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Index > Protein center > KRT19(Gene name) > Human
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  • KRT19 (Gene name),
  • Keratin, type I cytoskeletal 19 (Protein name ),  K1C19_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KRT19;
    Protein name:
    Keratin, type I cytoskeletal 19;
    Alternative:
    Keratin-19(K19);Cytokeratin-19(CK-19);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
    Function:
    Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    400
    Sequence:
    50:
    MTSYSYRQSS | ATSSFGGLGG | GSVRFGPGVA | FRAPSIHGGS | GGRGVSVSSA | 
    100:
    RFVSSSSSGA | YGGGYGGVLT | ASDGLLAGNE | KLTMQNLNDR | LASYLDKVRA | 
    150:
    LEAANGELEV | KIRDWYQKQG | PGPSRDYSHY | YTTIQDLRDK | ILGATIENSR | 
    200:
    IVLQIDNARL | AADDFRTKFE | TEQALRMSVE | ADINGLRRVL | DELTLARTDL | 
    250:
    EMQIEGLKEE | LAYLKKNHEE | EISTLRGQVG | GQVSVEVDSA | PGTDLAKILS | 
    300:
    DMRSQYEVMA | EQNRKDAEAW | FTSRTEELNR | EVAGHTEQLQ | MSRSEVTDLR | 
    350:
    RTLQGLEIEL | QSQLSMKAAL | EDTLAETEAR | FGAQLAHIQA | LISGIEAQLG | 
    400:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    Pfam:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Keratin, type I cytoskeletal 19
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    E1239h
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    ELISA Kit for Human Keratin, type I cytoskeletal 19
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    E1239m
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    ELISA Kit for Human Keratin, type I cytoskeletal 19
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    E1239c
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    ELISA Kit for Human Keratin, type I cytoskeletal 19
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    E1239r
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    ELISA Kit for Human Keratin, type I cytoskeletal 19
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    E1239b
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    CLIA Kit for Human Keratin, type I cytoskeletal 19
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    U1239m
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    CLIA Kit for Human Keratin, type I cytoskeletal 19
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    U1239h
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    CLIA Kit for Human Keratin, type I cytoskeletal 19
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    U1239b
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    CLIA Kit for Human Keratin, type I cytoskeletal 19
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    U1239r
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    CLIA Kit for Human Keratin, type I cytoskeletal 19
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    U1239c
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 19
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    P1239Rb-h
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 19
    Polyclonal Antibody for Human Keratin, type I cytoskeletal 19
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    P1239Rb-r
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    Polyclonal Antibody for Human Keratin, type I cytoskeletal 19
    Polyclonal Antibody for Human Keratin, type I cytoskeletal 19
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    P1239Rb-m
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    Monoclonal Antibody for Human Keratin, type I cytoskeletal 19
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    M1239b
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    40ug
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 19
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    M1239c
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    40ug
    Monoclonal Antibody for Human Keratin, type I cytoskeletal 19
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    M1239h
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    Monoclonal Antibody for Human Keratin, type I cytoskeletal 19
    Cat.:
    M1239m
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    Monoclonal Antibody for Human Keratin, type I cytoskeletal 19
    Cat.:
    M1239r
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    Packing:
    40ug
    Protein for Human Keratin, type I cytoskeletal 19
    Protein for Human Keratin, type I cytoskeletal 19
    Protein for Human Keratin, type I cytoskeletal 19
    Protein for Human Keratin, type I cytoskeletal 19
    Protein for Human Keratin, type I cytoskeletal 19

    R&D Technical Data

    12% SDS-PAGE analysis

             12% SDS-PAGE analysis

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    Linearity
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    References
    1. 1.
      "Sequence of cDNA coding for human keratin 19."
      Stasiak P.C. , Lane E.B.
      Nucleic Acids Res.15:10058-10058(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLY-60
      tissue: Placenta.
    2. 2.
      "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."
      Bader B.L. , Jahn L. , Franke W.W.
      Eur. J. Cell Biol.47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
    3. 3.
      "Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin."
      Eckert R.L.
      Proc. Natl. Acad. Sci. U.S.A.85:1114-1118(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-60
    4. 4.
      "Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins."
      Stasiak P.C. , Purkis P.E. , Leigh I.M. , Lane E.B.
      J. Invest. Dermatol.92:707-716(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;VARIANT GLY-60
      tissue: Placenta.
    5. 5.
      "Genomic organization and amplification of the human keratin 15 and 19 genes."
      Whittock N.V. , Eady R.A.J. , McGrath J.A.
      Biochem. Biophys. Res. Commun.267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-60
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-60
      tissue: Placenta.
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-60
      tissue: Mammary gland.
      tissue: Pancreas.
      tissue: Placenta.
    8. 9.
      "Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line."
      Kagaya M. , Kaneko S. , Ohno H. , Inamura K. , Kobayashi K.
      J. Hepatol.35:504-511(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9
      tissue: Peripheral blood leukocyte.
    9. 10.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-31; 151-158 AND 227-237
      tissue: Keratinocyte.
    10. 11.
      "Diversity of keratin 19 gene expressed in lymph nodes of breast cancer patients -- strategy to clear the discrepancy between histological findings and RT-PCR results in the detection of micrometastasis."
      Sato T. , Weerasinghe A. , Kuwano Y. , Kaneko T. , Ikeda T. , Nagai T. , Makino H. , Sano M. , Honma K. , Nemoto K. , Abo T. , Shima Y.
      Seibutsu Butsuri Kagaku44:201-204(2000)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-352
      tissue: Lymph node.
    11. 12.
      "Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization."
      Zhou X. , Liao J. , Hu L. , Feng L. , Omary M.B.
      J. Biol. Chem.274:12861-12866(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-35;MUTAGENESIS OF SER-10 AND SER-35
    12. 13.
      "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus."
      Shi J. , Sugrue S.P.
      J. Biol. Chem.275:14910-14915(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PNN
    13. 14.
      "Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19."
      Stone M.R. , O'Neill A. , Catino D. , Bloch R.J.
      Mol. Biol. Cell16:4280-4293(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DMD;TISSUE SPECIFICITY
    14. 15.
      "Characterization of in vivo keratin 19 phosphorylation on tyrosine-391."
      Zhou Q. , Snider N.T. , Liao J. , Li D.H. , Hong A. , Ku N.O. , Cartwright C.A. , Omary M.B.
      PLoS ONE5:E13538-E13538(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-391
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-60;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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