Kidins220 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comKidins220 ELISA Kit for Rat(Rattus norvegicus)

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Kidins220 (Gene name),

Kinase D-interacting substrate of 220 kDa (Protein name ), KDIS_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Kidins220(Arms);

Protein name:

Kinase D-interacting substrate of 220 kDa;

Alternative:

Ankyrin repeat-rich membrane-spanning protein;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS. An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZ domains. Interacts with EPHA4 and PRKD1.

Function:

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1762

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1762:

STGFGEERES | IL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:116478

STRING:

10116.ENSRNOP00000062489

Pfam:

PF00023

UniGene:

Rn.21470

String:

Q9EQG6

Uniprot:

Q9EQG6

FOR

ELISA Kit for Rat Kinase D-interacting substrate of 220 kDa

CLIA Kit for Rat Kinase D-interacting substrate of 220 kDa

Polyclonal Antibody for Rat Kinase D-interacting substrate of 220 kDa

Monoclonal Antibody for Rat Kinase D-interacting substrate of 220 kDa

Protein for Rat Kinase D-interacting substrate of 220 kDa

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D."
Iglesias T. , Cabrera-Poch N. , Mitchell M.P. , Naven T.J.P. , Rozengurt E. , Schiavo G.
J. Biol. Chem.275:40048-40056(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;PHOSPHORYLATION AT SER-918;MUTAGENESIS OF SER-918;SUBCELLULAR LOCATION;INTERACTION WITH PRKD1
2.

"An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors."
Kong H. , Boulter J. , Weber J.L. , Lai C. , Chao M.V.
J. Neurosci.21:176-185(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH NGFR AND NTRK1;PHOSPHORYLATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: Sprague-Dawley.
3.

"A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein."
Arevalo J.C. , Yano H. , Teng K.K. , Chao M.V.
EMBO J.23:2358-2368(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;DOMAIN;INTERACTION WITH NTRK1; NTRK2; NTRK3 AND CRKL
4.

"Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein."
Chang M.-S. , Arevalo J.C. , Chao M.V.
J. Neurosci. Res.78:186-192(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NTRK1 AND NGFR
5.

"Alpha-syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner."
Luo S. , Chen Y. , Lai K.-O. , Arevalo J.C. , Froehner S.C. , Adams M.E. , Chao M.V. , Ip N.Y.
J. Cell Biol.169:813-824(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SNTA1; SNTB2 AND EPHA4;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;PHOSPHORYLATION;MUTAGENESIS OF SER-1760
6.

"Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth."
Hisata S. , Sakisaka T. , Baba T. , Yamada T. , Aoki K. , Matsuda M. , Takai Y.
J. Cell Biol.178:843-860(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH MAGI2; RAPGEF2 AND NTRK1;INTERACTION WITH RAPGEF2 AND MAGI2;SUBCELLULAR LOCATION

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