Protein name:
Kinesin-like protein KIF2C ;
Alternative:
Mitotic centromere-associated kinesin (MCAK) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends.
Function:
Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
Subcellular Location:
Cytoplasm
cytoskeleton
Nucleus
Chromosome
centromere
Chromosome
centromere
kinetochore
Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1. Centromeric localization requires the presence of BUB1 and SGOL2.
Protein Attributes:
50:
MESLHARLFP | GLSINIQRSN | GLIHPANIST | VNVEKSCVSV | EWIEGGTTKG |
100:
KEIDIDDVAA | INPELLQLLP | LRPKDSLPLQ | ENVTVPKQKR | KSVNSKIPAL |
150:
KEGLRSRSTR | MSTVSEVRIP | AQENEMEVEL | PVPTNSRKQF | AIPSHPRASC |
200:
STVTELPLLM | VSEEAEEQAH | STRSTSSANP | GNSVRRKSCI | VKEMEKMKNK |
250:
REEKRAQNSE | LRIKRAQEYD | SSFPNWEFAR | MIKEFRVTME | CSPLTVTDPI |
300:
EEHRICVCVR | KRPLNKQELA | KKEIDVISVP | SKCLLLVHEP | KLKVDLTKYL |
350:
ENQAFCFDFA | FDETASNEVV | YRFTARPLVQ | TIFEGGKATC | FAYGQTGSGK |
400:
THTMGGDLSG | KSQNASKGIY | AMASRDVFLL | KNQPRYRNLN | LEVYVTFFEI |
450:
YNGKVFDLLN | KKAKLRVLED | SRQQVQVVGL | QEYLVTCADD | VIKMINMGSA |
500:
CRTSGQTFAN | SNSSRSHACF | QILLRTKGRL | HGKFSLVDLA | GNERGADTSS |
550:
ADRQTRMEGA | EINKSLLALK | ECIRALGQNK | AHTPFRESKL | TQVLRDSFIG |
600:
ENSRTCMIAM | ISPGISSCEY | TLNTLRYADR | VKELSPHSGP | SGEQPVQMET |
650:
EVMEASSNGT | SLTGNEEEEL | SSQMSSFNEA | MTQIRELEER | ALEELREIIQ |
700:
QGPNWLELSE | MTDQPDYDLE | TFVNKAESAL | TQQAKQAKHF | SALREVIKAL |
721:
RLAMQLEEQA | SKQINSKKRH | Q
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Mouse Kinesin-like protein KIF2C
ELISA Kit for Mouse Kinesin-like protein KIF2C
ELISA Kit for Mouse Kinesin-like protein KIF2C
CLIA Kit for Mouse Kinesin-like protein KIF2C
CLIA Kit for Mouse Kinesin-like protein KIF2C
CLIA Kit for Mouse Kinesin-like protein KIF2C
Polyclonal Antibody for Mouse Kinesin-like protein KIF2C
Polyclonal Antibody for Mouse Kinesin-like protein KIF2C
Polyclonal Antibody for Mouse Kinesin-like protein KIF2C
Monoclonal Antibody for Mouse Kinesin-like protein KIF2C
Monoclonal Antibody for Mouse Kinesin-like protein KIF2C
Monoclonal Antibody for Mouse Kinesin-like protein KIF2C
Protein for Mouse Kinesin-like protein KIF2C
Protein for Mouse Kinesin-like protein KIF2C
Protein for Mouse Kinesin-like protein KIF2C
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 183-585 IN COMPLEX WITH ADP AND ATP ANALOG;FUNCTION;MUTAGENESIS OF LYS-293; VAL-294 AND ASP-295