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Index > Protein center > Klf4(Gene name) > Mouse
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  • Klf4 (Gene name),
  • Krueppel-like factor 4 (Protein name ),  KLF4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Klf4(Ezf;Gklf;Zie);
    Protein name:
    Krueppel-like factor 4;
    Alternative:
    Gut-enriched krueppel-like factor;Epithelial zinc finger protein EZF;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MUC1 (via the C-terminal domain) (By similarity). Interacts with POU5F1/OCT4 and SOX2.
    Function:
    Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    483
    Sequence:
    50:
    MRQPPGESDM | AVSDALLPSF | STFASGPAGR | EKTLRPAGAP | TNRWREELSH | 
    100:
    MKRLPPLPGR | PYDLAATVAT | DLESGGAGAA | CSSNNPALLA | RRETEEFNDL | 
    150:
    LDLDFILSNS | LTHQESVAAT | VTTSASASSS | SSPASSGPAS | APSTCSFSYP | 
    200:
    IRAGGDPGVA | ASNTGGGLLY | SRESAPPPTA | PFNLADINDV | SPSGGFVAEL | 
    250:
    LRPELDPVYI | PPQQPQPPGG | GLMGKFVLKA | SLTTPGSEYS | SPSVISVSKG | 
    300:
    SPDGSHPVVV | APYSGGPPRM | CPKIKQEAVP | SCTVSRSLEA | HLSAGPQLSN | 
    350:
    GHRPNTHDFP | LGRQLPTRTT | PTLSPEELLN | SRDCHPGLPL | PPGFHPHPGP | 
    400:
    NYPPFLPDQM | QSQVPSLHYQ | ELMPPGSCLP | EEPKPKRGRR | SWPRKRTATH | 
    450:
    TCDYAGCGKT | YTKSSHLKAH | LRTHTGEKPY | HCDWDGCGWK | FARSDELTRH | 
    483:
    YRKHTGHRPF | QCQKCDRAFS | RSDHLALHMK | RHF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Krueppel-like factor 4
    ELISA Kit for Mouse Krueppel-like factor 4
    CLIA Kit for Mouse Krueppel-like factor 4
    CLIA Kit for Mouse Krueppel-like factor 4
    Polyclonal Antibody for Mouse Krueppel-like factor 4
    Polyclonal Antibody for Mouse Krueppel-like factor 4
    Monoclonal Antibody for Mouse Krueppel-like factor 4
    Monoclonal Antibody for Mouse Krueppel-like factor 4
    Protein for Mouse Krueppel-like factor 4
    Protein for Mouse Krueppel-like factor 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest."
      Shields J.M. , Christy R.J. , Yang V.W.
      J. Biol. Chem.271:20009-20017(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells."
      Garrett-Sinha L.A. , Eberspaecher H. , Seldin M.F. , de Crombrugghe B.
      J. Biol. Chem.271:31384-31390(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6 X DBA/2.
      tissue: Embryonic fibroblast.
    3. 3.
      "Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)."
      Mahatan C.S. , Kaestner K.H. , Geiman D.E. , Yang V.W.
      Nucleic Acids Res.27:4562-4569(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION
      strain: 129/SvJ.
    4. 4.
      "STAT1 is required for IFN-gamma-mediated gut-enriched Kruppel-like factor expression."
      Chen Z.-Y. , Shie J.-L. , Tseng C.-C.
      Exp. Cell Res.281:19-27(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];INDUCTION
      strain: C57BL/6.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Dendritic cell.
      tissue: Embryonic stem cell.
      tissue: Mammary gland.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    7. 7.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    9. 9.
      "Klf4 is a transcription factor required for establishing the barrier function of the skin."
      Segre J.A. , Bauer C. , Fuchs E.
      Nat. Genet.22:356-360(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DISRUPTION PHENOTYPE
    10. 10.
      "Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4."
      Li Y. , McClintick J. , Zhong L. , Edenberg H.J. , Yoder M.C. , Chan R.J.
      Blood105:635-637(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors."
      Takahashi K. , Yamanaka S.
      Cell126:663-676(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOTECHNOLOGY
    12. 12.
      "Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells."
      Nakatake Y. , Fukui N. , Iwamatsu Y. , Masui S. , Takahashi K. , Yagi R. , Yagi K. , Miyazaki J. , Matoba R. , Ko M.S. , Niwa H.
      Mol. Cell. Biol.26:7772-7782(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells."
      Swamynathan S.K. , Katz J.P. , Kaestner K.H. , Ashery-Padan R. , Crawford M.A. , Piatigorsky J.
      Mol. Cell. Biol.27:182-194(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    14. 14.
      "Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming."
      Wei Z. , Yang Y. , Zhang P. , Andrianakos R. , Hasegawa K. , Lyu J. , Chen X. , Bai G. , Liu C. , Pera M. , Lu W.
      Stem Cells27:2969-2978(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH POU5F1/OCT4 AND SOX2;BIOTECHNOLOGY
    15. 15.
      "Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression."
      Zhang P. , Andrianakos R. , Yang Y. , Liu C. , Lu W.
      J. Biol. Chem.285:9180-9189(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "Crystal structure in complex with DNA."
      Schuetz A. , Zocher G. , Carstanjen D. , Heinemann U.
      Submitted (2010-04) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 395-483 IN COMPLEX WITH ZINC IONS AND DNA
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