KNG1 ELISA Kit for Human(Homo sapiens) | EIAab.comKNG1 ELISA Kit for Human(Homo sapiens)

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KNG1 (Gene name),

Kininogen-1 (Protein name ), KNG1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

KNG1(BDK;KNG);

Protein name:

Kininogen-1;

Alternative:

Fitzgerald factor;Alpha-2-thiol proteinase inhibitor;Williams-Fitzgerald-Flaujeac factor;High molecular weight kininogen(HMWK);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Subcellular Location:

Secreted extracellular space

Protein Attributes:

Sequence length:

644

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

644:

NPISDFPDTT | SPKCPGRPWK | SVSEINPTTQ | MKESYYFDLT | DGLS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P01042

STRING:

9606.ENSP00000265023

SMR:

P01042

KEGG:

hsa:3827

UniGene:

Hs.77741

MIM:

228960

Pfam:

PF00031

Uniprot:

P01042

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ELISA Kit for Human Kininogen-1

Cat.:

E1805r

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96T

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ELISA Kit for Human Kininogen-1

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E1805b

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96T

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ELISA Kit for Human Kininogen-1

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E1805h

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ELISA Kit for Human Kininogen-1

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E1805m

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96T

CLIA Kit for Human Kininogen-1

Cat.:

U1805h

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96T

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CLIA Kit for Human Kininogen-1

Cat.:

U1805b

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96T

CLIA Kit for Human Kininogen-1

Cat.:

U1805r

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MSDS:

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Packing:

96T

CLIA Kit for Human Kininogen-1

Cat.:

U1805m

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96T

Polyclonal Antibody for Human Kininogen-1

Cat.:

P1805Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Kininogen-1

Cat.:

P1805Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Kininogen-1

Cat.:

P1805Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Kininogen-1

Protein for Human Kininogen-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen."
Ohkubo I. , Kurachi K. , Takasawa T. , Shiokawa H. , Sasaki M.
Biochemistry23:5691-5697(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LMW)
2.

"Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens."
Takagaki Y. , Kitamura N. , Nakanishi S.
J. Biol. Chem.260:8601-8609(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS HMW AND LMW)
tissue: Liver.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW)
tissue: Liver.
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW);VARIANT THR-178
tissue: Kidney.
5.

SeattleSNPs variation discovery resource
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-163; THR-178 AND PRO-212
6.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT THR-178
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW);VARIANT MET-197
tissue: Kidney.
9.

"Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication."
Kellermann J. , Lottspeich F. , Henschen A. , Muller-Esterl W.
Eur. J. Biochem.154:471-478(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-380;GLYCOSYLATION AT ASN-169 AND ASN-205;LACK OF GLYCOSYLATION AT ASN-48
10.

"Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites."
Wunderer G. , Walter I. , Mueller E. , Henschen A.
Biol. Chem. Hoppe-Seyler367:1231-1234(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 376-389 (T-KININ);VARIANT 378-LEU--LYS-380 DEL
tissue: Ascites.
11.

"Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions."
Wunderer G. , Walter I. , Eschenbacher B. , Lang M. , Kellermann J. , Kindermann G.
Biol. Chem. Hoppe-Seyler371:977-981(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 376-389 (T-KININ);TISSUE SPECIFICITY;VARIANT 378-LEU--LYS-380 DEL
12.

"The amino acid sequence of the light chain of human high-molecular-mass kininogen."
Lottspeich F. , Kellermann J. , Henschen A. , Foertsch B. , Mueller-Esterl W.
Eur. J. Biochem.152:307-314(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 379-644
13.

"Isolation and identification of hydroxyproline analogues of bradykinin in human urine."
Kato H. , Matsumura Y. , Maeda H.
FEBS Lett.232:252-254(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 380-389;HYDROXYLATION AT PRO-383
14.

"Structural features of plasma kinins and kininogens."
Pierce J.V.
Fed. Proc.27:52-57(1968) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 381-389
15.

"Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage."
Straczek J. , Maachi F. , Le Nguyen D. , Becchi M. , Heulin M.H. , Nabet P. , Belleville F.
FEBS Lett.373:207-211(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 431-434;IDENTIFICATION BY MASS SPECTROMETRY
16.

"Disulfide bonds in bovine HMW kininogens."
Sueyoshi T. , Miyata T. , Kato H. , Iwanaga S.
Seikagaku56:808-808(1984)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
17.

"Structural organization of the human kininogen gene and a model for its evolution."
Kitamura N. , Kitagawa H. , Fukushima D. , Takagaki Y. , Miyata T. , Nakanishi S.
J. Biol. Chem.260:8610-8617(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
18.

"Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer."
Maeda H. , Matsumura Y. , Kato H.
J. Biol. Chem.263:16051-16054(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AMINO-ACID COMPOSITION OF 381-389;HYDROXYLATION AT PRO-383
19.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-294
20.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-169 AND ASN-294
tissue: Plasma.
21.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-48; ASN-169; ASN-205 AND ASN-294
tissue: Plasma.
22.

"An initial characterization of the serum phosphoproteome."
Zhou W. , Ross M.M. , Tessitore A. , Ornstein D. , Vanmeter A. , Liotta L.A. , Petricoin E.F. III
J. Proteome Res.8:5523-5531(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Serum.
23.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-169; ASN-205 AND ASN-294
tissue: Liver.
24.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-48; ASN-205 AND ASN-294
25.

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-294;STRUCTURE OF CARBOHYDRATES
tissue: Cerebrospinal fluid.

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