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Index > Protein center > KLHL21(Gene name) > Human
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  • KLHL21 (Gene name),
  • Kelch-like protein 21 (Protein name ),  KLH21_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KLHL21(KIAA0469);
    Protein name:
    Kelch-like protein 21;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.
    Function:
    Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
    Subcellular Location:
    Cytoplasm cytoskeleton spindle Localizes to the spindle midzone and targets CUL3 to this region.
    Protein Attributes:
    Sequence length:
    597
    Sequence:
    50:
    MERPAPLAVL | PFSDPAHALS | LLRGLSQLRA | ERKFLDVTLE | AAGGRDFPAH | 
    100:
    RAVLAAASPY | FRAMFAGQLR | ESRAERVRLH | GVPPDMLQLL | LDFSYTGRVA | 
    150:
    VSGDNAEPLL | RAADLLQFPA | VKEACGAFLQ | QQLDLANCLD | MQDFAEAFSC | 
    200:
    SGLASAAQRF | ILRHVGELGA | EQLERLPLAR | LLRYLRDDGL | CVPKEEAAYQ | 
    250:
    LALRWVRADP | PRRAAHWPQL | LEAVRLPFVR | RFYLLAHVEA | EPLVARCPPC | 
    300:
    LRLLREARDF | QAARYDRHDR | GPCPRMRPRP | STGLAEILVL | VGGCDQDCDE | 
    350:
    LVTVDCYNPQ | TGQWRYLAEF | PDHLGGGYSI | VALGNDIYVT | GGSDGSRLYD | 
    400:
    CVWRYNSSVN | EWAEVAPMLK | AREYHSSSVL | DGLLYVVAAD | STERYDHTTD | 
    450:
    SWEALQPMTY | PMDNCSTTAC | RGRLYAIGSL | AGKETMVMQC | YDPDTDLWSL | 
    500:
    VDCGQLPPWS | FAPKTATLNG | LMYFVRDDSA | EVDVYNPTRN | EWDKIPSMNQ | 
    550:
    VHVGGSLAVL | GGKLYVSGGY | DNTFELSDVV | EAYDPETRAW | SVVGRLPEPT | 
    597:
    FWHGSVSIFR | QFMPQTFSGG | RGFELDSGSD | DMDPGRPRPP | RDPDELH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kelch-like protein 21
    ELISA Kit for Human Kelch-like protein 21
    ELISA Kit for Human Kelch-like protein 21
    ELISA Kit for Human Kelch-like protein 21
    CLIA Kit for Human Kelch-like protein 21
    CLIA Kit for Human Kelch-like protein 21
    CLIA Kit for Human Kelch-like protein 21
    CLIA Kit for Human Kelch-like protein 21
    Polyclonal Antibody for Human Kelch-like protein 21
    Polyclonal Antibody for Human Kelch-like protein 21
    Polyclonal Antibody for Human Kelch-like protein 21
    Polyclonal Antibody for Human Kelch-like protein 21
    Monoclonal Antibody for Human Kelch-like protein 21
    Monoclonal Antibody for Human Kelch-like protein 21
    Monoclonal Antibody for Human Kelch-like protein 21
    Monoclonal Antibody for Human Kelch-like protein 21
    Protein for Human Kelch-like protein 21
    Protein for Human Kelch-like protein 21
    Protein for Human Kelch-like protein 21
    Protein for Human Kelch-like protein 21

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
      Seki N. , Ohira M. , Nagase T. , Ishikawa K. , Miyajima N. , Nakajima D. , Nomura N. , Ohara O.
      DNA Res.4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    2. 2.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hippocampus.
      tissue: Lung carcinoma.
    6. 6.
      "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H. , Takano J. , Kikuno R. , Nagase T. , Ohara O.
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-597 (ISOFORM 1)
      tissue: Spleen.
    7. 7.
      Bienvenut W.V. , Dhillon A.S. , Kolch W.
      Submitted (2008-02) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 52-62; 99-122 AND 424-433 (ISOFORMS 1/2);PROTEIN SEQUENCE OF 561-571 (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Hepatoma.
    8. 8.
      "Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases."
      Furukawa M. , He Y.J. , Borchers C. , Xiong Y.
      Nat. Cell Biol.5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE;INTERACTION WITH CUL3
    9. 9.
      "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."
      Maerki S. , Olma M.H. , Staubli T. , Steigemann P. , Gerlich D.W. , Quadroni M. , Sumara I. , Peter M.
      J. Cell Biol.187:791-800(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX;MUTAGENESIS OF 114-ASP--GLN-117
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