Klhl17 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comKlhl17 ELISA Kit for Rat(Rattus norvegicus)

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Klhl17 (Gene name),

Kelch-like protein 17 (Protein name ), KLH17_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Klhl17;

Protein name:

Kelch-like protein 17;

Alternative:

Actinfilin;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with F-actin; the interaction disrupts the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the inteaction regulates surface GRIK2 expression.

Function:

Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane postsynaptic density Cell junction synapse Postsynaptic density.

Protein Attributes:

Sequence length:

640

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

640:

KWVAASCMFT | RRSSVGVAVL | ELLNFPPPSS | PTLSVSSTSL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q8K430

UniGene:

Rn.144676

KEGG:

rno:246757

Pfam:

PF07707

STRING:

10116.ENSRNOP00000027547

String:

Q8K430

Uniprot:

Q8K430

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ELISA Kit for Rat Kelch-like protein 17

Cat.:

E1567h

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Manual:

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Packing:

96T

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ELISA Kit for Rat Kelch-like protein 17

Cat.:

E1567r

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Packing:

96T

ELISA Kit for Rat Kelch-like protein 17

Cat.:

E1567m

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Packing:

96T

CLIA Kit for Rat Kelch-like protein 17

Cat.:

U1567m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Kelch-like protein 17

Cat.:

U1567r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Kelch-like protein 17

Cat.:

U1567h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Kelch-like protein 17

Cat.:

P1567Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Kelch-like protein 17

Cat.:

P1567Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Kelch-like protein 17

Cat.:

P1567Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Kelch-like protein 17

Protein for Rat Kelch-like protein 17

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Actinfilin, a brain-specific actin-binding protein in postsynaptic density."
Chen Y. , Derin R. , Petralia R.S. , Li M.
J. Biol. Chem.277:30495-30501(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH ACTIN
strain: Sprague-Dawley.
2.

"Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons."
Chen Y. , Li M.
Neuropharmacology49:1026-1041(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDZK1; DLG4; SYNGAP1 AND F-ACTIN;MUTAGENESIS OF 638-THR--LEU-640
3.

"Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway."
Salinas G.D. , Blair L.A. , Needleman L.A. , Gonzales J.D. , Chen Y. , Li M. , Singer J.D. , Marshall J.
J. Biol. Chem.281:40164-40173(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GRIK2; GRIK1 AND CUL3

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