Gene name:
Camk2b (Camk2d) ;
Protein name:
Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta;CaMK-II subunit beta) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1, CAMK2N2 and MPDZ.
Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates to the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates to the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Subcellular Location:
Cytoplasm
cytoskeleton
Cytoplasm
cytoskeleton
centrosome
Sarcoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side
Protein Attributes:
50:
MATTVTCTRF | TDEYQLYEDI | GKGAFSVVRR | CVKLCTGHEY | AAKIINTKKL |
100:
SARDHQKLER | EARICRLLKH | SNIVRLHDSI | SEEGFHYLVF | DLVTGGELFE |
150:
DIVAREYYSE | ADASHCIQQI | LEAVLHCHQM | GVVHRDLKPE | NLLLASKCKG |
200:
AAVKLADFGL | AIEVQGDQQA | WFGFAGTPGY | LSPEVLRKEA | YGKPVDIWAC |
250:
GVILYILLVG | YPPFWDEDQH | KLYQQIKAGA | YDFPSPEWDT | VTPEAKNLIN |
300:
QMLTINPAKR | ITAHEALKHP | WVCQRSTVAS | MMHRQETVEC | LKKFNARRKL |
350:
KGAILTTMLA | TRNFSVGRQT | TAPATMSTAA | SGTTMGLVEQ | AKSLLNKKAD |
400:
GVKPQTNSTK | NSSAITSPKG | SLPPAALEPQ | TTVIHNPVDG | IKESSDSTNT |
450:
TIEDEDAKAR | KQEIIKTTEQ | LIEAVNNGDF | EAYAKICDPG | LTSFEPEALG |
500:
NLVEGMDFHR | FYFENLLAKN | SKPIHTTILN | PHVHVIGEDA | ACIAYIRLTQ |
542:
YIDGQGRPRT | SQSEETRVWH | RRDGKWQNVH | FHCSGAPVAP | LQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Mouse
Human
ELISA Kit for Mouse CaM kinase II subunit beta
ELISA Kit for Mouse CaM kinase II subunit beta
ELISA Kit for Mouse CaM kinase II subunit beta
ELISA Kit for Mouse CaM kinase II subunit beta
CLIA Kit for Mouse CaM kinase II subunit beta
CLIA Kit for Mouse CaM kinase II subunit beta
CLIA Kit for Mouse CaM kinase II subunit beta
CLIA Kit for Mouse CaM kinase II subunit beta
Polyclonal Antibody for Mouse CaM kinase II subunit beta
Polyclonal Antibody for Mouse CaM kinase II subunit beta
Polyclonal Antibody for Mouse CaM kinase II subunit beta
Polyclonal Antibody for Mouse CaM kinase II subunit beta
Monoclonal Antibody for Mouse CaM kinase II subunit beta
Monoclonal Antibody for Mouse CaM kinase II subunit beta
Monoclonal Antibody for Mouse CaM kinase II subunit beta
Monoclonal Antibody for Mouse CaM kinase II subunit beta
Protein for Mouse CaM kinase II subunit beta
Protein for Mouse CaM kinase II subunit beta
Protein for Mouse CaM kinase II subunit beta
Protein for Mouse CaM kinase II subunit beta
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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BALB/c .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE;MUTAGENESIS OF ALA-303