsu-ura T. , Mikoshiba K.
J. Biol. Chem.278:10602-10612(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AHCYL1
9.

"Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44."
Higo T. , Hattori M. , Nakamura T. , Natsume T. , Michikawa T. , Mikoshiba K.
Cell120:85-98(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERP44;MUTAGENESIS OF CYS-2496; CYS-2504 AND CYS-2527
10.

"Binding of IRBIT to the IP3 receptor: determinants and functional effects."
Devogelaere B. , Nadif Kasri N. , Derua R. , Waelkens E. , Callewaert G. , Missiaen L. , Parys J.B. , De Smedt H.
Biochem. Biophys. Res. Commun.343:49-56(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AHCYL1
11.

"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1588;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
12.

"Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis."
Li G. , Mongillo M. , Chin K.T. , Harding H. , Ron D. , Marks A.R. , Tabas I.
J. Cell Biol.186:783-792(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening."
Yamazaki H. , Chan J. , Ikura M. , Michikawa T. , Mikoshiba K.
J. Biol. Chem.285:36081-36091(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF TYR-167 AND LYS-168
14.

"Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes."
Matsuzaki H. , Fujimoto T. , Ota T. , Ogawa M. , Tsunoda T. , Doi K. , Hamabashiri M. , Tanaka M. , Shirasawa S.
FEBS Open Bio2:255-259(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TESPA1
15.

"Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand."
Bosanac I. , Alattia J.R. , Mal T.K. , Chan J. , Talarico S. , Tong F.K. , Tong K.I. , Yoshikawa F. , Furuichi T. , Iwai M. , Michikawa T. , Mikoshiba K. , Ikura M.
Nature420:696-700(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 224-604 IN COMPLEX WITH INOSITOL 1,4,5-TRISPHOSPHATE;MUTAGENESIS OF THR-267 AND TYR-567
16.

"Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor."
Bosanac I. , Yamazaki H. , Matsu-Ura T. , Michikawa T. , Mikoshiba K. , Ikura M.
Mol. Cell17:193-203(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 2-223
17.

"IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation."
Antl M. , von Bruehl M.-L. , Eiglsperger C. , Werner M. , Konrad I. , Kocher T. , Wilm M. , Hofmann F. , Massberg S. , Schlossmann J.
Blood109:552-559(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MRVI1

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