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Index > Protein center > JAK2(Gene name) > Human
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  • JAK2 (Gene name),
  • Tyrosine-protein kinase JAK2 (Protein name ),  JAK2_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    JAK2;
    Protein name:
    Tyrosine-protein kinase JAK2;
    Alternative:
    Janus kinase 2(JAK-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with EPOR, SIRPA, SH2B1 and TEC (By similarity). Interacts with IL23R, SKB1 and STAM2.
    Function:
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
    Subcellular Location:
    Endomembrane system Peripheral membrane protein Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    1132
    Sequence:
    50:
    MGMACLTMTE | MEGTSTSSIY | QNGDISGNAN | SMKQIDPVLQ | VYLYHSLGKS | 
    100:
    EADYLTFPSG | EYVAEEICIA | ASKACGITPV | YHNMFALMSE | TERIWYPPNH | 
    150:
    VFHIDESTRH | NVLYRIRFYF | PRWYCSGSNR | AYRHGISRGA | EAPLLDDFVM | 
    200:
    SYLFAQWRHD | FVHGWIKVPV | THETQEECLG | MAVLDMMRIA | KENDQTPLAI | 
    250:
    YNSISYKTFL | PKCIRAKIQD | YHILTRKRIR | YRFRRFIQQF | SQCKATARNL | 
    300:
    KLKYLINLET | LQSAFYTEKF | EVKEPGSGPS | GEEIFATIII | TGNGGIQWSR | 
    350:
    GKHKESETLT | EQDLQLYCDF | PNIIDVSIKQ | ANQEGSNESR | VVTIHKQDGK | 
    400:
    NLEIELSSLR | EALSFVSLID | GYYRLTADAH | HYLCKEVAPP | AVLENIQSNC | 
    450:
    HGPISMDFAI | SKLKKAGNQT | GLYVLRCSPK | DFNKYFLTFA | VERENVIEYK | 
    500:
    HCLITKNENE | EYNLSGTKKN | FSSLKDLLNC | YQMETVRSDN | IIFQFTKCCP | 
    550:
    PKPKDKSNLL | VFRTNGVSDV | PTSPTLQRPT | HMNQMVFHKI | RNEDLIFNES | 
    600:
    LGQGTFTKIF | KGVRREVGDY | GQLHETEVLL | KVLDKAHRNY | SESFFEAASM | 
    650:
    MSKLSHKHLV | LNYGVCVCGD | ENILVQEFVK | FGSLDTYLKK | NKNCINILWK | 
    700:
    LEVAKQLAWA | MHFLEENTLI | HGNVCAKNIL | LIREEDRKTG | NPPFIKLSDP | 
    750:
    GISITVLPKD | ILQERIPWVP | PECIENPKNL | NLATDKWSFG | TTLWEICSGG | 
    800:
    DKPLSALDSQ | RKLQFYEDRH | QLPAPKWAEL | ANLINNCMDY | EPDFRPSFRA | 
    850:
    IIRDLNSLFT | PDYELLTEND | MLPNMRIGAL | GFSGAFEDRD | PTQFEERHLK | 
    900:
    FLQQLGKGNF | GSVEMCRYDP | LQDNTGEVVA | VKKLQHSTEE | HLRDFEREIE | 
    950:
    ILKSLQHDNI | VKYKGVCYSA | GRRNLKLIME | YLPYGSLRDY | LQKHKERIDH | 
    1000:
    IKLLQYTSQI | CKGMEYLGTK | RYIHRDLATR | NILVENENRV | KIGDFGLTKV | 
    1050:
    LPQDKEYYKV | KEPGESPIFW | YAPESLTESK | FSVASDVWSF | GVVLYELFTY | 
    1100:
    IEKSKSPPAE | FMRMIGNDKQ | GQMIVFHLIE | LLKNNGRLPR | PDGCPDEIYM | 
    1132:
    IMTECWNNNV | NQRPSFRDLA | LRVDQIRDNM | AG
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tyrosine-protein kinase JAK2
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    E9140h
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    ELISA Kit for Human Tyrosine-protein kinase JAK2
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    ELISA Kit for Human Tyrosine-protein kinase JAK2
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    ELISA Kit for Human Tyrosine-protein kinase JAK2
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    E9140r
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    ELISA Kit for Human Tyrosine-protein kinase JAK2
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    CLIA Kit for Human Tyrosine-protein kinase JAK2
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    U9140r
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    CLIA Kit for Human Tyrosine-protein kinase JAK2
    Cat.:
    U9140m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tyrosine-protein kinase JAK2
    MSDS:
    Please sign in first.
    CLIA Kit for Human Tyrosine-protein kinase JAK2
    Cat.:
    U9140h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Tyrosine-protein kinase JAK2
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    U9140p
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    Packing:
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    Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
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    P9140Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
    Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
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    P9140Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
    Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
    Protein for Human Tyrosine-protein kinase JAK2
    Protein for Human Tyrosine-protein kinase JAK2
    Protein for Human Tyrosine-protein kinase JAK2
    Protein for Human Tyrosine-protein kinase JAK2
    Protein for Human Tyrosine-protein kinase JAK2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue."
      Saltzman A. , Stone M. , Franks C. , Searfoss G. , Munro R. , Jaye M. , Ivashchenko Y.
      Biochem. Biophys. Res. Commun.246:627-633(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning and characterization of the human homolog of mouse Jak2."
      Dalal I. , Arpaia E. , Dadi H. , Kulkarni S. , Squire J. , Roifman C.M.
      Blood91:844-851(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia."
      Peeters P. , Raynaud S.D. , Cools J. , Wlodarska I. , Grosgeorge J. , Philip P. , Monpoux F. , Van Rompaey L. , Baens M. , Van Den Berghe H. , Marynen P.
      Blood90:2535-2540(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH ETV6
    4. 4.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity."
      Pollack B.P. , Kotenko S.V. , He W. , Izotova L.S. , Barnoski B.L. , Pestka S.
      J. Biol. Chem.274:31531-31542(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKB1
    6. 6.
      "STAM2, a new member of the STAM family, binding to the Janus kinases."
      Endo K. , Takeshita T. , Kasai H. , Sasaki Y. , Tanaka N. , Asao H. , Kikuchi K. , Yamada M. , Chenb M. , O'Shea J.J. , Sugamura K.
      FEBS Lett.477:55-61(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAM2
      tissue: Fetal brain.
    7. 7.
      "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."
      Parham C. , Chirica M. , Timans J. , Vaisberg E. , Travis M. , Cheung J. , Pflanz S. , Zhang R. , Singh K.P. , Vega F. , To W. , Wagner J. , O'Farrell A.-M. , McClanahan T.K. , Zurawski S. , Hannum C. , Gorman D. , Rennick D.M. , more...
      J. Immunol.168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IL23R
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PCM1
    9. 9.
      "PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation."
      Murati A. , Gelsi-Boyer V. , Adelaide J. , Perot C. , Talmant P. , Giraudier S. , Lode L. , Letessier A. , Delaval B. , Brunel V. , Imbert M. , Garand R. , Xerri L. , Birnbaum D. , Mozziconacci M.-J. , Chaffanet M.
      Leukemia19:1692-1696(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PCM1
    10. 10.
      "The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene."
      Bousquet M. , Quelen C. , De Mas V. , Duchayne E. , Roquefeuil B. , Delsol G. , Laurent G. , Dastugue N. , Brousset P.
      Oncogene24:7248-7252(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PCM1
    11. 11.
      "A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia."
      Bacher U. , Reiter A. , Haferlach T. , Mueller L. , Schnittger S. , Kern W. , Schoch C.
      Haematologica91:817-820(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH PCM1
    12. 12.
      "A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma."
      Adelaide J. , Perot C. , Gelsi-Boyer V. , Pautas C. , Murati A. , Copie-Bergman C. , Imbert M. , Chaffanet M. , Birnbaum D. , Mozziconacci M.-J.
      Leukemia20:536-537(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;CHROMOSOMAL TRANSLOCATION WITH PCM1
    13. 13.
      "JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin."
      Dawson M.A. , Bannister A.J. , Gottgens B. , Foster S.D. , Bartke T. , Green A.R. , Kouzarides T.
      Nature461:819-822(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    14. 14.
      "Heme controls the regulation of protein tyrosine kinases Jak2 and Src."
      Yao X. , Balamurugan P. , Arvey A. , Leslie C. , Zhang L.
      Biochem. Biophys. Res. Commun.403:30-35(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    15. 15.
      "The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure."
      Guilluy C. , Bregeon J. , Toumaniantz G. , Rolli-Derkinderen M. , Retailleau K. , Loufrani L. , Henrion D. , Scalbert E. , Bril A. , Torres R.M. , Offermanns S. , Pacaud P. , Loirand G.
      Nat. Med.16:183-190(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control."
      Jakel H. , Weinl C. , Hengst L.
      Oncogene30:3502-3512(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CDKN1B
    17. 17.
      "Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression?"
      Wallace T.A. , Sayeski P.P.
      Cell Biochem. Biophys.44:213-222(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    19. 19.
      "The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor."
      Lucet I.S. , Fantino E. , Styles M. , Bamert R. , Patel O. , Broughton S.E. , Walter M. , Burns C.J. , Treutlein H. , Wilks A.F. , Rossjohn J.
      Blood107:176-183(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 840-1132 IN COMPLEX WITH SYNTHETIC INHIBITOR;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-1007 AND TYR-1008
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PV PHE-617
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THCYT3 PHE-617
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PV PHE-617;CHARACTERIZATION OF VARIANT PV PHE-617
    24. 24.
      "A gain-of-function mutation of JAK2 in myeloproliferative disorders."
      Kralovics R. , Passamonti F. , Buser A.S. , Teo S.-S. , Tiedt R. , Passweg J.R. , Tichelli A. , Cazzola M. , Skoda R.C.
      N. Engl. J. Med.352:1779-1790(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PV PHE-617
    25. 25.
      "Case records of the Massachusetts General Hospital. Case 15-2006: a 46-year-old woman with sudden onset of abdominal distention."
      Chung R.T. , Iafrate A.J. , Amrein P.C. , Sahani D.V. , Misdraji J.
      N. Engl. J. Med.354:2166-2175(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT PHE-617 WITH SUSCEPTIBILITY BUDD-CHIARI SYNDROME
    26. 26.
      "The JAK2 V617F mutation in de novo acute myelogenous leukemias."
      Lee J.W. , Kim Y.G. , Soung Y.H. , Han K.J. , Kim S.Y. , Rhim H.S. , Min W.S. , Nam S.W. , Park W.S. , Lee J.Y. , Yoo N.J. , Lee S.H.
      Oncogene25:1434-1436(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AML ASN-607 AND PHE-617
    27. 27.
      "The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation."
      Jamieson C.H.M. , Gotlib J. , Durocher J.A. , Chao M.P. , Mariappan M.R. , Lay M. , Jones C. , Zehnder J.L. , Lilleberg S.L. , Weissman I.L.
      Proc. Natl. Acad. Sci. U.S.A.103:6224-6229(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PV PHE-617
    28. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MYELOPROLIFERATIVE DISORDER WITH ERYTHROCYTOSIS 537-PHE--LYS-539 DELINS LEU; 538-GLN-LEU-539 AND LEU-539
    29. 30.
      "Germline JAK2 mutation in a family with hereditary thrombocytosis."
      Mead A.J. , Rugless M.J. , Jacobsen S.E. , Schuh A.
      N. Engl. J. Med.366:967-969(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THCYT3 ILE-617
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