Kalrn ELISA Kit for Rat(Rattus norvegicus) | EIAab.comKalrn ELISA Kit for Rat(Rattus norvegicus)

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Kalrn (Gene name),

Kalirin (Protein name ), KALRN_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Kalrn(Duo;Hapip);

Protein name:

Kalirin;

Alternative:

PAM COOH-terminal interactor protein 10(P-CIP10);Huntingtin-associated protein-interacting protein;Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain;Protein Duo;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG.

Function:

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton Isoform 6 is largely associated with synaptosomal membranes and to punctate structures in cortical neurons. Isoforms 1 and 7 are expressed in neuronal cell bodies, isoform 7 is also found in neuronal processes.

Protein Attributes:

Sequence length:

2959

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2959:

IVNRVNQGT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P97924

Pfam:

PF13716

Pfam:

PF00041

UniGene:

Rn.87882

String:

P97924

KEGG:

rno:84009

Uniprot:

P97924

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ELISA Kit for Rat Kalirin

Cat.:

E14464h

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Manual:

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Packing:

96T

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ELISA Kit for Rat Kalirin

Cat.:

E14464m

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Manual:

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Packing:

96T

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ELISA Kit for Rat Kalirin

Cat.:

E14464r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Kalirin

Cat.:

U14464m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Kalirin

Cat.:

U14464h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Kalirin

Cat.:

U14464r

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Packing:

96T

Polyclonal Antibody for Rat Kalirin

Cat.:

P14464Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Kalirin

Cat.:

P14464Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Kalirin

Cat.:

P14464Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Kalirin

Protein for Rat Kalirin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Novel proteins that interact with the COOH-terminal cytosolic routing determinants of an integral membrane peptide-processing enzyme."
Alam M.R. , Caldwell B.D. , Johnson R.C. , Darlington D.N. , Mains R.E. , Eipper B.A.
J. Biol. Chem.271:28636-28640(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Hippocampus.
2.

"Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme."
Alam M.R. , Johnson R.C. , Darlington D.N. , Hand T.A. , Mains R.E. , Eipper B.A.
J. Biol. Chem.272:12667-12675(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);INTERACTION WITH PAM
tissue: Hippocampus.
3.

"An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction."
Penzes P. , Johnson R.C. , Alam M.R. , Kambampati V. , Mains R.E. , Eipper B.A.
J. Biol. Chem.275:6395-6403(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
4.

"Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site."
Johnson R.C. , Penzes P. , Eipper B.A. , Mains R.E.
J. Biol. Chem.275:19324-19333(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5 AND 7);ALTERNATIVE INITIATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.

"Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity."
Schiller M.R. , Blangy A. , Huang J. , Mains R.E. , Eipper B.A.
Exp. Cell Res.307:402-417(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8);FUNCTION
6.

"Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain."
Colomer V. , Engelender S. , Sharp A.H. , Duan K. , Cooper J.K. , Lanahan A. , Lyford G. , Worley P. , Ross C.A.
Hum. Mol. Genet.6:1519-1525(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 638-1216 (ISOFORM 4)
tissue: Brain cortex.
tissue: Hippocampus.
7.

"Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology."
Penzes P. , Johnson R.C. , Kambampati V. , Mains R.E. , Eipper B.A.
J. Neurosci.21:8426-8434(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;DEVELOPMENTAL STAGE
8.

"Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions."
Schiller M.R. , Chakrabarti K. , King G.F. , Schiller N.I. , Eipper B.A. , Maciejewski M.W.
J. Biol. Chem.281:18774-18786(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1617-1707;DOMAIN;INTERACTION WITH CRK1

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