"Mutation of the mouse klotho gene leads to a syndrome resembling ageing."
Kuro-o M. , Matsumura Y. , Aizawa H. , Kawaguchi H. , Suga T. , Utsugi T. , Ohyama Y. , Kurabayashi M. , Kaname T. , Kume E. , Iwasaki H. , Iida A. , Shiraki-Iida T. , Nishikawa S. , Nagai R. , Nabeshima Y.
Nature390:45-51(1997) [PubMed] [Europe PMC] [Abstract]

"Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein."
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Biochem. Biophys. Res. Commun.242:626-630(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 13."
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"Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys."
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Biochem. Biophys. Res. Commun.267:597-602(2000) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and expression of a novel klotho-related protein."
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"Severely reduced production of klotho in human chronic renal failure kidney."
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"Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane."
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"Association of human aging with a functional variant of klotho."
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"Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity."
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"The consensus coding sequences of human breast and colorectal cancers."
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Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis."
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J. Clin. Invest.117:2684-2691(2007) [PubMed] [Europe PMC] [Abstract]