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Index > Protein center > Kcnn2(Gene name) > Mouse
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  • Kcnn2 (Gene name),
  • Small conductance calcium-activated potassium channel protein 2 (Protein name ),  KCNN2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Kcnn2(Sk2);
    Protein name:
    Small conductance calcium-activated potassium channel protein 2(SK2;SKCa 2;SKCa2);
    Alternative:
    KCa2.2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding.
    Function:
    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    574
    Sequence:
    50:
    MSSCRYNGGV | MRPLSNLSSS | RRNLQEMDSE | AQPLQPPASV | VGGGGGASSP | 
    100:
    SAAAAASSSA | PEIVVSKPEH | NNSNNLALYG | TGGGGSTGGG | GGGSGHGSSS | 
    150:
    GTKSSKKKNQ | NIGYKLGHRR | ALFEKRKRLS | DYALIFGMFG | IVVMVIETEL | 
    200:
    SWGAYDKASL | YSLALKCLIS | LSTIILLGLI | IVYHAREIQL | FMVDNGADDW | 
    250:
    RIAMTYERIF | FICLEILVCA | IHPIPGNYTF | TWTARLAFSY | APSTTTADVD | 
    300:
    IILSIPMFLR | LYLIARVMLL | HSKLFTDASS | RSIGALNKIN | FNTRFVMKTL | 
    350:
    MTICPGTVLL | VFSISLWIIA | AWTVRACERY | HDQQDVTSNF | LGAMWLISIT | 
    400:
    FLSIGYGDMV | PNTYCGKGVC | LLTGIMGAGC | TALVVAVVAR | KLELTKAEKH | 
    450:
    VHNFMMDTQL | TKRVKNAAAN | VLRETWLIYK | NTKLVKKIDH | AKVRKHQRKF | 
    500:
    LQAIHQLRSV | KMEQRKLNDQ | ANTLVDLAKT | QNIMYDMISD | LNERSEDFEK | 
    550:
    RIVTLETKLE | TLIGSIHALP | GLISQTIRQQ | QRDFIETQME | NYDKHVSYNA | 
    574:
    ERSRSSSRRR | RSSSTAPPTS | SESS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse SK2
    ELISA Kit for Mouse SK2
    ELISA Kit for Mouse SK2
    CLIA Kit for Mouse SK2
    CLIA Kit for Mouse SK2
    CLIA Kit for Mouse SK2
    Polyclonal Antibody for Mouse SK2
    Polyclonal Antibody for Mouse SK2
    Polyclonal Antibody for Mouse SK2
    Monoclonal Antibody for Mouse SK2
    Monoclonal Antibody for Mouse SK2
    Monoclonal Antibody for Mouse SK2
    Protein for Mouse SK2
    Protein for Mouse SK2
    Protein for Mouse SK2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Sympathetic ganglion.
      tissue: Testis.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors."
      Nie L. , Song H. , Chen M.F. , Chiamvimonvat N. , Beisel K.W. , Yamoah E.N. , Vazquez A.E.
      J. Neurophysiol.91:1536-1544(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 241-839;FUNCTION
      strain: C3H/HeJ.
      tissue: Cochlea.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 258-839
      tissue: Brain.
    6. 6.
      "Molecular properties of small-conductance Ca2+-activated K+ channels expressed in murine colonic smooth muscle."
      Ro S. , Hatton W.J. , Koh S.D. , Horowitz B.
      Am. J. Physiol.281:G964-G973(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-839;FUNCTION;TISSUE SPECIFICITY
      strain: BALB/c.
      tissue: Colon.
    7. 7.
      "Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts."
      Xu Y. , Tuteja D. , Zhang Z. , Xu D. , Zhang Y. , Rodriguez J. , Nie L. , Tuxson H.R. , Young J.N. , Glatter K.A. , Vazquez A.E. , Yamoah E.N. , Chiamvimonvat N.
      J. Biol. Chem.278:49085-49094(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-839;FUNCTION;TISSUE SPECIFICITY
      strain: CD-1.
      tissue: Heart.
    8. 8.
      "Differential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytes."
      Tuteja D. , Xu D. , Timofeyev V. , Lu L. , Sharma D. , Zhang Z. , Xu Y. , Nie L. , Vazquez A.E. , Young J.N. , Glatter K.A. , Chiamvimonvat N.
      Am. J. Physiol.289:H2714-H2723(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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