Gene name:
KLHL21 (KIAA0469) ;
Protein name:
Kelch-like protein 21 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Subcellular Location:
Cytoplasm
cytoskeleton
spindle
Localizes to the spindle midzone and targets CUL3 to this region.
Protein Attributes:
50:
MERPAPLAVL | PFSDPAHALS | LLRGLSQLRA | ERKFLDVTLE | AAGGRDFPAH |
100:
RAVLAAASPY | FRAMFAGQLR | ESRAERVRLH | GVPPDMLQLL | LDFSYTGRVA |
150:
VSGDNAEPLL | RAADLLQFPA | VKEACGAFLQ | QQLDLANCLD | MQDFAEAFSC |
200:
SGLASAAQRF | ILRHVGELGA | EQLERLPLAR | LLRYLRDDGL | CVPKEEAAYQ |
250:
LALRWVRADP | PRRAAHWPQL | LEAVRLPFVR | RFYLLAHVEA | EPLVARCPPC |
300:
LRLLREARDF | QAARYDRHDR | GPCPRMRPRP | STGLAEILVL | VGGCDQDCDE |
350:
LVTVDCYNPQ | TGQWRYLAEF | PDHLGGGYSI | VALGNDIYVT | GGSDGSRLYD |
400:
CVWRYNSSVN | EWAEVAPMLK | AREYHSSSVL | DGLLYVVAAD | STERYDHTTD |
450:
SWEALQPMTY | PMDNCSTTAC | RGRLYAIGSL | AGKETMVMQC | YDPDTDLWSL |
500:
VDCGQLPPWS | FAPKTATLNG | LMYFVRDDSA | EVDVYNPTRN | EWDKIPSMNQ |
550:
VHVGGSLAVL | GGKLYVSGGY | DNTFELSDVV | EAYDPETRAW | SVVGRLPEPT |
597:
FWHGSVSIFR | QFMPQTFSGG | RGFELDSGSD | DMDPGRPRPP | RDPDELH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
ELISA Kit for Human Kelch-like protein 21
ELISA Kit for Human Kelch-like protein 21
ELISA Kit for Human Kelch-like protein 21
ELISA Kit for Human Kelch-like protein 21
CLIA Kit for Human Kelch-like protein 21
CLIA Kit for Human Kelch-like protein 21
CLIA Kit for Human Kelch-like protein 21
CLIA Kit for Human Kelch-like protein 21
Polyclonal Antibody for Human Kelch-like protein 21
Polyclonal Antibody for Human Kelch-like protein 21
Polyclonal Antibody for Human Kelch-like protein 21
Polyclonal Antibody for Human Kelch-like protein 21
Monoclonal Antibody for Human Kelch-like protein 21
Monoclonal Antibody for Human Kelch-like protein 21
Monoclonal Antibody for Human Kelch-like protein 21
Monoclonal Antibody for Human Kelch-like protein 21
Protein for Human Kelch-like protein 21
Protein for Human Kelch-like protein 21
Protein for Human Kelch-like protein 21
Protein for Human Kelch-like protein 21
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Brain .
2.
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Hippocampus .
tissue :
Lung carcinoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-597 (ISOFORM 1)
tissue :
Spleen .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 52-62; 99-122 AND 424-433 (ISOFORMS 1/2);PROTEIN SEQUENCE OF 561-571 (ISOFORM 1);IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Hepatoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE;INTERACTION WITH CUL3
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN A BCR (BTB-CUL3-RBX1) E3 UBIQUITIN LIGASE COMPLEX;MUTAGENESIS OF 114-ASP--GLN-117