Protein name:
Tyrosine-protein kinase JAK2 ;
Alternative:
Janus kinase 2 (JAK-2) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with EPOR, SIRPA, SH2B1 and TEC (By similarity). Interacts with IL23R, SKB1 and STAM2.
Function:
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
Subcellular Location:
Endomembrane system
Peripheral membrane protein
Cytoplasm
Nucleus
Protein Attributes:
50:
MGMACLTMTE | MEGTSTSSIY | QNGDISGNAN | SMKQIDPVLQ | VYLYHSLGKS |
100:
EADYLTFPSG | EYVAEEICIA | ASKACGITPV | YHNMFALMSE | TERIWYPPNH |
150:
VFHIDESTRH | NVLYRIRFYF | PRWYCSGSNR | AYRHGISRGA | EAPLLDDFVM |
200:
SYLFAQWRHD | FVHGWIKVPV | THETQEECLG | MAVLDMMRIA | KENDQTPLAI |
250:
YNSISYKTFL | PKCIRAKIQD | YHILTRKRIR | YRFRRFIQQF | SQCKATARNL |
300:
KLKYLINLET | LQSAFYTEKF | EVKEPGSGPS | GEEIFATIII | TGNGGIQWSR |
350:
GKHKESETLT | EQDLQLYCDF | PNIIDVSIKQ | ANQEGSNESR | VVTIHKQDGK |
400:
NLEIELSSLR | EALSFVSLID | GYYRLTADAH | HYLCKEVAPP | AVLENIQSNC |
450:
HGPISMDFAI | SKLKKAGNQT | GLYVLRCSPK | DFNKYFLTFA | VERENVIEYK |
500:
HCLITKNENE | EYNLSGTKKN | FSSLKDLLNC | YQMETVRSDN | IIFQFTKCCP |
550:
PKPKDKSNLL | VFRTNGVSDV | PTSPTLQRPT | HMNQMVFHKI | RNEDLIFNES |
600:
LGQGTFTKIF | KGVRREVGDY | GQLHETEVLL | KVLDKAHRNY | SESFFEAASM |
650:
MSKLSHKHLV | LNYGVCVCGD | ENILVQEFVK | FGSLDTYLKK | NKNCINILWK |
700:
LEVAKQLAWA | MHFLEENTLI | HGNVCAKNIL | LIREEDRKTG | NPPFIKLSDP |
750:
GISITVLPKD | ILQERIPWVP | PECIENPKNL | NLATDKWSFG | TTLWEICSGG |
800:
DKPLSALDSQ | RKLQFYEDRH | QLPAPKWAEL | ANLINNCMDY | EPDFRPSFRA |
850:
IIRDLNSLFT | PDYELLTEND | MLPNMRIGAL | GFSGAFEDRD | PTQFEERHLK |
900:
FLQQLGKGNF | GSVEMCRYDP | LQDNTGEVVA | VKKLQHSTEE | HLRDFEREIE |
950:
ILKSLQHDNI | VKYKGVCYSA | GRRNLKLIME | YLPYGSLRDY | LQKHKERIDH |
1000:
IKLLQYTSQI | CKGMEYLGTK | RYIHRDLATR | NILVENENRV | KIGDFGLTKV |
1050:
LPQDKEYYKV | KEPGESPIFW | YAPESLTESK | FSVASDVWSF | GVVLYELFTY |
1100:
IEKSKSPPAE | FMRMIGNDKQ | GQMIVFHLIE | LLKNNGRLPR | PDGCPDEIYM |
1132:
IMTECWNNNV | NQRPSFRDLA | LRVDQIRDNM | AG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Pig
ELISA Kit for Human Tyrosine-protein kinase JAK2
ELISA Kit for Human Tyrosine-protein kinase JAK2
ELISA Kit for Human Tyrosine-protein kinase JAK2
ELISA Kit for Human Tyrosine-protein kinase JAK2
ELISA Kit for Human Tyrosine-protein kinase JAK2
CLIA Kit for Human Tyrosine-protein kinase JAK2
CLIA Kit for Human Tyrosine-protein kinase JAK2
CLIA Kit for Human Tyrosine-protein kinase JAK2
CLIA Kit for Human Tyrosine-protein kinase JAK2
CLIA Kit for Human Tyrosine-protein kinase JAK2
Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
Polyclonal Antibody for Human Tyrosine-protein kinase JAK2
Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
Monoclonal Antibody for Human Tyrosine-protein kinase JAK2
Protein for Human Tyrosine-protein kinase JAK2
Protein for Human Tyrosine-protein kinase JAK2
Protein for Human Tyrosine-protein kinase JAK2
Protein for Human Tyrosine-protein kinase JAK2
Protein for Human Tyrosine-protein kinase JAK2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH ETV6
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SKB1
6.
"STAM2, a new member of the STAM family, binding to the Janus kinases."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH STAM2
tissue :
Fetal brain .
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Cited for : FUNCTION;INTERACTION WITH IL23R
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Cited for : CHROMOSOMAL TRANSLOCATION WITH PCM1
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PubMed ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION WITH PCM1
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION WITH PCM1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION WITH PCM1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;CHROMOSOMAL TRANSLOCATION WITH PCM1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
15.
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Henrion D.
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Offermanns S.
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Pacaud P.
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Loirand G.
Nat. Med.16:183-190(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF CDKN1B
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
19.
"The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor."
Lucet I.S.
,
Fantino E.
,
Styles M.
,
Bamert R.
,
Patel O.
,
Broughton S.E.
,
Walter M.
,
Burns C.J.
,
Treutlein H.
,
Wilks A.F.
,
Rossjohn J.
Blood107:176-183(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 840-1132 IN COMPLEX WITH SYNTHETIC INHIBITOR;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-1007 AND TYR-1008
20.
"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders."
The cancer genome project
,
Baxter E.J.
,
Scott L.M.
,
Campbell P.J.
,
East C.
,
Fourouclas N.
,
Swanton S.
,
Vassiliou G.S.
,
Bench A.J.
,
Boyd E.M.
,
Curtin N.
,
Scott M.A.
,
Erber W.N.
,
Green A.R.
Lancet365:1054-1061(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PV PHE-617
21.
The cancer genome project
,
Baxter E.J.
,
Scott L.M.
,
Campbell P.J.
,
East C.
,
Fourouclas N.
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Swanton S.
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Vassiliou G.S.
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Bench A.J.
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,
Green A.R.
Lancet366:122-122(2005)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
22.
"Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study."
The United Kingdom myeloproliferative disorders study group
,
The medical research council adult leukaemia working party
,
The Australasian leukaemia and lymphoma group
,
Campbell P.J.
,
Scott L.M.
,
Buck G.
,
Wheatley K.
,
East C.L.
,
Marsden J.T.
,
Duffy A.
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Boyd E.M.
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Bench A.J.
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Scott M.A.
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Vassiliou G.S.
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Milligan D.W.
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Smith S.R.
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Erber W.N.
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Bareford D.
,
Wilkins B.S.
,
Reilly J.T.
,
Harrison C.N.
,
Green A.R.
more...
Lancet366:1945-1953(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT THCYT3 PHE-617
23.
"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera."
James C.
,
Ugo V.
,
Le Couedic J.-P.
,
Staerk J.
,
Delhommeau F.
,
Lacout C.
,
Garcon L.
,
Raslova H.
,
Berger R.
,
Bennaceur-Griscelli A.
,
Villeval J.L.
,
Constantinescu S.N.
,
Casadevall N.
,
Vainchenker W.
Nature434:1144-1148(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PV PHE-617;CHARACTERIZATION OF VARIANT PV PHE-617
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PV PHE-617
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION OF VARIANT PHE-617 WITH SUSCEPTIBILITY BUDD-CHIARI SYNDROME
26.
"The JAK2 V617F mutation in de novo acute myelogenous leukemias."
Lee J.W.
,
Kim Y.G.
,
Soung Y.H.
,
Han K.J.
,
Kim S.Y.
,
Rhim H.S.
,
Min W.S.
,
Nam S.W.
,
Park W.S.
,
Lee J.Y.
,
Yoo N.J.
,
Lee S.H.
Oncogene25:1434-1436(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS AML ASN-607 AND PHE-617
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PV PHE-617
28.
"JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis."
Scott L.M.
,
Tong W.
,
Levine R.L.
,
Scott M.A.
,
Beer P.A.
,
Stratton M.R.
,
Futreal P.A.
,
Erber W.N.
,
McMullin M.F.
,
Harrison C.N.
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Warren A.J.
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Gilliland D.G.
,
Lodish H.F.
,
Green A.R.
N. Engl. J. Med.356:459-468(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS MYELOPROLIFERATIVE DISORDER WITH ERYTHROCYTOSIS 537-PHE--LYS-539 DELINS LEU; 538-GLN-LEU-539 AND LEU-539
29.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
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Stephens P.
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Smith R.
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Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
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Davies H.
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Butler A.
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Buck G.
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Louis D.N.
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Goldstraw P.
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Nicholson A.G.
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Brasseur F.
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Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] ASP-127; GLN-191; ARG-346; GLU-377; VAL-393 AND HIS-1063
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT THCYT3 ILE-617