KLK7 ELISA Kit for Human(Homo sapiens) | EIAab.comKLK7 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > KLK7(Gene name) > Human

KLK7 (Gene name),

Kallikrein-7 (Protein name ), KLK7_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

KLK7(PRSS6;SCCE);

Protein name:

Kallikrein-7(hK7);

Alternative:

Stratum corneum chymotryptic enzyme(hSCCE);Serine protease 6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

Subcellular Location:

Secreted In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Protein Attributes:

Sequence length:

253

Sequence:

50:

100:

150:

200:

250:

253:

KHR

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

P49862

KEGG:

hsa:5650

SMR:

P49862

MIM:

604438

Pfam:

PF00089

UniGene:

Hs.151254

STRING:

9606.ENSP00000304791

Uniprot:

P49862

FOR

ELISA Kit for Human hK7

Cat.:

E1910h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human hK7

Cat.:

E1910m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human hK7

Cat.:

E1910r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human hK7

Cat.:

U1910h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human hK7

Cat.:

U1910m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human hK7

Cat.:

U1910r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human hK7

Cat.:

P1910Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human hK7

Cat.:

P1910Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human hK7

Cat.:

P1910Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human hK7

Protein for Human hK7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase."
Hansson L. , Stroemqvist M. , Baeckman A. , Wallbrandt P. , Carlstein A. , Egelrud T.
J. Biol. Chem.269:19420-19426(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 23-53
tissue: Skin.
2.

"The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family -- genomic characterization, mapping, tissue expression and hormonal regulation."
Yousef G.M. , Scorilas A. , Magklara A. , Soosaipillai A. , Diamandis E.P.
Gene254:119-128(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY;INDUCTION
tissue: Keratinocyte.
3.

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gan L. , Lee I. , Smith R. , Argonza-Barrett R. , Lei H. , McCuaig J. , Moss P. , Paeper B. , Wang K.
Gene257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis."
Hansson L. , Backman A. , Ny A. , Edlund M. , Ekholm E. , Ekstrand Hammarstrom B. , Tornell J. , Wallbrandt P. , Wennbo H. , Egelrud T.
J. Invest. Dermatol.118:444-449(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers."
Dong Y. , Kaushal A. , Brattsand M. , Nicklin J. , Clements J.A.
Clin. Cancer Res.9:1710-1720(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Ovarian carcinoma.
6.

"Prostate epithelial cells KLK7 protein."
Mo Z. , Yang X.
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Prostate.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Amygdala.
8.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Skin.
10.

"Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme."
Skytt A. , Stroemqvist M. , Egelrud T.
Biochem. Biophys. Res. Commun.211:586-589(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
11.

"Vaspin inhibits kallikrein 7 by serpin mechanism."
Heiker J.T. , Kloting N. , Kovacs P. , Kuettner E.B. , Strater N. , Schultz S. , Kern M. , Stumvoll M. , Bluher M. , Beck-Sickinger A.G.
Cell. Mol. Life Sci.70:2569-2583(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CLEAVAGE SPECIFICITY FOR INSULIN;ENZYME REGULATION
12.

"Chymotryptic specificity determinants in the 1.0 A structure of the zinc-inhibited human tissue kallikrein 7."
Debela M. , Hess P. , Magdolen V. , Schechter N.M. , Steiner T. , Huber R. , Bode W. , Goettig P.
Proc. Natl. Acad. Sci. U.S.A.104:16086-16091(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) OF 30-253 IN COMPLEX WITH ZINC OR COPPER;ACTIVE SITE;DISULFIDE BONDS;MUTAGENESIS OF HIS-54 AND HIS-109
13.

"Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6)."
Fernandez I.S. , Standker L. , Magert H.J. , Forssmann W.G. , Gimenez-Gallego G. , Romero A.
J. Mol. Biol.377:1488-1497(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-250;DISULFIDE BONDS

Product Feedback Wall

* Email:
*Comments: