Gene name:
KHDRBS2 (SLM1) ;
Protein name:
KH domain-containing, RNA-binding, signal transduction-associated protein 2 ;
Alternative:
Sam68-like mammalian protein 1 (SLM-1;hSLM-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Self-associates to form homooligomers. Interacts with SAFB, SFRS9 and YTHDC1. Found in a complex with KHDRBS1, KHDRBS2 and KHDRBS3. Interacts with the SH3 domains of FYN and PLCG1. Interacts with the SH2 domains of FYN, GRAP2, PLCG1 and RASA1 (By similarity). Interacts with RBMX.
Function:
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MEEEKYLPEL | MAEKDSLDPS | FVHASRLLAE | EIEKFQGSDG | KKEDEEKKYL |
100:
DVISNKNIKL | SERVLIPVKQ | YPKFNFVGKL | LGPRGNSLKR | LQEETGAKMS |
150:
ILGKGSMRDK | AKEEELRKSG | EAKYAHLSDE | LHVLIEVFAP | PGEAYSRMSH |
200:
ALEEIKKFLV | PDYNDEIRQE | QLRELSYLNG | SEDSGRGRGI | RGRGIRIAPT |
250:
APSRGRGGAI | PPPPPPGRGV | LTPRGSTVTR | GALPVPPVAR | GVPTPRARGA |
300:
PTVPGYRAPP | PPAHEAYEEY | GYDDGYGGEY | DDQTYETYDN | SYATQTQSVP |
349:
EYYDYGHGVS | EDAYDSYAPE | EWATTRSSLK | APPQRSARGG | YREHPYGRY
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
ELISA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
ELISA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
CLIA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
CLIA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
CLIA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Polyclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Polyclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Polyclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Monoclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Monoclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Monoclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Protein for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Protein for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
Protein for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Fetal brain .
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Spleen .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : METHYLATION
7.
"Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA."
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J. Biol. Chem.284:14303-14315(2009)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RBMX