ITSN2 ELISA Kit for Human(Homo sapiens) | EIAab.comITSN2 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ITSN2 (Gene name),

Intersectin-2 (Protein name ), ITSN2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

ITSN2(KIAA1256;SH3D1B;SWAP);

Protein name:

Intersectin-2;

Alternative:

SH3P18;SH3 domain-containing protein 1B;SH3P18-like WASP-associated protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Belongs to a complex that may contain multimers of ITSN1, ITSN2 and EPS15, and different partners according to the step in the endocytic process. Interacts with ADAM15. Interacts with FASLG.

Function:

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1697

Sequence:

50:

MMAQFPTAMN | GGPNMWAITS | EERTKHDRQF | DNLKPSGGYI | TGDQARNFFL |

100:

QSGLPAPVLA | EIWALSDLNK | DGKMDQQEFS | IAMKLIKLKL | QGQQLPVVLP |

150:

PIMKQPPMFS | PLISARFGMG | SMPNLSIPQP | LPPAAPITSL | SSATSGTNLP |

200:

PLMMPTPLVP | SVSTSSLPNG | TASLIQPLPI | PYSSSTLPHG | SSYSLMMGGF |

250:

GGASIQKAQS | LIDLGSSSST | SSTASLSGNS | PKTGTSEWAV | PQPTRLKYRQ |

300:

KFNTLDKSMS | GYLSGFQARN | ALLQSNLSQT | QLATIWTLAD | VDGDGQLKAE |

350:

EFILAMHLTD | MAKAGQPLPL | TLPPELVPPS | FRGGKQIDSI | NGTLPSYQKM |

400:

QEEEPQKKLP | VTFEDKRKAN | YERGNMELEK | RRQALMEQQQ | REAERKAQKE |

450:

KEEWERKQRE | LQEQEWKKQL | ELEKRLEKQR | ELERQREEER | RKDIERREAA |

500:

KQELERQRRL | EWERIRRQEL | LNQKNREQEE | IVRLNSKKKN | LHLELEALNG |

550:

KHQQISGRLQ | DVRLKKQTQK | TELEVLDKQC | DLEIMEIKQL | QQELQEYQNK |

600:

LIYLVPEKQL | LNERIKNMQF | SNTPDSGVSL | LHKKSLEKEE | LCQRLKEQLD |

650:

ALEKETASKL | SEMDSFNNQL | KCGNMDDSVL | QCLLSLLSCL | NNLFLLLKEL |

700:

RETYNTQQLA | LEQLYKIKRD | KLKEIERKRL | ELMQKKKLED | EAARKAKQGK |

750:

ENLWKENLRK | EEEEKQKRLQ | EEKTQEKIQE | EERKAEEKQR | KDKDTLKAEE |

800:

KKRETASVLV | NYRALYPFEA | RNHDEMSFNS | GDIIQVDEKT | VGEPGWLYGS |

850:

FQGNFGWFPC | NYVEKMPSSE | NEKAVSPKKA | LLPPTVSLSA | TSTSSEPLSS |

900:

NQPASVTDYQ | NVSFSNLTVN | TSWQKKSAFT | RTVSPGSVSP | IHGQGQVVEN |

950:

LKAQALCSWT | AKKDNHLNFS | KHDIITVLEQ | QENWWFGEVH | GGRGWFPKSY |

1000:

VKIIPGSEVK | REEPEALYAA | VNKKPTSAAY | SVGEEYIALY | PYSSVEPGDL |

1050:

TFTEGEEILV | TQKDGEWWTG | SIGDRSGIFP | SNYVKPKDQE | SFGSASKSGA |

1100:

SNKKPEIAQV | TSAYVASGSE | QLSLAPGQLI | LILKKNTSGW | WQGELQARGK |

1150:

KRQKGWFPAS | HVKLLGPSSE | RATPAFHPVC | QVIAMYDYAA | NNEDELSFSK |

1200:

GQLINVMNKD | DPDWWQGEIN | GVTGLFPSNY | VKMTTDSDPS | QQWCADLQTL |

1250:

DTMQPIERKR | QGYIHELIQT | EERYMADLQL | VVEVFQKRMA | ESGFLTEGEM |

1300:

ALIFVNWKEL | IMSNTKLLKA | LRVRKKTGGE | KMPVQMIGDI | LAAELSHMQA |

1350:

YIRFCSCQLN | GAALLQQKTD | EDTDFKEFLK | KLASDPRCKG | MPLSSFLLKP |

1400:

MQRITRYPLL | IRSILENTPE | SHADHSSLKL | ALERAEELCS | QVNEGVREKE |

1450:

NSDRLEWIQA | HVQCEGLAEQ | LIFNSLTNCL | GPRKLLHSGK | LYKTKSNKEL |

1500:

HGFLFNDFLL | LTYMVKQFAV | SSGSEKLFSS | KSNAQFKMYK | TPIFLNEVLV |

1550:

KLPTDPSSDE | PVFHISHIDR | VYTLRTDNIN | ERTAWVQKIK | AASEQYIDTE |

1600:

KKKREKAYQA | RSQKTSGIGR | LMVHVIEATE | LKACKPNGKS | NPYCEISMGS |

1650:

QSYTTRTIQD | TLNPKWNFNC | QFFIKDLYQD | VLCLTLFDRD | QFSPDDFLGR |

1697:

TEIPVAKIRT | EQESKGPMTR | RLLLHEVPTG | EVWVRFDLQL | FEQKTLL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

SMR:

String:

STRING:

9606.ENSP00000347244

Pfam:

UniGene:

KEGG:

Uniprot:

FOR

ELISA Kit for Human Intersectin-2

ELISA Kit for Human Intersectin-2

CLIA Kit for Human Intersectin-2

CLIA Kit for Human Intersectin-2

Polyclonal Antibody for Human Intersectin-2

Polyclonal Antibody for Human Intersectin-2

Monoclonal Antibody for Human Intersectin-2

Monoclonal Antibody for Human Intersectin-2

Protein for Human Intersectin-2

Protein for Human Intersectin-2

R&D Technical Data

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Precision

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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References

1.

"Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis."
Pucharcos C. , Estivill X. , de la Luna S.
FEBS Lett.478:43-51(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
tissue: Fetal brain.
tissue: Fetal liver.
2.

"Intersectin 2 (SH3D1B), human homolog of mouse Ese2 protein."
Seifert M. , Engel M. , Welter C.
Submitted (2000-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Kikuno R. , Hirosawa M. , Nomura N. , Ohara O.
DNA Res.6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-721 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1262-1697;VARIANT ILE-291
tissue: Embryo.
6.

"SH3P18-like wasp associated protein (SWAP): a multiple SH3 domain containing protein that interacts with WASP."
Wilson L.A. , Fields D. , Cruz L. , Friesen J. , Siminovitch K.A.
Submitted (1997-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 822-1285 (ISOFORM 1)
7.

"Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."
Sparks A.B. , Hoffman N.G. , McConnell S.J. , Fowlkes D.M. , Kay B.K.
Nat. Biotechnol.14:741-744(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 945-1192 (ISOFORM 4)
tissue: Bone marrow.
8.

"The human intersectin genes and their spliced variants are differentially expressed."
Pucharcos C. , Casas C. , Nadal M. , Estivill X. , de la Luna S.
Biochim. Biophys. Acta1521:1-11(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
tissue: Brain.
tissue: Fetal liver.
9.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-968;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
10.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-968;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-889;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
Voss M. , Lettau M. , Janssen O.
BMC Immunol.10:53-53(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FASLG
14.

"Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
Kleino I. , Ortiz R.M. , Yritys M. , Huovila A.P. , Saksela K.
J. Cell. Biochem.108:877-885(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAM15
15.

"Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits."
Mettlen M. , Stoeber M. , Loerke D. , Antonescu C.N. , Danuser G. , Schmid S.L.
Mol. Biol. Cell20:3251-3260(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210; SER-889 AND TYR-968;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
17.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230; THR-573; SER-889 AND TYR-968;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
18.

"FCHo proteins are nucleators of clathrin-mediated endocytosis."
Henne W.M. , Boucrot E. , Meinecke M. , Evergren E. , Vallis Y. , Mittal R. , McMahon H.T.
Science328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO2
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."
Teckchandani A. , Mulkearns E.E. , Randolph T.W. , Toida N. , Cooper J.A.
Mol. Biol. Cell23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"Solution structure of SH3 domains of human intersectin 2 (KIAA1256)."
RIKEN structural genomics initiative (RSGI)
Submitted (2004-08) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 762-1187

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