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Index > Protein center > KIRREL(Gene name) > Human
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  • KIRREL (Gene name),
  • Kin of IRRE-like protein 1 (Protein name ),  KIRR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KIRREL(KIRREL1;NEPH1);
    Protein name:
    Kin of IRRE-like protein 1;
    Alternative:
    Nephrin-like protein 1;Kin of irregular chiasm-like protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains).
    Function:
    Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm.
    Protein Attributes:
    Sequence length:
    757
    Sequence:
    50:
    MLSLLVWILT | LSDTFSQGTQ | TRFSQEPADQ | TVVAGQRAVL | PCVLLNYSGI | 
    100:
    VQWTKDGLAL | GMGQGLKAWP | RYRVVGSADA | GQYNLEITDA | ELSDDASYEC | 
    150:
    QATEAALRSR | RAKLTVLIPP | EDTRIDGGPV | ILLQAGTPHN | LTCRAFNAKP | 
    200:
    AATIIWFRDG | TQQEGAVAST | ELLKDGKRET | TVSQLLINPT | DLDIGRVFTC | 
    250:
    RSMNEAIPSG | KETSIELDVH | HPPTVTLSIE | PQTVQEGERV | VFTCQATANP | 
    300:
    EILGYRWAKG | GFLIEDAHES | RYETNVDYSF | FTEPVSCEVH | NKVGSTNVST | 
    350:
    LVNVHFAPRI | VVDPKPTTTD | IGSDVTLTCV | WVGNPPLTLT | WTKKDSNMVL | 
    400:
    SNSNQLLLKS | VTQADAGTYT | CRAIVPRIGV | AEREVPLYVN | GPPIISSEAV | 
    450:
    QYAVRGDGGK | VECFIGSTPP | PDRIAWAWKE | NFLEVGTLER | YTVERTNSGS | 
    500:
    GVLSTLTINN | VMEADFQTHY | NCTAWNSFGP | GTAIIQLEER | EVLPVGIIAG | 
    550:
    ATIGASILLI | FFFIALVFFL | YRRRKGSRKD | VTLRKLDIKV | ETVNREPLTM | 
    600:
    HSDREDDTAS | VSTATRVMKA | IYSSFKDDVD | LKQDLRCDTI | DTREEYEMKD | 
    650:
    PTNGYYNVRA | HEDRPSSRAV | LYADYRAPGP | ARFDGRPSSR | LSHSSGYAQL | 
    700:
    NTYSRGPASD | YGPEPTPPGP | AAPAGTDTTS | QLSYENYEKF | NSHPFPGAAG | 
    750:
    YPTYRLGYPQ | APPSGLERTP | YEAYDPIGKY | ATATRFSYTS | QHSDYGQRFQ | 
    757:
    QRMQTHV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kin of IRRE-like protein 1
    Cat.:
    E2838m
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    Packing:
    96T
    ELISA Kit for Human Kin of IRRE-like protein 1
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    E2838h
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    ELISA Kit for Human Kin of IRRE-like protein 1
    Cat.:
    E2838r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Kin of IRRE-like protein 1
    Cat.:
    U2838m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kin of IRRE-like protein 1
    Cat.:
    U2838h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Kin of IRRE-like protein 1
    Cat.:
    U2838r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Kin of IRRE-like protein 1
    Cat.:
    P2838Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kin of IRRE-like protein 1
    Cat.:
    P2838Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kin of IRRE-like protein 1
    Cat.:
    P2838Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Kin of IRRE-like protein 1
    Monoclonal Antibody for Human Kin of IRRE-like protein 1
    Monoclonal Antibody for Human Kin of IRRE-like protein 1
    Protein for Human Kin of IRRE-like protein 1
    Protein for Human Kin of IRRE-like protein 1
    Protein for Human Kin of IRRE-like protein 1

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-606 (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Kidney.
    2. 2.
      Shan Y.X. , Huang C.Q. , Yu L.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 251-757 (ISOFORM 2)
      tissue: Ovary.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 199-757 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 303-757 (ISOFORM 1)
    7. 7.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-622; TYR-625 AND TYR-724;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    8. 8.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-297
      tissue: Liver.
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
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