Protein name:
Mast/stem cell growth factor receptor Kit (SCFR) ;
Alternative:
Tyrosine-protein kinase Kit ;Proto-oncogene c-Kit ;
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. KIT promotes activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MEGAHLAWEL | AHAVLLLSLI | PAGGSVPHEE | SSLVVNKGEE | LRLKCNEEGP |
100:
VTWNFQNSDP | SAKTRISNEK | EWHTKNATIR | DIGRYECKSK | GSIVNSFYVF |
150:
VKDPNVLFLV | DSLIYGKEDS | DILLVCPLTD | PDVLNFTLRK | CDGKPLPKNM |
200:
TFIPNPQKGI | IIKNVQRSFK | GCYQCLAKHN | GVEKISEHIF | LNVRPVHKAL |
250:
PVITLSKSYE | LLKEGEEFEV | TCIITDVDSS | VKASWISYKS | AIVTSKSRNL |
300:
GDYGYERKLT | LNIRSVGVND | SGEFTCQAEN | PFGKTNATVT | LKALAKGFVR |
350:
LFATMNTTID | INAGQNGNLT | VEYEAYPKPK | EEVWMYMNET | LQNSSDHYVK |
400:
FKTVGNNSYT | SELHLTRLKG | TEGGIYTFFV | SNSDASSSVT | FNVYVKTKPE |
450:
ILTLDMLGND | ILQCVATGFP | APTIYWYFCP | GTEQRCLDSP | TISPMDVKVS |
500:
YTNSSVPSFE | RILVESTVNA | SMFKSTGTIC | CEASSNGDKS | SVFFNFAIKE |
550:
QIRTHTLFTP | LLIAFGVAAG | LMCIIVMILV | YIYLQKPKYE | VQWKVVEEIN |
600:
GNNYVYIDPT | QLPYDHKWEF | PRNRLSFGKT | LGAGAFGKVV | EATAYGLFKS |
650:
DAAMTVAVKM | LKPSAHLTER | EALMSELKVL | SYLGNHINIV | NLLGACTIGG |
700:
PTLVITEYCC | YGDLLNFLRR | KRDSFICPKH | EEHAEAAVYE | NLLHQAEPTA |
750:
DAVNEYMDMK | PGVSYAVPPK | ADKKRPVKSG | SYTDQDVTLS | MLEDDELALD |
800:
VEDLLSFSYQ | VAKGMSFLAS | KNCIHRDLAA | RNILLTHGRI | TKICDFGLAR |
850:
DIRNDSNYVV | KGNARLPVKW | MAPESIFNCV | YTFESDVWSY | GILLWELFSL |
900:
GSSPYPGMPV | DSKFYKMIKE | GYRMFSPECS | PPEMYDIMKS | CWDADPLQRP |
950:
TFKQIVQLIE | QQLSDNAPRV | YANFSTPPST | QGNATDHSVR | INSVGSSASS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Dog
Pig
Chicken
ELISA Kit for Chicken SCFR
ELISA Kit for Chicken SCFR
ELISA Kit for Chicken SCFR
ELISA Kit for Chicken SCFR
ELISA Kit for Chicken SCFR
ELISA Kit for Chicken SCFR
CLIA Kit for Chicken SCFR
CLIA Kit for Chicken SCFR
CLIA Kit for Chicken SCFR
CLIA Kit for Chicken SCFR
CLIA Kit for Chicken SCFR
CLIA Kit for Chicken SCFR
Polyclonal Antibody for Chicken SCFR
Polyclonal Antibody for Chicken SCFR
Polyclonal Antibody for Chicken SCFR
Polyclonal Antibody for Chicken SCFR
Polyclonal Antibody for Chicken SCFR
Polyclonal Antibody for Chicken SCFR
Monoclonal Antibody for Chicken SCFR
Monoclonal Antibody for Chicken SCFR
Monoclonal Antibody for Chicken SCFR
Monoclonal Antibody for Chicken SCFR
Monoclonal Antibody for Chicken SCFR
Monoclonal Antibody for Chicken SCFR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
White leghorn .
tissue :
Brain .