Klhl20 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comKlhl20 ELISA Kit for Rat(Rattus norvegicus)

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Klhl20 (Gene name),

Kelch-like protein 20 (Protein name ), KLH20_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Klhl20;

Protein name:

Kelch-like protein 20;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Component of the BCR(KLHL20) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL20 and RBX1. Interacts with DAPK1. Interacts with F-actin. Interacts with IFN-gamma (IFNG).

Function:

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis.

Subcellular Location:

Cytoplasm perinuclear region Nucleus Localizes in the perinuclear region in normal conditions. Following IFN-alpha or IFN-gamma treatment, it is relocalized and sequestrated to the PML nuclear bodies, preventing DAPK1 ubiquitination.

Protein Attributes:

Sequence length:

609

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

609:

MTHCESHIW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.44191

Pfam:

PF07707

SMR:

D3Z8N4

KEGG:

rno:304920

Uniprot:

D3Z8N4

FOR

ELISA Kit for Rat Kelch-like protein 20

CLIA Kit for Rat Kelch-like protein 20

Polyclonal Antibody for Rat Kelch-like protein 20

Monoclonal Antibody for Rat Kelch-like protein 20

Protein for Rat Kelch-like protein 20

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.

"PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth."
Lin M.Y. , Lin Y.M. , Kao T.C. , Chuang H.H. , Chen R.H.
J. Cell Biol.193:985-994(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION

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