Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.
Function:
Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-430;TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-430;TISSUE SPECIFICITY
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Cited for: FUNCTION;PHOSPHORYLATION AT SER-53;MUTAGENESIS OF SER-2; SER-7; SER-10; SER-15; SER-18; SER-23; SER-30; SER-31; SER-34; SER-42; SER-44; SER-47; SER-49; SER-51 AND SER-53
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Cited for: GLYCOSYLATION AT SER-30; SER-31 AND SER-49;MUTAGENESIS OF SER-30; SER-31 AND SER-49;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2
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Cited for: PHOSPHORYLATION;INTERACTION WITH YWHAE; YWHAH AND YWHAZ
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Cited for: FUNCTION;CLEAVAGE BY CASPASES;MUTAGENESIS OF SER-53 AND ASP-238
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Cited for: FUNCTION;INTERACTION WITH YWHAE AND YWHAZ;PHOSPHORYLATION AT SER-34;MUTAGENESIS OF SER-34 AND SER-53
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Cited for: FUNCTION;INTERACTION WITH MUTATED CFTR;SUBCELLULAR LOCATION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-53
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Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;INDUCTION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-34; SER-42; SER-60; THR-302 AND SER-399;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-131 AND LYS-426;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-15; SER-34; SER-42; SER-60; THR-65; SER-100; SER-177; SER-319; SER-399 AND THR-404;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: VARIANTS CIRRH ALA-103; LEU-128; GLN-261 AND ARG-340;VARIANT THR-230