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Index > Protein center > ITSN1(Gene name) > Human
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  • ITSN1 (Gene name),
  • Intersectin-1 (Protein name ),  ITSN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ITSN1(ITSN;SH3D1A);
    Protein name:
    Intersectin-1;
    Alternative:
    SH3P17;SH3 domain-containing protein 1A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Also binds clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2 and STON2 (By similarity). Interacts with ARHGAP31. Interacts with ADAM15.
    Function:
    Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
    Subcellular Location:
    Endomembrane system Cell junction synapse synaptosome Cell projection lamellipodium
    Protein Attributes:
    Sequence length:
    1721
    Sequence:
    50:
    MAQFPTPFGG | SLDIWAITVE | ERAKHDQQFH | SLKPISGFIT | GDQARNFFFQ | 
    100:
    SGLPQPVLAQ | IWALADMNND | GRMDQVEFSI | AMKLIKLKLQ | GYQLPSALPP | 
    150:
    VMKQQPVAIS | SAPAFGMGGI | ASMPPLTAVA | PVPMGSIPVV | GMSPTLVSSV | 
    200:
    PTAAVPPLAN | GAPPVIQPLP | AFAHPAATLP | KSSSFSRSGP | GSQLNTKLQK | 
    250:
    AQSFDVASVP | PVAEWAVPQS | SRLKYRQLFN | SHDKTMSGHL | TGPQARTILM | 
    300:
    QSSLPQAQLA | SIWNLSDIDQ | DGKLTAEEFI | LAMHLIDVAM | SGQPLPPVLP | 
    350:
    PEYIPPSFRR | VRSGSGISVI | SSTSVDQRLP | EEPVLEDEQQ | QLEKKLPVTF | 
    400:
    EDKKRENFER | GNLELEKRRQ | ALLEQQRKEQ | ERLAQLERAE | QERKERERQE | 
    450:
    QERKRQLELE | KQLEKQRELE | RQREEERRKE | IERREAAKRE | LERQRQLEWE | 
    500:
    RNRRQELLNQ | RNKEQEDIVV | LKAKKKTLEF | ELEALNDKKH | QLEGKLQDIR | 
    550:
    CRLTTQRQEI | ESTNKSRELR | IAEITHLQQQ | LQESQQMLGR | LIPEKQILND | 
    600:
    QLKQVQQNSL | HRDSLVTLKR | ALEAKELARQ | HLRDQLDEVE | KETRSKLQEI | 
    650:
    DIFNNQLKEL | REIHNKQQLQ | KQKSMEAERL | KQKEQERKII | ELEKQKEEAQ | 
    700:
    RRAQERDKQW | LEHVQQEDEH | QRPRKLHEEE | KLKREESVKK | KDGEEKGKQE | 
    750:
    AQDKLGRLFH | QHQEPAKPAV | QAPWSTAEKG | PLTISAQENV | KVVYYRALYP | 
    800:
    FESRSHDEIT | IQPGDIVMVK | GEWVDESQTG | EPGWLGGELK | GKTGWFPANY | 
    850:
    AEKIPENEVP | APVKPVTDST | SAPAPKLALR | ETPAPLAVTS | SEPSTTPNNW | 
    900:
    ADFSSTWPTS | TNEKPETDNW | DAWAAQPSLT | VPSAGQLRQR | SAFTPATATG | 
    950:
    SSPSPVLGQG | EKVEGLQAQA | LYPWRAKKDN | HLNFNKNDVI | TVLEQQDMWW | 
    1000:
    FGEVQGQKGW | FPKSYVKLIS | GPIRKSTSMD | SGSSESPASL | KRVASPAAKP | 
    1050:
    VVSGEEFIAM | YTYESSEQGD | LTFQQGDVIL | VTKKDGDWWT | GTVGDKAGVF | 
    1100:
    PSNYVRLKDS | EGSGTAGKTG | SLGKKPEIAQ | VIASYTATGP | EQLTLAPGQL | 
    1150:
    ILIRKKNPGG | WWEGELQARG | KKRQIGWFPA | NYVKLLSPGT | SKITPTEPPK | 
    1200:
    STALAAVCQV | IGMYDYTAQN | DDELAFNKGQ | IINVLNKEDP | DWWKGEVNGQ | 
    1250:
    VGLFPSNYVK | LTTDMDPSQQ | WCSDLHLLDM | LTPTERKRQG | YIHELIVTEE | 
    1300:
    NYVNDLQLVT | EIFQKPLMES | ELLTEKEVAM | IFVNWKELIM | CNIKLLKALR | 
    1350:
    VRKKMSGEKM | PVKMIGDILS | AQLPHMQPYI | RFCSRQLNGA | ALIQQKTDEA | 
    1400:
    PDFKEFVKRL | AMDPRCKGMP | LSSFILKPMQ | RVTRYPLIIK | NILENTPENH | 
    1450:
    PDHSHLKHAL | EKAEELCSQV | NEGVREKENS | DRLEWIQAHV | QCEGLSEQLV | 
    1500:
    FNSVTNCLGP | RKFLHSGKLY | KAKSNKELYG | FLFNDFLLLT | QITKPLGSSG | 
    1550:
    TDKVFSPKSN | LQYKMYKTPI | FLNEVLVKLP | TDPSGDEPIF | HISHIDRVYT | 
    1600:
    LRAESINERT | AWVQKIKAAS | ELYIETEKKK | REKAYLVRSQ | RATGIGRLMV | 
    1650:
    NVVEGIELKP | CRSHGKSNPY | CEVTMGSQCH | ITKTIQDTLN | PKWNSNCQFF | 
    1700:
    IRDLEQEVLC | ITVFERDQFS | PDDFLGRTEI | RVADIKKDQG | SKGPVTKCLL | 
    1721:
    LHEVPTGEIV | VRLDLQLFDE | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Intersectin-1
    ELISA Kit for Human Intersectin-1
    ELISA Kit for Human Intersectin-1
    CLIA Kit for Human Intersectin-1
    CLIA Kit for Human Intersectin-1
    CLIA Kit for Human Intersectin-1
    Polyclonal Antibody for Human Intersectin-1
    Polyclonal Antibody for Human Intersectin-1
    Polyclonal Antibody for Human Intersectin-1
    Monoclonal Antibody for Human Intersectin-1
    Monoclonal Antibody for Human Intersectin-1
    Monoclonal Antibody for Human Intersectin-1
    Protein for Human Intersectin-1
    Protein for Human Intersectin-1
    Protein for Human Intersectin-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon."
      Guipponi M. , Scott H.S. , Chen H. , Schebesta A. , Rossier C. , Antonarakis S.E.
      Genomics53:369-376(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANT ASN-1137
      tissue: Fetal brain.
    2. 2.
      "Alu-splice cloning of human intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome."
      Pucharcos C. , Fuentes J.-J. , Casas C. , de la Luna S. , Alcantara S. , Arbones M.L. , Soriano E. , Estivill X. , Pritchard M.
      Eur. J. Hum. Genet.7:704-712(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "Structural diversity and differential expression of novel human intersectin 1 isoforms."
      Kropyvko S. , Gerasymchuk D. , Skrypkina I. , Dergai M. , Dergai O. , Nikolaienko O. , Rynditch A. , Tsyba L.
      Mol. Biol. Rep.37:2789-2796(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8; 9; 10; 11 AND 12);VARIANT ASN-1137;ALTERNATIVE SPLICING
      tissue: Brain.
      tissue: Lung.
    4. 4.
      "Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1."
      Dergai M. , Skrypkina I. , Dergai O. , Tsyba L. , Novokhatska O. , Filonenko V. , Drobot L. , Rynditch A.
      Gene485:120-129(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
      tissue: Kidney.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      tissue: Placenta.
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Embryonic stem cell.
    7. 8.
      "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
      Sparks A.B. , Hoffman N.G. , McConnell S.J. , Fowlkes D.M. , Kay B.K.
      Nat. Biotechnol.14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 620-1721 (ISOFORM 3)
      tissue: Bone marrow.
    8. 9.
      "Mouse homologs of human chromosome 21 genes."
      Tsyba L.O. , Kvasha S.M. , Skripkina I.Y. , Anoprienko O.V. , Slavov D. , Tassone F. , Rynditch A.V. , Gardiner K.
      Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 963-1721 (ISOFORM 3)
      tissue: Brain.
    9. 10.
      "The human intersectin genes and their spliced variants are differentially expressed."
      Pucharcos C. , Casas C. , Nadal M. , Estivill X. , de la Luna S.
      Biochim. Biophys. Acta1521:1-11(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
      tissue: Brain.
      tissue: Fetal liver.
    10. 11.
      "The SH3D1A gene maps to human chromosome 21q22.1-->q22.2."
      Chen H. , Antonarakis S.E.
      Cytogenet. Cell Genet.78:213-215(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE MAPPING
    11. 12.
      "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin."
      Jenna S. , Hussain N.K. , Danek E.I. , Triki I. , Wasiak S. , McPherson P.S. , Lamarche-Vane N.
      J. Biol. Chem.277:6366-6373(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ARHGAP31;SUBCELLULAR LOCATION
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-904;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 15.
      "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
      Kleino I. , Ortiz R.M. , Yritys M. , Huovila A.P. , Saksela K.
      J. Cell. Biochem.108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAM15
    15. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 17.
      "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits."
      Dergai O. , Novokhatska O. , Dergai M. , Skrypkina I. , Tsyba L. , Moreau J. , Rynditch A.
      Biochem. Biophys. Res. Commun.402:408-413(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH REPS1 AND SGIP1;SUBCELLULAR LOCATION
    17. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      "FCHo proteins are nucleators of clathrin-mediated endocytosis."
      Henne W.M. , Boucrot E. , Meinecke M. , Evergren E. , Vallis Y. , Mittal R. , McMahon H.T.
      Science328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO2
    19. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 21.
      "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."
      Teckchandani A. , Mulkearns E.E. , Randolph T.W. , Toida N. , Cooper J.A.
      Mol. Biol. Cell23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DAB2
    21. 22.
      "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
      Umasankar P.K. , Sanker S. , Thieman J.R. , Chakraborty S. , Wendland B. , Tsang M. , Traub L.M.
      Nat. Cell Biol.14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO1
    22. 23.
      "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors."
      Snyder J.T. , Worthylake D.K. , Rossman K.L. , Betts L. , Pruitt W.M. , Siderovski D.P. , Der C.J. , Sondek J.
      Nat. Struct. Biol.9:468-475(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1229-1581 IN COMPLEX WITH CDC42;MUTAGENESIS OF MET-1369 AND LEU-1376
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