KCNMA1(KCNMA);

Calcium-activated potassium channel subunit alpha-1;

bSlo;BKCA alpha;BK channel;K(VCA)alpha;Calcium-activated potassium channel, subfamily M subunit alpha-1;Maxi K channel(MaxiK);KCa1.1;Slo1;Slo-alpha;Slowpoke homolog(Slo homolog);

Bovine (Bos taurus). 

Homotetramer; which constitutes the calcium-activated potassium channel. Interacts with beta subunits KCNMB1, KCNMB2, KCNMB3 and KCNMB4. Beta subunits are accessory, and modulate its activity. Interacts with LRRC26.

Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Membrane Multi-pass membrane protein

1166

N/A

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PF03493

bta:282573

Bt.106645

Bt.546

Q28204