Camk4 ELISA Kit for Mouse(Mus musculus) | EIAab.comCamk4 ELISA Kit for Mouse(Mus musculus)

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Camk4 (Gene name),

Calcium/calmodulin-dependent protein kinase type IV (Protein name ), KCC4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Camk4;

Protein name:

Calcium/calmodulin-dependent protein kinase type IV(CaMK IV);

Alternative:

CaM kinase-GR;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.

Function:

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteolclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphrylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). May be involved in spermatogenesis.

Subcellular Location:

Cytoplasm Nucleus Localized in hippocampal neuron nuclei (By similarity). In spermatids, associated with chromatin and nuclear matrix.

Protein Attributes:

Sequence length:

469

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

469:

EAPDAGLGVP | QQDAIQPEY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P08414

UniGene:

Mm.222329

Pfam:

PF00069

String:

P08414

Uniprot:

P08414

FOR

ELISA Kit for Mouse CaMK IV

CLIA Kit for Mouse CaMK IV

Polyclonal Antibody for Mouse CaMK IV

Monoclonal Antibody for Mouse CaMK IV

Protein for Mouse CaMK IV

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene."
Jones D.A. , Glod J. , Wilson-Shaw D. , Hahn W.E. , Sikela J.M.
FEBS Lett.289:105-109(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Brain.
2.

"Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV."
Sikela J.M. , Law M.L. , Kao F.-T. , Hartz J.A. , Wei Q. , Hahn W.E.
Genomics4:21-27(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 240-469
3.

"Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein."
Sikela J.M. , Hahn W.E.
Proc. Natl. Acad. Sci. U.S.A.84:3038-3042(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 315-469
tissue: Brain.
4.

"Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation."
Enslen H. , Sun P. , Brickey D. , Soderling S.H. , Klamo E. , Soderling T.R.
J. Biol. Chem.269:15520-15527(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CREB1
5.

"CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV."
Chawla S. , Hardingham G.E. , Quinn D.R. , Bading H.
Science281:1505-1509(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CREBBP
6.

"Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4."
Wu J.Y. , Ribar T.J. , Cummings D.E. , Burton K.A. , McKnight G.S. , Means A.R.
Nat. Genet.25:448-452(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PRM2;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
7.

"An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory."
Kang H. , Sun L.D. , Atkins C.M. , Soderling T.R. , Wilson M.A. , Tonegawa S.
Cell106:771-783(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Regulation of mitochondrial biogenesis in skeletal muscle by CaMK."
Wu H. , Kanatous S.B. , Thurmond F.A. , Gallardo T. , Isotani E. , Bassel-Duby R. , Williams R.S.
Science296:349-352(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
9.

"Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging."
Fukushima H. , Maeda R. , Suzuki R. , Suzuki A. , Nomoto M. , Toyoda H. , Wu L.J. , Xu H. , Zhao M.G. , Ueda K. , Kitamoto A. , Mamiya N. , Yoshida T. , Homma S. , Masushige S. , Zhuo M. , Kida S.
J. Neurosci.28:9910-9919(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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