KISS1 ELISA Kit for Human(Homo sapiens) | EIAab.comKISS1 ELISA Kit for Human(Homo sapiens)

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KISS1 (Gene name),

Metastasis-suppressor KiSS-1 (Protein name ), KISS1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KISS1(PP5098);

Protein name:

Metastasis-suppressor KiSS-1;

Alternative:

Kisspeptin-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

138

Sequence:

50:

100:

138:

VLVQREKDLP | NYNWNSFGLR | FGKREAAPGN | HGRSAGRG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:3814

MIM:

603286

String:

Q15726

UniGene:

Hs.95008

STRING:

9606.ENSP00000356162

Uniprot:

Q15726

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ELISA Kit for Human Metastasis-suppressor KiSS-1

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E2063r

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ELISA Kit for Human Metastasis-suppressor KiSS-1

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E2063h

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96T

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ELISA Kit for Human Metastasis-suppressor KiSS-1

Cat.:

E2063m

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96T

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CLIA Kit for Human Metastasis-suppressor KiSS-1

Cat.:

U2063r

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96T

CLIA Kit for Human Metastasis-suppressor KiSS-1

Cat.:

U2063h

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96T

CLIA Kit for Human Metastasis-suppressor KiSS-1

Cat.:

U2063m

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Packing:

96T

Polyclonal Antibody for Human Metastasis-suppressor KiSS-1

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P2063Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Metastasis-suppressor KiSS-1

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P2063Rb-m

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Polyclonal Antibody for Human Metastasis-suppressor KiSS-1

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P2063Rb-h

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Monoclonal Antibody for Human Metastasis-suppressor KiSS-1

Protein for Human Metastasis-suppressor KiSS-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"KiSS-1, a novel human malignant melanoma metastasis-suppressor gene."
Lee J.-H. , Miele M.E. , Hicks D.J. , Phillips K.K. , Trent J.M. , Weissman B.E. , Welch D.R.
J. Natl. Cancer Inst.88:1731-1737(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

Lee J.-H. , Miele M.E. , Hicks D.J. , Phillips K.K. , Trent J.M. , Weissman B.E. , Welch D.R.
J. Natl. Cancer Inst.89:1549-1549(1997)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1)."
West A. , Vojta P.J. , Welch D.R. , Weissman B.E.
Genomics54:145-148(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-81
4.

"Cloned KiSS-1 gene from human term placenta."
Qiao C. , Lin Q.D. , Xu W.X. , He Y. , Wang C.H.
Submitted (2002-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-81
tissue: Term placenta.
5.

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
7.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Skin.
9.

"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor."
Ohtaki T. , Shintani Y. , Honda S. , Matsumoto H. , Hori A. , Kanehashi K. , Terao Y. , Kumano S. , Takatsu Y. , Masuda Y. , Ishibashi Y. , Watanabe T. , Asada M. , Yamada T. , Suenaga M. , Kitada C. , Usuki S. , Kurokawa T. , more...
Nature411:613-617(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 68-88;AMIDATION AT PHE-121;FUNCTION;TISSUE SPECIFICITY
tissue: Placenta.
10.

"Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1."
Lee J.-H. , Welch D.R.
Cancer Res.57:2384-2387(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTION ON BREAST CARCINOMA
11.

"Identification of highly expressed genes in metastasis-suppressed chromosome 6/human malignant melanoma hybrid cells using subtractive hybridization and differential display."
Lee J.-H. , Welch D.R.
Int. J. Cancer71:1035-1044(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54."
Kotani M. , Detheux M. , Vandenbogaerde A. , Communi D. , Vanderwinden J.-M. , Le Poul E. , Brezillon S. , Tyldesley R. , Suarez-Huerta N. , Vandeput F. , Blanpain C. , Schiffmann S.N. , Vassart G. , Parmentier M.
J. Biol. Chem.276:34631-34636(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE FUNCTION
13.

"Metastin suppresses the motility and growth of CHO cells transfected with its receptor."
Hori A. , Honda S. , Asada M. , Ohtaki T. , Oda K. , Watanabe T. , Shintani Y. , Yamada T. , Suenaga M. , Kitada C. , Onda H. , Kurokawa T. , Nishimura O. , Fujino M.
Biochem. Biophys. Res. Commun.286:958-963(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CELL MOBILITY AND GROWTH INHIBITION
14.

"KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of IkappaBalpha-induced block of p65/p50 nuclear translocation."
Yan C. , Wang H. , Boyd D.D.
J. Biol. Chem.276:1164-1172(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REPRESSION OF MPP9 EXPRESSION
15.

"Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23."
Shirasaki F. , Takata M. , Hatta N. , Takehara K.
Cancer Res.61:7422-7425(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;DOWN-REGULATION DURING THE PROGRESSION OF MELANOMA
16.

"Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells."
Janneau J.-L. , Maldonado-Estrada J. , Tachdjian G. , Miran I. , Motte N. , Saulnier P. , Sabourin J.-C. , Cote J.-F. , Simon B. , Frydman R. , Chaouat G. , Bellet D.
J. Clin. Endocrinol. Metab.87:5336-5339(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;POSSIBLE INVOLVEMENT IN INVASION/MIGRATION OF TROPHOBLAST CELLS
17.

"Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells."
Ringel M.D. , Hardy E. , Bernet V.J. , Burch H.B. , Schuppert F. , Burman K.D. , Saji M.
J. Clin. Endocrinol. Metab.87:2399-2399(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN THYROID CANCER
18.

"Tumor suppressor role of KiSS-1 in bladder cancer: loss of KiSS-1 expression is associated with bladder cancer progression and clinical outcome."
Sanchez-Carbayo M. , Capodieci P. , Cordon-Cardo C.
Am. J. Pathol.162:609-617(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POTENTIAL TUMOR SUPPRESSION ROLE IN BLADDER CANCER
19.

"Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans."
Horikoshi Y. , Matsumoto H. , Takatsu Y. , Ohtaki T. , Kitada C. , Usuki S. , Fujino M.
J. Clin. Endocrinol. Metab.88:914-919(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE FUNCTION AS A PLACENTA-DERIVED HORMONE
20.

"Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."
Takino T. , Koshikawa N. , Miyamori H. , Tanaka M. , Sasaki T. , Okada Y. , Seiki M. , Sato H.
Oncogene22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY MMP2 AND MMP9;POSSIBLE USE AS AN ANTIMETASTATIC AGENT
21.

"Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma."
Ikeguchi M. , Hirooka Y. , Kaibara N.
J. Cancer Res. Clin. Oncol.129:531-535(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN HEPATOCELLULAR CARCINOMA
22.

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
23.

"Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma."
Ikeguchi M. , Yamaguchi K. , Kaibara N.
Clin. Cancer Res.10:1379-1383(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN ESOPHAGAL SQUAMOUS CELL CARCINOMA
24.

"Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts."
Bilban M. , Ghaffari-Tabrizi N. , Hintermann E. , Bauer S. , Molzer S. , Zoratti C. , Malli R. , Sharabi A. , Hiden U. , Graier W. , Knoefler M. , Andreae F. , Wagner O. , Quaranta V. , Desoye G.
J. Cell Sci.117:1319-1328(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INVOLVEMENT IN THROPHOBLAST MIGRATION AND INVASION
25.

"Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma."
Dhar D.K. , Naora H. , Kubota H. , Maruyama R. , Yoshimura H. , Tonomoto Y. , Tachibana M. , Ono T. , Otani H. , Nagasue N.
Int. J. Cancer111:868-872(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ROLE IN GASTRIC CANCER INVASION
26.

"Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat."
Matsui H. , Takatsu Y. , Kumano S. , Matsumoto H. , Ohtaki T.
Biochem. Biophys. Res. Commun.320:383-388(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ROLE IN GONADOPTROPIN RELEASE
27.

"Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis."
Thompson E.L. , Patterson M. , Murphy K.G. , Smith K.L. , Dhillo W.S. , Todd J.F. , Ghatei M.A. , Bloom S.R.
J. Neuroendocrinol.16:850-858(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN STIMULATION OF THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS
28.

"Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumor cells through a specific transcriptional program not shared by other G(q)-coupled receptors."
Becker J.A.J. , Mirjolet J.-F. , Bernard J. , Burgeon E. , Simons M.-J. , Vassart G. , Parmentier M. , Libert F.
Biochem. Biophys. Res. Commun.326:677-686(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF METASTASIS SUPPRESSOR PROPERTIES
29.

"Two novel missense mutations in G protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism."
Semple R.K. , Achermann J.C. , Ellery J. , Farooqi I.S. , Karet F.E. , Stanhope R.G. , O'rahilly S. , Aparicio S.A.
J. Clin. Endocrinol. Metab.90:1849-1855(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-20; ARG-36 AND ARG-81
30.

"Inactivating KISS1 mutation and hypogonadotropic hypogonadism."
Topaloglu A.K. , Tello J.A. , Kotan L.D. , Ozbek M.N. , Yilmaz M.B. , Erdogan S. , Gurbuz F. , Temiz F. , Millar R.P. , Yuksel B.
N. Engl. J. Med.366:629-635(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH13 LYS-115;CHARACTERIZATION OF VARIANT HH13 LYS-115

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