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Index > Protein center > Camk2b(Gene name) > Mouse
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  • Camk2b (Gene name),
  • Calcium/calmodulin-dependent protein kinase type II subunit beta (Protein name ),  KCC2B_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Camk2b(Camk2d);
    Protein name:
    Calcium/calmodulin-dependent protein kinase type II subunit beta(CaM kinase II subunit beta;CaMK-II subunit beta);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1, CAMK2N2 and MPDZ.
    Function:
    Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates to the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates to the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
    Subcellular Location:
    Cytoplasm cytoskeleton Cytoplasm cytoskeleton centrosome Sarcoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side
    Protein Attributes:
    Sequence length:
    542
    Sequence:
    50:
    MATTVTCTRF | TDEYQLYEDI | GKGAFSVVRR | CVKLCTGHEY | AAKIINTKKL | 
    100:
    SARDHQKLER | EARICRLLKH | SNIVRLHDSI | SEEGFHYLVF | DLVTGGELFE | 
    150:
    DIVAREYYSE | ADASHCIQQI | LEAVLHCHQM | GVVHRDLKPE | NLLLASKCKG | 
    200:
    AAVKLADFGL | AIEVQGDQQA | WFGFAGTPGY | LSPEVLRKEA | YGKPVDIWAC | 
    250:
    GVILYILLVG | YPPFWDEDQH | KLYQQIKAGA | YDFPSPEWDT | VTPEAKNLIN | 
    300:
    QMLTINPAKR | ITAHEALKHP | WVCQRSTVAS | MMHRQETVEC | LKKFNARRKL | 
    350:
    KGAILTTMLA | TRNFSVGRQT | TAPATMSTAA | SGTTMGLVEQ | AKSLLNKKAD | 
    400:
    GVKPQTNSTK | NSSAITSPKG | SLPPAALEPQ | TTVIHNPVDG | IKESSDSTNT | 
    450:
    TIEDEDAKAR | KQEIIKTTEQ | LIEAVNNGDF | EAYAKICDPG | LTSFEPEALG | 
    500:
    NLVEGMDFHR | FYFENLLAKN | SKPIHTTILN | PHVHVIGEDA | ACIAYIRLTQ | 
    542:
    YIDGQGRPRT | SQSEETRVWH | RRDGKWQNVH | FHCSGAPVAP | LQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse CaM kinase II subunit beta
    ELISA Kit for Mouse CaM kinase II subunit beta
    ELISA Kit for Mouse CaM kinase II subunit beta
    ELISA Kit for Mouse CaM kinase II subunit beta
    CLIA Kit for Mouse CaM kinase II subunit beta
    CLIA Kit for Mouse CaM kinase II subunit beta
    CLIA Kit for Mouse CaM kinase II subunit beta
    CLIA Kit for Mouse CaM kinase II subunit beta
    Polyclonal Antibody for Mouse CaM kinase II subunit beta
    Polyclonal Antibody for Mouse CaM kinase II subunit beta
    Polyclonal Antibody for Mouse CaM kinase II subunit beta
    Polyclonal Antibody for Mouse CaM kinase II subunit beta
    Monoclonal Antibody for Mouse CaM kinase II subunit beta
    Monoclonal Antibody for Mouse CaM kinase II subunit beta
    Monoclonal Antibody for Mouse CaM kinase II subunit beta
    Monoclonal Antibody for Mouse CaM kinase II subunit beta
    Protein for Mouse CaM kinase II subunit beta
    Protein for Mouse CaM kinase II subunit beta
    Protein for Mouse CaM kinase II subunit beta
    Protein for Mouse CaM kinase II subunit beta

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure, expression, and chromosome location of the gene for the beta subunit of brain-specific Ca2+/calmodulin-dependent protein kinase II identified by transgene integration in an embryonic lethal mouse mutant."
      Karls U. , Mueller U. , Gilbert D.J. , Copeland N.G. , Jenkins N.A. , Harbers K.
      Mol. Cell. Biol.12:3644-3652(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 136-147;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    5. 5.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    6. 6.
      "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P. , Tweedie-Cullen R. , Livingstone-Zatchej M. , Weinandy F. , Waidelich M. , Longo D. , Gehrig P. , Potthast F. , Rutishauser D. , Gerrits B. , Panse C. , Schlapbach R. , Mansuy I.M.
      Mol. Cell. Proteomics6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain cortex.
    7. 7.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-17;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    8. 8.
      "{beta}CaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting {alpha}CaMKII to synapses."
      Borgesius N.Z. , van Woerden G.M. , Buitendijk G.H. , Keijzer N. , Jaarsma D. , Hoogenraad C.C. , Elgersma Y.
      J. Neurosci.31:10141-10148(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;MUTAGENESIS OF ALA-303
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