JUN ELISA Kit for Human(Homo sapiens) | EIAab.comJUN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > JUN(Gene name) > Human

JUN (Gene name),

Transcription factor AP-1 (Protein name ), JUN_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

JUN;

Protein name:

Transcription factor AP-1;

Alternative:

Proto-oncogene c-Jun;Activator protein 1(AP1);p39;V-jun avian sarcoma virus 17 oncogene homolog;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.

Function:

Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

331

Sequence:

50:

100:

150:

200:

250:

300:

331:

LREQVAQLKQ | KVMNHVNSGC | QLMLTQQLQT | F

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3725

Pfam:

PF00170

MIM:

165160

UniGene:

Hs.696684

SMR:

P05412

String:

P05412

STRING:

9606.ENSP00000360266

Uniprot:

P05412

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ELISA Kit for Human Transcription factor AP-1

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E1292m

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ELISA Kit for Human Transcription factor AP-1

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E1292r

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96T

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ELISA Kit for Human Transcription factor AP-1

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E1292h

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ELISA Kit for Human Transcription factor AP-1

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E1292b

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96T

ELISA Kit for Human Transcription factor AP-1

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E1292c

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ELISA Kit for Human Transcription factor AP-1

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E1292p

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96T

CLIA Kit for Human Transcription factor AP-1

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U1292c

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96T

CLIA Kit for Human Transcription factor AP-1

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U1292p

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96T

CLIA Kit for Human Transcription factor AP-1

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U1292b

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96T

CLIA Kit for Human Transcription factor AP-1

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U1292h

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96T

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CLIA Kit for Human Transcription factor AP-1

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U1292r

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96T

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CLIA Kit for Human Transcription factor AP-1

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U1292m

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Polyclonal Antibody for Human Transcription factor AP-1

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P1292Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Transcription factor AP-1

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P1292Rb-h

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Polyclonal Antibody for Human Transcription factor AP-1

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P1292Rb-r

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Monoclonal Antibody for Human Transcription factor AP-1

Protein for Human Transcription factor AP-1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Structure and chromosomal localization of the functional intronless human JUN protooncogene."
Hattori K. , Angel P. , le Beau M.M. , Karin M.
Proc. Natl. Acad. Sci. U.S.A.85:9148-9152(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1."
Bohmann D. , Bos T.J. , Admon A. , Nishimura T. , Vogt P.K. , Tjian R.
Science238:1386-1392(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
3.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: B-cell.
tissue: Ovary.
tissue: Testis.
tissue: Uterus.
8.

"Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity."
Boyle W.J. , Smeal T. , Defize L.H. , Angel P. , Woodgett J.R. , Karin M. , Hunter T.
Cell64:573-584(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-239; SER-243 AND SER-249 BY GSK3B
9.

"c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif."
Bannister A.J. , Gottlieb T.M. , Kouzarides T. , Jackson S.P.
Nucleic Acids Res.21:1289-1295(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-249
10.

"Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."
Enslen H. , Tokumitsu H. , Stork P.J. , Davis R.J. , Soderling T.R.
Proc. Natl. Acad. Sci. U.S.A.93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAMK4
11.

"Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene."
Kirstein M. , Sanz L. , Moscat J. , Diaz-Meco M.T. , Saus J.
J. Biol. Chem.271:18231-18236(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCF20
12.

"A new group of conserved coactivators that increase the specificity of AP-1 transcription factors."
Claret F.-X. , Hibi M. , Dhut S. , Toda T. , Karin M.
Nature383:453-457(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
13.

"Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription."
Zhang Y. , Feng X.H. , Derynck R.
Nature394:909-913(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A COMPONENT OF THE SMAD3/SMAD4/JUN/FOS COMPLEX;INTERACTION WITH SMAD3
14.

"SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."
Rao S. , Matsumura A. , Yoon J. , Simon M.C.
J. Biol. Chem.274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPIB
15.

"Role of the ATFa/JNK2 complex in Jun activation."
De Graeve F. , Bahr A. , Sabapathy K.T. , Hauss C. , Wagner E.F. , Kedinger C. , Chatton B.
Oncogene18:3491-3500(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF7;MUTAGENESIS OF SER-63 AND SER-73
16.

"Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity."
Qing J. , Zhang Y. , Derynck R.
J. Biol. Chem.275:38802-38812(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAD3 IN THE SMAD3/SMAD4/JUN/FOS COMPLEX;DNA-BINDING;FUNCTION;MUTAGENESIS OF ARG-272
17.

"A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300."
Vries R.G. , Prudenziati M. , Zwartjes C. , Verlaan M. , Kalkhoven E. , Zantema A.
EMBO J.20:6095-6103(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-271 BY EP300
18.

"Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
Bower K.E. , Zeller R.W. , Wachsman W. , Martinez T. , McGuire K.L.
J. Biol. Chem.277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BATF3
19.

"Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
Bower K.E. , Fritz J.M. , McGuire K.L.
Oncogene23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BATF3
20.

"Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation."
Lan H.-C. , Li H.-J. , Lin G. , Lai P.-Y. , Chung B.-C.
Mol. Cell. Biol.27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION BY HIPK3
21.

"Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription."
Hung J.J. , Wang Y.T. , Chang W.C.
Mol. Cell. Biol.26:1770-1785(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SP1
22.

"Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells."
Wang L. , Dai W. , Lu L.
J. Biol. Chem.282:32121-32127(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-63 AND SER-73
23.

"Activation of Polo-like kinase 3 by hypoxic stresses."
Wang L. , Gao J. , Dai W. , Lu L.
J. Biol. Chem.283:25928-25935(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-63 AND SER-73
24.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-63; THR-239 AND SER-243;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
25.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-243;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
27.

"Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation."
Davies C.C. , Chakraborty A. , Cipriani F. , Haigh K. , Haigh J.J. , Behrens A.
Nat. Cell Biol.12:963-972(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF187
28.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
29.

"P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation."
Li T. , Zhang J. , Zhu F. , Wen W. , Zykova T. , Li X. , Liu K. , Peng C. , Ma W. , Shi G. , Dong Z. , Bode A.M. , Dong Z.
Carcinogenesis32:659-666(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-2; THR-8; THR-89; THR-93 AND THR-286;MUTAGENESIS OF THR-2; THR-8; THR-89; THR-93 AND THR-286
30.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-63;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
31.

"DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells."
Taira N. , Mimoto R. , Kurata M. , Yamaguchi T. , Kitagawa M. , Miki Y. , Yoshida K.
J. Clin. Invest.122:859-872(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-243;MUTAGENESIS OF SER-243
32.

"Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation."
Davies C.C. , Chakraborty A. , Diefenbacher M.E. , Skehel M. , Behrens A.
EMBO J.32:1556-1567(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF187
33.

"Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA."
Glover J.N. , Harrison S.C.
Nature373:257-261(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 257-313 OF COMPLEX WITH FOS
34.

"High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer."
Junius F.K. , O'Donoghue S.I. , Nilges M. , Weiss A.S. , King G.F.
J. Biol. Chem.271:13663-13667(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 276-314

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