PRKACA ELISA Kit for Human(Homo sapiens) | EIAab.comPRKACA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PRKACA(Gene name) > Human

PRKACA (Gene name),

cAMP-dependent protein kinase catalytic subunit alpha (Protein name ), KAPCA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PRKACA(PKACA);

Protein name:

cAMP-dependent protein kinase catalytic subunit alpha(PKA C-alpha);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2.

Function:

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Subcellular Location:

Cytoplasm Cell membrane Nucleus Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.

Protein Attributes:

Sequence length:

351

Sequence:

50:

100:

150:

200:

250:

300:

350:

351:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P17612

MIM:

601639

STRING:

9606.ENSP00000309591

UniGene:

Hs.631630

KEGG:

hsa:5566

Pfam:

PF00069

SMR:

P17612

Uniprot:

P17612

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ELISA Kit for Human PKA C-alpha

Cat.:

E1918h

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96T

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ELISA Kit for Human PKA C-alpha

Cat.:

E1918m

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96T

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ELISA Kit for Human PKA C-alpha

Cat.:

E1918r

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96T

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ELISA Kit for Human PKA C-alpha

Cat.:

E1918d

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96T

ELISA Kit for Human PKA C-alpha

Cat.:

E1918p

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96T

ELISA Kit for Human PKA C-alpha

Cat.:

E1918b

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Packing:

96T

CLIA Kit for Human PKA C-alpha

Cat.:

U1918m

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Packing:

96T

CLIA Kit for Human PKA C-alpha

Cat.:

U1918r

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96T

CLIA Kit for Human PKA C-alpha

Cat.:

U1918b

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Packing:

96T

CLIA Kit for Human PKA C-alpha

Cat.:

U1918d

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Packing:

96T

CLIA Kit for Human PKA C-alpha

Cat.:

U1918p

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human PKA C-alpha

Cat.:

U1918h

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Manual:

Looking for manual.

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96T

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Polyclonal Antibody for Human PKA C-alpha

Cat.:

P1918Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human PKA C-alpha

Cat.:

P1918Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PKA C-alpha

Cat.:

P1918Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human PKA C-alpha

Protein for Human PKA C-alpha

Cat.:

R1918h

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Packing:

1mg

Purity:

>90%

Protein for Human PKA C-alpha

Cat.:

R1918m

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human PKA C-alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha."
Maldonado F. , Hanks S.K.
Nucleic Acids Res.16:8189-8190(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Thalamus.
3.

SeattleSNPs variation discovery resource
Submitted (2006-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Eye.
tissue: Testis.
6.

"A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece."
Reinton N. , Orstavik S. , Haugen T.B. , Jahnsen T. , Tasken K. , Skalhegg B.S.
Biol. Reprod.63:607-611(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-189 (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative C-alpha mRNA expressed specifically in spermatogenic cells."
San Agustin J.T. , Wilkerson C.G. , Witman G.B.
Mol. Biol. Cell11:3031-3044(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-152 (ISOFORM 2)
tissue: Testis.
8.

"Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development."
Desseyn J.-L. , Burton K.A. , McKnight G.S.
Proc. Natl. Acad. Sci. U.S.A.97:6433-6438(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-39 (ISOFORM 2)
tissue: Testis.
9.

"Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1."
Moore M.J. , Kanter J.R. , Jones K.C. , Taylor S.S.
J. Biol. Chem.277:47878-47884(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOPHOSPHORYLATION;PHOSPHORYLATION AT THR-196;PHOSPHORYLATION AT THR-198 BY PDK1;MUTAGENESIS OF ARG-195; GLY-201 AND THR-202
10.

"Rab13 regulates PKA signaling during tight junction assembly."
Koehler K. , Louvard D. , Zahraoui A.
J. Cell Biol.165:175-180(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB13
11.

"DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit."
Guan H. , Hou S. , Ricciardi R.P.
J. Biol. Chem.280:9957-9962(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NFKB1 KINASE
12.

"Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells."
D'Souza T. , Agarwal R. , Morin P.J.
J. Biol. Chem.280:26233-26240(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CLDN3 KINASE
13.

"PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells."
Pasqualucci L. , Kitaura Y. , Gu H. , Dalla-Favera R.
Proc. Natl. Acad. Sci. U.S.A.103:395-400(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AICDA
14.

"Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6."
Zhang F. , Hu Y. , Huang P. , Toleman C.A. , Paterson A.J. , Kudlow J.E.
J. Biol. Chem.282:22460-22471(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROTEASOME REGULATION;FUNCTION AS PSMC5/RPT6 KINASE
15.

"Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release."
Xiao B. , Tian X. , Xie W. , Jones P.P. , Cai S. , Wang X. , Jiang D. , Kong H. , Zhang L. , Chen K. , Walsh M.P. , Cheng H. , Chen S.R.W.
J. Biol. Chem.282:30256-30264(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RYR2 KINASE
16.

"Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells."
Ichikawa T. , Horie-Inoue K. , Ikeda K. , Blumberg B. , Inoue S.
J. Mol. Endocrinol.39:239-247(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;ENZYME REGULATION
17.

"Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells."
Xu H. , Washington S. , Verderame M.F. , Manni A.
Breast Cancer Res. Treat.107:63-70(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS ALPHA-DIFLUOROMETHYLORNITHINE ANTAGONIST
18.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-49 AND SER-339;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif."
Shirakawa K. , Takaori-Kondo A. , Yokoyama M. , Izumi T. , Matsui M. , Io K. , Sato T. , Sato H. , Uchiyama T.
Nat. Struct. Mol. Biol.15:1184-1191(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH APOBEC3G
20.

"Allosteric cooperativity in protein kinase A."
Masterson L.R. , Mascioni A. , Traaseth N.J. , Taylor S.S. , Veglia G.
Proc. Natl. Acad. Sci. U.S.A.105:506-511(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;MUTAGENESIS OF TYR-205
21.

"Gravin dynamics regulates the subcellular distribution of PKA."
Yan X. , Walkiewicz M. , Carlson J. , Leiphon L. , Grove B.
Exp. Cell Res.315:1247-1259(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
22.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
24.

"Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex."
Gambaryan S. , Kobsar A. , Rukoyatkina N. , Herterich S. , Geiger J. , Smolenski A. , Lohmann S.M. , Walter U.
J. Biol. Chem.285:18352-18363(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PLATELETS;FUNCTION AS VASP KINASE;INTERACTION WITH NFKB1; NFKB2 AND NFKBIA
25.

"High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway."
Wang W. , Zhang X. , Zheng J. , Yang J.
Mol. Cell. Biochem.338:115-122(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION;ENZYME REGULATION
26.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"Protein kinase A activates and phosphorylates ROR?4 in vitro and takes part in ROR? activation by CaMK-IV."
Ermisch M. , Firla B. , Steinhilber D.
Biochem. Biophys. Res. Commun.408:442-446(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RORA KINASE
28.

"The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA."
Vetter M.M. , Zenn H.-M. , Mendez E. , van den Boom H. , Herberg F.W. , Skaalhegg B.S.
BMC Biochem.12:40-40(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS KINASE;TISSUE SPECIFICITY;INTERACTION WITH PRKAR1A/PKR1 AND PRKAR2A/PKR2
29.

"Control of PKA stability and signalling by the RING ligase praja2."
Lignitto L. , Carlucci A. , Sepe M. , Stefan E. , Cuomo O. , Nistico R. , Scorziello A. , Savoia C. , Garbi C. , Annunziato L. , Feliciello A.
Nat. Cell Biol.13:412-422(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
30.

"Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors."
Goh G. , Scholl U.I. , Healy J.M. , Choi M. , Prasad M.L. , Nelson-Williams C. , Kunstman J.W. , Kuntsman J.W. , Korah R. , Suttorp A.C. , Dietrich D. , Haase M. , Willenberg H.S. , Staalberg P. , Hellman P. , Akerstroem G. , Bjoerklund P. , Carling T. , more...
Nat. Genet.46:613-617(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PPNAD4;VARIANT PPNAD4 ARG-206;CHARACTERIZATION OF VARIANT PPNAD4 ARG-206
31.

"Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies."
Lin X. , Murray J.M. , Rico A.C. , Wang M.X. , Chu D.T. , Zhou Y. , Del Rosario M. , Kaufman S. , Ma S. , Fang E. , Crawford K. , Jefferson A.B.
Bioorg. Med. Chem. Lett.16:4163-4168(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 15-351;PHOSPHORYLATION AT THR-198 AND SER-339
32.

"Azole-based inhibitors of AKT/PKB for the treatment of cancer."
Zeng Q. , Allen J.G. , Bourbeau M.P. , Wang X. , Yao G. , Tadesse S. , Rider J.T. , Yuan C.C. , Hong F.-T. , Lee M.R. , Zhang S. , Lofgren J.A. , Freeman D.J. , Yang S. , Li C. , Tominey E. , Huang X. , Hoffman D. , more...
Bioorg. Med. Chem. Lett.20:1559-1564(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS);PHOSPHORYLATION AT THR-198 AND SER-339;ENZYME REGULATION
33.

"Design of selective, ATP-competitive inhibitors of Akt."
Freeman-Cook K.D. , Autry C. , Borzillo G. , Gordon D. , Barbacci-Tobin E. , Bernardo V. , Briere D. , Clark T. , Corbett M. , Jakubczak J. , Kakar S. , Knauth E. , Lippa B. , Luzzio M.J. , Mansour M. , Martinelli G. , Marx M. , Nelson K. , more...
J. Med. Chem.53:4615-4622(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS);PHOSPHORYLATION AT THR-198 AND SER-339;ENZYME REGULATION
34.

"Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions."
Pflug A. , Rogozina J. , Lavogina D. , Enkvist E. , Uri A. , Engh R.A. , Bossemeyer D.
J. Mol. Biol.403:66-77(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ADENOSINE ANALOG;PHOSPHORYLATION AT SER-11; THR-198 AND SER-339;ENZYME REGULATION
35.

"Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase."
Pflug A. , de Oliveira T.M. , Bossemeyer D. , Engh R.A.
Biochem. J.440:85-93(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH AURORA KINASE INHIBITORS;PHOSPHORYLATION AT SER-11; THR-198 AND SER-339;MUTAGENESIS OF LYS-48; LEU-96; MET-121; VAL-124; GLN-182 AND THR-184
36.

"Experimental active site mapping as a starting point to fragment-based lead discovery."
Behnen J. , Koester H. , Ritschel T. , Neudert G. , Heine A. , Klebe G.
Submitted (2010-07) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS);PHOSPHORYLATION AT THR-198 AND SER-339
37.

"Fragment based drug design on PKA."
Koester H. , Craan T. , Brass S. , Heine A. , Klebe G.
Submitted (2010-09) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS)
38.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-41; GLN-46 AND CYS-264
39.

"Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome."
Beuschlein F. , Fassnacht M. , Assie G. , Calebiro D. , Stratakis C.A. , Osswald A. , Ronchi C.L. , Wieland T. , Sbiera S. , Faucz F.R. , Schaak K. , Schmittfull A. , Schwarzmayr T. , Barreau O. , Vezzosi D. , Rizk-Rabin M. , Zabel U. , Szarek E. , more...
N. Engl. J. Med.370:1019-1028(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPNAD4 ARG-206;CHARACTERIZATION OF VARIANT PPNAD4 ARG-206
40.

"Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome."
Cao Y. , He M. , Gao Z. , Peng Y. , Li Y. , Li L. , Zhou W. , Li X. , Zhong X. , Lei Y. , Su T. , Wang H. , Jiang Y. , Yang L. , Wei W. , Yang X. , Jiang X. , Liu L. , more...
Science344:913-917(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPNAD4 ARG-206;CHARACTERIZATION OF VARIANT PPNAD4 ARG-206
41.

"Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome."
Sato Y. , Maekawa S. , Ishii R. , Sanada M. , Morikawa T. , Shiraishi Y. , Yoshida K. , Nagata Y. , Sato-Otsubo A. , Yoshizato T. , Suzuki H. , Shiozawa Y. , Kataoka K. , Kon A. , Aoki K. , Chiba K. , Tanaka H. , Kume H. , more...
Science344:917-920(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPNAD4 ARG-206;CHARACTERIZATION OF VARIANT PPNAD4 ARG-206

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