Protein name:
Calcium-activated potassium channel subunit beta-4 ;
Alternative:
Calcium-activated potassium channel, subfamily M subunit beta-4 ;BK channel subunit beta-4 (BKbeta4) ;K(VCA)beta-4 ;Charybdotoxin receptor subunit beta-4 ;Slo-beta-4 ;Maxi K channel subunit beta-4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer.
Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MAKLRVSYEY | TEAEDKSIRL | GLFLIVSGIL | SLFIFGFCWL | SPALQDLQAT |
100:
AANCTVLSVQ | QIGEVFECTF | TCGTDCRGTS | QYPCVQVYVN | NSESNSRALL |
150:
HSDQHQLLTN | PKCSYIPPCK | RENQKNSESV | MNWQQYWKDE | IGSQPFTCYF |
200:
NQHQRPEDVL | LQRTHDEIAL | LHCFLWPVVA | FVVGVLIVVL | TICAKSLAVK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Mouse Calcium-activated potassium channel subunit beta-4
ELISA Kit for Mouse Calcium-activated potassium channel subunit beta-4
ELISA Kit for Mouse Calcium-activated potassium channel subunit beta-4
CLIA Kit for Mouse Calcium-activated potassium channel subunit beta-4
CLIA Kit for Mouse Calcium-activated potassium channel subunit beta-4
CLIA Kit for Mouse Calcium-activated potassium channel subunit beta-4
Polyclonal Antibody for Mouse Calcium-activated potassium channel subunit beta-4
Polyclonal Antibody for Mouse Calcium-activated potassium channel subunit beta-4
Polyclonal Antibody for Mouse Calcium-activated potassium channel subunit beta-4
Monoclonal Antibody for Mouse Calcium-activated potassium channel subunit beta-4
Monoclonal Antibody for Mouse Calcium-activated potassium channel subunit beta-4
Monoclonal Antibody for Mouse Calcium-activated potassium channel subunit beta-4
Protein for Mouse Calcium-activated potassium channel subunit beta-4
Protein for Mouse Calcium-activated potassium channel subunit beta-4
Protein for Mouse Calcium-activated potassium channel subunit beta-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels."
Weiger T.M.
,
Holmqvist M.H.
,
Levitan I.B.
,
Clark F.T.
,
Sprague S.
,
Huang W.-J.
,
Ge P.
,
Wang C.
,
Lawson D.
,
Jurman M.E.
,
Glucksmann M.A.
,
Silos-Santiago I.
,
DiStefano P.S.
,
Curtis R.
J. Neurosci.20:3563-3570(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH KCNMA1
strain :
BALB/c .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]