Gene name:
ITSN1 (ITSN;SH3D1A) ;
Protein name:
Intersectin-1 ;
Alternative:
SH3P17 ;SH3 domain-containing protein 1A ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with dynamin, CDC42, SNAP25 and SNAP23. Clusters several dynamin in a manner that is regulated by alternative splicing. Also binds clathrin-associated proteins and other components of the endocytic machinery, such as SPIN90, EPS15, EPN1, EPN2 and STON2 (By similarity). Interacts with ARHGAP31. Interacts with ADAM15.
Function:
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.
Subcellular Location:
Endomembrane system
Cell junction
synapse
synaptosome
Cell projection
lamellipodium
Protein Attributes:
50:
MAQFPTPFGG | SLDIWAITVE | ERAKHDQQFH | SLKPISGFIT | GDQARNFFFQ |
100:
SGLPQPVLAQ | IWALADMNND | GRMDQVEFSI | AMKLIKLKLQ | GYQLPSALPP |
150:
VMKQQPVAIS | SAPAFGMGGI | ASMPPLTAVA | PVPMGSIPVV | GMSPTLVSSV |
200:
PTAAVPPLAN | GAPPVIQPLP | AFAHPAATLP | KSSSFSRSGP | GSQLNTKLQK |
250:
AQSFDVASVP | PVAEWAVPQS | SRLKYRQLFN | SHDKTMSGHL | TGPQARTILM |
300:
QSSLPQAQLA | SIWNLSDIDQ | DGKLTAEEFI | LAMHLIDVAM | SGQPLPPVLP |
350:
PEYIPPSFRR | VRSGSGISVI | SSTSVDQRLP | EEPVLEDEQQ | QLEKKLPVTF |
400:
EDKKRENFER | GNLELEKRRQ | ALLEQQRKEQ | ERLAQLERAE | QERKERERQE |
450:
QERKRQLELE | KQLEKQRELE | RQREEERRKE | IERREAAKRE | LERQRQLEWE |
500:
RNRRQELLNQ | RNKEQEDIVV | LKAKKKTLEF | ELEALNDKKH | QLEGKLQDIR |
550:
CRLTTQRQEI | ESTNKSRELR | IAEITHLQQQ | LQESQQMLGR | LIPEKQILND |
600:
QLKQVQQNSL | HRDSLVTLKR | ALEAKELARQ | HLRDQLDEVE | KETRSKLQEI |
650:
DIFNNQLKEL | REIHNKQQLQ | KQKSMEAERL | KQKEQERKII | ELEKQKEEAQ |
700:
RRAQERDKQW | LEHVQQEDEH | QRPRKLHEEE | KLKREESVKK | KDGEEKGKQE |
750:
AQDKLGRLFH | QHQEPAKPAV | QAPWSTAEKG | PLTISAQENV | KVVYYRALYP |
800:
FESRSHDEIT | IQPGDIVMVK | GEWVDESQTG | EPGWLGGELK | GKTGWFPANY |
850:
AEKIPENEVP | APVKPVTDST | SAPAPKLALR | ETPAPLAVTS | SEPSTTPNNW |
900:
ADFSSTWPTS | TNEKPETDNW | DAWAAQPSLT | VPSAGQLRQR | SAFTPATATG |
950:
SSPSPVLGQG | EKVEGLQAQA | LYPWRAKKDN | HLNFNKNDVI | TVLEQQDMWW |
1000:
FGEVQGQKGW | FPKSYVKLIS | GPIRKSTSMD | SGSSESPASL | KRVASPAAKP |
1050:
VVSGEEFIAM | YTYESSEQGD | LTFQQGDVIL | VTKKDGDWWT | GTVGDKAGVF |
1100:
PSNYVRLKDS | EGSGTAGKTG | SLGKKPEIAQ | VIASYTATGP | EQLTLAPGQL |
1150:
ILIRKKNPGG | WWEGELQARG | KKRQIGWFPA | NYVKLLSPGT | SKITPTEPPK |
1200:
STALAAVCQV | IGMYDYTAQN | DDELAFNKGQ | IINVLNKEDP | DWWKGEVNGQ |
1250:
VGLFPSNYVK | LTTDMDPSQQ | WCSDLHLLDM | LTPTERKRQG | YIHELIVTEE |
1300:
NYVNDLQLVT | EIFQKPLMES | ELLTEKEVAM | IFVNWKELIM | CNIKLLKALR |
1350:
VRKKMSGEKM | PVKMIGDILS | AQLPHMQPYI | RFCSRQLNGA | ALIQQKTDEA |
1400:
PDFKEFVKRL | AMDPRCKGMP | LSSFILKPMQ | RVTRYPLIIK | NILENTPENH |
1450:
PDHSHLKHAL | EKAEELCSQV | NEGVREKENS | DRLEWIQAHV | QCEGLSEQLV |
1500:
FNSVTNCLGP | RKFLHSGKLY | KAKSNKELYG | FLFNDFLLLT | QITKPLGSSG |
1550:
TDKVFSPKSN | LQYKMYKTPI | FLNEVLVKLP | TDPSGDEPIF | HISHIDRVYT |
1600:
LRAESINERT | AWVQKIKAAS | ELYIETEKKK | REKAYLVRSQ | RATGIGRLMV |
1650:
NVVEGIELKP | CRSHGKSNPY | CEVTMGSQCH | ITKTIQDTLN | PKWNSNCQFF |
1700:
IRDLEQEVLC | ITVFERDQFS | PDDFLGRTEI | RVADIKKDQG | SKGPVTKCLL |
1721:
LHEVPTGEIV | VRLDLQLFDE | P
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Intersectin-1
ELISA Kit for Human Intersectin-1
ELISA Kit for Human Intersectin-1
CLIA Kit for Human Intersectin-1
CLIA Kit for Human Intersectin-1
CLIA Kit for Human Intersectin-1
Polyclonal Antibody for Human Intersectin-1
Polyclonal Antibody for Human Intersectin-1
Polyclonal Antibody for Human Intersectin-1
Monoclonal Antibody for Human Intersectin-1
Monoclonal Antibody for Human Intersectin-1
Monoclonal Antibody for Human Intersectin-1
Protein for Human Intersectin-1
Protein for Human Intersectin-1
Protein for Human Intersectin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 6; 7; 8; 9; 10; 11 AND 12);VARIANT ASN-1137;ALTERNATIVE SPLICING
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
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Kidney .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
tissue :
Placenta .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Embryonic stem cell .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 620-1721 (ISOFORM 3)
tissue :
Bone marrow .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 963-1721 (ISOFORM 3)
tissue :
Brain .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
tissue :
Brain .
tissue :
Fetal liver .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GENE MAPPING
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ARHGAP31;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-902 AND SER-904;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ADAM15
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH REPS1 AND SGIP1;SUBCELLULAR LOCATION
18.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FCHO2
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DAB2
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FCHO1
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1229-1581 IN COMPLEX WITH CDC42;MUTAGENESIS OF MET-1369 AND LEU-1376