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Index > Protein center > KHDRBS2(Gene name) > Human
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  • KHDRBS2 (Gene name),
  • KH domain-containing, RNA-binding, signal transduction-associated protein 2 (Protein name ),  KHDR2_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    KHDRBS2(SLM1);
    Protein name:
    KH domain-containing, RNA-binding, signal transduction-associated protein 2;
    Alternative:
    Sam68-like mammalian protein 1(SLM-1;hSLM-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Self-associates to form homooligomers. Interacts with SAFB, SFRS9 and YTHDC1. Found in a complex with KHDRBS1, KHDRBS2 and KHDRBS3. Interacts with the SH3 domains of FYN and PLCG1. Interacts with the SH2 domains of FYN, GRAP2, PLCG1 and RASA1 (By similarity). Interacts with RBMX.
    Function:
    RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    349
    Sequence:
    50:
    MEEEKYLPEL | MAEKDSLDPS | FVHASRLLAE | EIEKFQGSDG | KKEDEEKKYL | 
    100:
    DVISNKNIKL | SERVLIPVKQ | YPKFNFVGKL | LGPRGNSLKR | LQEETGAKMS | 
    150:
    ILGKGSMRDK | AKEEELRKSG | EAKYAHLSDE | LHVLIEVFAP | PGEAYSRMSH | 
    200:
    ALEEIKKFLV | PDYNDEIRQE | QLRELSYLNG | SEDSGRGRGI | RGRGIRIAPT | 
    250:
    APSRGRGGAI | PPPPPPGRGV | LTPRGSTVTR | GALPVPPVAR | GVPTPRARGA | 
    300:
    PTVPGYRAPP | PPAHEAYEEY | GYDDGYGGEY | DDQTYETYDN | SYATQTQSVP | 
    349:
    EYYDYGHGVS | EDAYDSYAPE | EWATTRSSLK | APPQRSARGG | YREHPYGRY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    ELISA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    ELISA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    CLIA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    CLIA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    CLIA Kit for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Polyclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Polyclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Polyclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Monoclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Monoclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Monoclonal Antibody for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Protein for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Protein for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2
    Protein for Human KH domain-containing, RNA-binding, signal transduction-associated protein 2

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2."
      Wang L. , Xu J. , Zeng L. , Ye X. , Wu Q. , Dai J. , Ji C. , Gu S. , Zhao C. , Xie Y. , Mao Y.
      Mol. Biol. Rep.29:369-375(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Fetal brain.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Spleen.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1."
      Cote J. , Boisvert F.-M. , Boulanger M.-C. , Bedford M.T. , Richard S.
      Mol. Biol. Cell14:274-287(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION
    7. 7.
      "Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA."
      Heinrich B. , Zhang Z. , Raitskin O. , Hiller M. , Benderska N. , Hartmann A.M. , Bracco L. , Elliott D. , Ben-Ari S. , Soreq H. , Sperling J. , Sperling R. , Stamm S.
      J. Biol. Chem.284:14303-14315(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBMX
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