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Index > Protein center > JUN(Gene name) > Human
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  • JUN (Gene name),
  • Transcription factor AP-1 (Protein name ),  JUN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    JUN;
    Protein name:
    Transcription factor AP-1;
    Alternative:
    Proto-oncogene c-Jun;Activator protein 1(AP1);p39;V-jun avian sarcoma virus 17 oncogene homolog;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3.
    Function:
    Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    331
    Sequence:
    50:
    MTAKMETTFY | DDALNASFLP | SESGPYGYSN | PKILKQSMTL | NLADPVGSLK | 
    100:
    PHLRAKNSDL | LTSPDVGLLK | LASPELERLI | IQSSNGHITT | TPTPTQFLCP | 
    150:
    KNVTDEQEGF | AEGFVRALAE | LHSQNTLPSV | TSAAQPVNGA | GMVAPAVASV | 
    200:
    AGGSGSGGFS | ASLHSEPPVY | ANLSNFNPGA | LSSGGGAPSY | GAAGLAFPAQ | 
    250:
    PQQQQQPPHH | LPQQMPVQHP | RLQALKEEPQ | TVPEMPGETP | PLSPIDMESQ | 
    300:
    ERIKAERKRM | RNRIAASKCR | KRKLERIARL | EEKVKTLKAQ | NSELASTANM | 
    331:
    LREQVAQLKQ | KVMNHVNSGC | QLMLTQQLQT | F
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    MIM:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Transcription factor AP-1
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    ELISA Kit for Human Transcription factor AP-1
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    ELISA Kit for Human Transcription factor AP-1
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    E1292h
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    ELISA Kit for Human Transcription factor AP-1
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    E1292b
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    ELISA Kit for Human Transcription factor AP-1
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    ELISA Kit for Human Transcription factor AP-1
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    E1292p
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    CLIA Kit for Human Transcription factor AP-1
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    U1292c
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    CLIA Kit for Human Transcription factor AP-1
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    CLIA Kit for Human Transcription factor AP-1
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    U1292b
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    MSDS:
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    CLIA Kit for Human Transcription factor AP-1
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    U1292h
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    CLIA Kit for Human Transcription factor AP-1
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    CLIA Kit for Human Transcription factor AP-1
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    Packing:
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    Polyclonal Antibody for Human Transcription factor AP-1
    Polyclonal Antibody for Human Transcription factor AP-1
    Polyclonal Antibody for Human Transcription factor AP-1
    Cat.:
    P1292Rb-m
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    Packing:
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    Polyclonal Antibody for Human Transcription factor AP-1
    Polyclonal Antibody for Human Transcription factor AP-1
    Cat.:
    P1292Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Transcription factor AP-1
    Cat.:
    P1292Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Transcription factor AP-1
    Monoclonal Antibody for Human Transcription factor AP-1
    Monoclonal Antibody for Human Transcription factor AP-1
    Monoclonal Antibody for Human Transcription factor AP-1
    Monoclonal Antibody for Human Transcription factor AP-1
    Monoclonal Antibody for Human Transcription factor AP-1
    Protein for Human Transcription factor AP-1
    Protein for Human Transcription factor AP-1
    Protein for Human Transcription factor AP-1
    Protein for Human Transcription factor AP-1
    Protein for Human Transcription factor AP-1
    Protein for Human Transcription factor AP-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure and chromosomal localization of the functional intronless human JUN protooncogene."
      Hattori K. , Angel P. , le Beau M.M. , Karin M.
      Proc. Natl. Acad. Sci. U.S.A.85:9148-9152(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1."
      Bohmann D. , Bos T.J. , Admon A. , Nishimura T. , Vogt P.K. , Tjian R.
      Science238:1386-1392(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      NIEHS SNPs program
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: B-cell.
      tissue: Ovary.
      tissue: Testis.
      tissue: Uterus.
    8. 8.
      "Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity."
      Boyle W.J. , Smeal T. , Defize L.H. , Angel P. , Woodgett J.R. , Karin M. , Hunter T.
      Cell64:573-584(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-239; SER-243 AND SER-249 BY GSK3B
    9. 9.
      "c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif."
      Bannister A.J. , Gottlieb T.M. , Kouzarides T. , Jackson S.P.
      Nucleic Acids Res.21:1289-1295(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-249
    10. 10.
      "Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."
      Enslen H. , Tokumitsu H. , Stork P.J. , Davis R.J. , Soderling T.R.
      Proc. Natl. Acad. Sci. U.S.A.93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAMK4
    11. 11.
      "Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene."
      Kirstein M. , Sanz L. , Moscat J. , Diaz-Meco M.T. , Saus J.
      J. Biol. Chem.271:18231-18236(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TCF20
    12. 12.
      "A new group of conserved coactivators that increase the specificity of AP-1 transcription factors."
      Claret F.-X. , Hibi M. , Dhut S. , Toda T. , Karin M.
      Nature383:453-457(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS5
    13. 13.
      "Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription."
      Zhang Y. , Feng X.H. , Derynck R.
      Nature394:909-913(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A COMPONENT OF THE SMAD3/SMAD4/JUN/FOS COMPLEX;INTERACTION WITH SMAD3
    14. 14.
      "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1."
      Rao S. , Matsumura A. , Yoon J. , Simon M.C.
      J. Biol. Chem.274:11115-11124(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPIB
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF7;MUTAGENESIS OF SER-63 AND SER-73
    16. 16.
      "Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity."
      Qing J. , Zhang Y. , Derynck R.
      J. Biol. Chem.275:38802-38812(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAD3 IN THE SMAD3/SMAD4/JUN/FOS COMPLEX;DNA-BINDING;FUNCTION;MUTAGENESIS OF ARG-272
    17. 17.
      "A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300."
      Vries R.G. , Prudenziati M. , Zwartjes C. , Verlaan M. , Kalkhoven E. , Zantema A.
      EMBO J.20:6095-6103(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-271 BY EP300
    18. 18.
      "Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions."
      Bower K.E. , Zeller R.W. , Wachsman W. , Martinez T. , McGuire K.L.
      J. Biol. Chem.277:34967-34977(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BATF3
    19. 19.
      "Transcriptional repression of MMP-1 by p21SNFT and reduced in vitro invasiveness of hepatocarcinoma cells."
      Bower K.E. , Fritz J.M. , McGuire K.L.
      Oncogene23:8805-8814(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BATF3
    20. 20.
      "Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation."
      Lan H.-C. , Li H.-J. , Lin G. , Lai P.-Y. , Chung B.-C.
      Mol. Cell. Biol.27:2027-2036(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION BY HIPK3
    21. 21.
      "Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription."
      Hung J.J. , Wang Y.T. , Chang W.C.
      Mol. Cell. Biol.26:1770-1785(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SP1
    22. 22.
      "Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells."
      Wang L. , Dai W. , Lu L.
      J. Biol. Chem.282:32121-32127(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-63 AND SER-73
    23. 23.
      "Activation of Polo-like kinase 3 by hypoxic stresses."
      Wang L. , Gao J. , Dai W. , Lu L.
      J. Biol. Chem.283:25928-25935(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-63 AND SER-73
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-63; THR-239 AND SER-243;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    25. 25.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    26. 26.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-243;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    27. 27.
      "Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation."
      Davies C.C. , Chakraborty A. , Cipriani F. , Haigh K. , Haigh J.J. , Behrens A.
      Nat. Cell Biol.12:963-972(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF187
    28. 28.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    29. 29.
      "P21-activated protein kinase (PAK2)-mediated c-Jun phosphorylation at 5 threonine sites promotes cell transformation."
      Li T. , Zhang J. , Zhu F. , Wen W. , Zykova T. , Li X. , Liu K. , Peng C. , Ma W. , Shi G. , Dong Z. , Bode A.M. , Dong Z.
      Carcinogenesis32:659-666(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-2; THR-8; THR-89; THR-93 AND THR-286;MUTAGENESIS OF THR-2; THR-8; THR-89; THR-93 AND THR-286
    30. 30.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-63;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    31. 31.
      "DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells."
      Taira N. , Mimoto R. , Kurata M. , Yamaguchi T. , Kitagawa M. , Miki Y. , Yoshida K.
      J. Clin. Invest.122:859-872(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-243;MUTAGENESIS OF SER-243
    32. 32.
      "Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation."
      Davies C.C. , Chakraborty A. , Diefenbacher M.E. , Skehel M. , Behrens A.
      EMBO J.32:1556-1567(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF187
    33. 33.
      "Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA."
      Glover J.N. , Harrison S.C.
      Nature373:257-261(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 257-313 OF COMPLEX WITH FOS
    34. 34.
      "High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer."
      Junius F.K. , O'Donoghue S.I. , Nilges M. , Weiss A.S. , King G.F.
      J. Biol. Chem.271:13663-13667(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 276-314
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