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Index > Protein center > Prkacb(Gene name) > Mouse
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  • Prkacb (Gene name),
  • cAMP-dependent protein kinase catalytic subunit beta (Protein name ),  KAPCB_MOUSE from NCBI database.
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  • Gene name:
    Prkacb(Pkacb);
    Protein name:
    cAMP-dependent protein kinase catalytic subunit beta(PKA C-beta);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2.
    Function:
    Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
    Subcellular Location:
    Cytoplasm Cell membrane Nucleus Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm.
    Protein Attributes:
    Sequence length:
    351
    Sequence:
    50:
    MGNTAIAKKG | SEVESVKEFL | AKAKEDFLRK | WENPPPSNAG | LEDFERKKTL | 
    100:
    GTGSFGRVML | VKHKATEQYY | AMKILDKQKV | VKLKQIEHTL | NEKRILQAVE | 
    150:
    FPFLVRLEYS | FKDNSNLYMV | MEYVPGGEMF | SHLRRIGRFS | EPHARFYAAQ | 
    200:
    IVLTFEYLHS | LDLIYRDLKP | ENLLIDHQGY | IQVTDFGFAK | RVKGRTWTLC | 
    250:
    GTPEYLAPEI | ILSKGYNKAV | DWWALGVLIY | EMAAGYPPFF | ADQPIQIYEK | 
    300:
    IVSGKVRFPS | HFSSDLKDLL | RNLLQVDLTK | RFGNLKNGVS | DIKTHKWFAT | 
    350:
    TDWIAIYQRK | VEAPFIPKFR | GSGDTSNFDD | YEEEEIRVSI | TEKCGKEFCE | 
    351:
    F
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PKA C-beta
    Cat.:
    E1987h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse PKA C-beta
    Cat.:
    E1987m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse PKA C-beta
    Cat.:
    E1987r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse PKA C-beta
    Cat.:
    E1987b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse PKA C-beta
    Cat.:
    E1987p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PKA C-beta
    Cat.:
    U1987b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PKA C-beta
    Cat.:
    U1987h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PKA C-beta
    Cat.:
    U1987p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PKA C-beta
    Cat.:
    U1987m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PKA C-beta
    Cat.:
    U1987r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse PKA C-beta
    Cat.:
    P1987Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PKA C-beta
    Polyclonal Antibody for Mouse PKA C-beta
    Cat.:
    P1987Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PKA C-beta
    Cat.:
    P1987Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PKA C-beta
    Monoclonal Antibody for Mouse PKA C-beta
    Monoclonal Antibody for Mouse PKA C-beta
    Monoclonal Antibody for Mouse PKA C-beta
    Monoclonal Antibody for Mouse PKA C-beta
    Monoclonal Antibody for Mouse PKA C-beta
    Protein for Mouse PKA C-beta
    Protein for Mouse PKA C-beta
    Protein for Mouse PKA C-beta
    Cat.:
    R1987h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse PKA C-beta
    Cat.:
    R1987m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Mouse PKA C-beta

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase."
      Uhler M.D. , Chrivia J.C. , McKnight G.S.
      J. Biol. Chem.261:15360-15363(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4)
      strain: C57BL/6J.
      tissue: Adrenal gland.
      tissue: Head.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Characterization of genomic clones coding for the C alpha and C beta subunits of mouse cAMP-dependent protein kinase."
      Chrivia J.C. , Uhler M.D. , McKnight G.S.
      J. Biol. Chem.263:5739-5744(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15 (ISOFORM 1)
    5. 5.
      "Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase."
      Guthrie C.R. , Skalhegg B.S. , McKnight G.S.
      J. Biol. Chem.272:29560-29565(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7 (ISOFORM 2);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8 (ISOFORM 3);FUNCTION;MYRISTOYLATION AT GLY-2;TISSUE SPECIFICITY
    6. 6.
      "A collection of cDNA clones with specific expression patterns in mouse brain."
      Kato K.
      Eur. J. Neurosci.2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 281-351
      strain: BALB/c.
      tissue: Brain.
    7. 7.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-69;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
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