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Index > Protein center > KLHL13(Gene name) > Human
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  • KLHL13 (Gene name),
  • Kelch-like protein 13 (Protein name ),  KLH13_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    KLHL13(BKLHD2;KIAA1309);
    Protein name:
    Kelch-like protein 13;
    Alternative:
    BTB and kelch domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.
    Function:
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    655
    Sequence:
    50:
    MPLKWKTSSP | AIWKFPVPVL | KTSRSTPLSP | AYISLVEEED | QHMKLSLGGS | 
    100:
    EMGLSSHLQS | SKAGPTRIFT | SNTHSSVVLQ | GFDQLRLEGL | LCDVTLMPGD | 
    150:
    TDDAFPVHRV | MMASASDYFK | AMFTGGMKEQ | DLMCIKLHGV | SKVGLRKIID | 
    200:
    FIYTAKLSLN | MDNLQDTLEA | ASFLQILPVL | DFCKVFLISG | VTLDNCVEVG | 
    250:
    RIANTYNLTE | VDKYVNSFVL | KNFPALLSTG | EFLKLPFERL | AFVLSSNSLK | 
    300:
    HCTELELFKA | TCRWLRLEEP | RMDFAAKLMK | NIRFPLMTPQ | ELINYVQTVD | 
    350:
    FMRTDNTCVN | LLLEASNYQM | MPYMQPVMQS | DRTAIRSDTT | HLVTLGGVLR | 
    400:
    QQLVVSKELR | MYDEKAHEWK | SLAPMDAPRY | QHGIAVIGNF | LYVVGGQSNY | 
    450:
    DTKGKTAVDT | VFRFDPRYNK | WMQVASLNEK | RTFFHLSALK | GYLYAVGGRN | 
    500:
    AAGELPTVEC | YNPRTNEWTY | VAKMSEPHYG | HAGTVYGGVM | YISGGITHDT | 
    550:
    FQKELMCFDP | DTDKWIQKAP | MTTVRGLHCM | CTVGERLYVI | GGNHFRGTSD | 
    600:
    YDDVLSCEYY | SPILDQWTPI | AAMLRGQSDV | GVAVFENKIY | VVGGYSWNNR | 
    650:
    CMVEIVQKYD | PDKDEWHKVF | DLPESLGGIR | ACTLTVFPPE | ETTPSPSRES | 
    655:
    PLSAP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kelch-like protein 13
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    E14767h
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    ELISA Kit for Human Kelch-like protein 13
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    E14767c
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    ELISA Kit for Human Kelch-like protein 13
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    ELISA Kit for Human Kelch-like protein 13
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    E14767m
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    Packing:
    96T
    CLIA Kit for Human Kelch-like protein 13
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    U14767b
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    Packing:
    96T
    CLIA Kit for Human Kelch-like protein 13
    Cat.:
    U14767h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Kelch-like protein 13
    Cat.:
    U14767m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kelch-like protein 13
    Cat.:
    U14767c
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    Packing:
    96T
    Polyclonal Antibody for Human Kelch-like protein 13
    Cat.:
    P14767Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kelch-like protein 13
    Polyclonal Antibody for Human Kelch-like protein 13
    Cat.:
    P14767Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kelch-like protein 13
    Monoclonal Antibody for Human Kelch-like protein 13
    Monoclonal Antibody for Human Kelch-like protein 13
    Monoclonal Antibody for Human Kelch-like protein 13
    Monoclonal Antibody for Human Kelch-like protein 13
    Protein for Human Kelch-like protein 13
    Protein for Human Kelch-like protein 13
    Protein for Human Kelch-like protein 13
    Protein for Human Kelch-like protein 13

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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    2. 2.
      Howell G.R. , Huckle E. , Ross M.T.
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Testis.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 5)
      tissue: Brain.
      tissue: Testis.
      tissue: Thalamus.
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
      Furukawa M. , He Y.J. , Borchers C. , Xiong Y.
      Nat. Cell Biol.5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE;INTERACTION WITH CUL3
    8. 8.
      "A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells."
      Sumara I. , Quadroni M. , Frei C. , Olma M.H. , Sumara G. , Ricci R. , Peter M.
      Dev. Cell12:887-900(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AURKB; CUL3 AND KLHL9
    9. 9.
      "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."
      Maerki S. , Olma M.H. , Staubli T. , Steigemann P. , Gerlich D.W. , Quadroni M. , Sumara I. , Peter M.
      J. Cell Biol.187:791-800(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-223
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-261
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