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Index > Protein center > KNG1(Gene name) > Human
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  • KNG1 (Gene name),
  • Kininogen-1 (Protein name ),  KNG1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KNG1(BDK;KNG);
    Protein name:
    Kininogen-1;
    Alternative:
    Fitzgerald factor;Alpha-2-thiol proteinase inhibitor;Williams-Fitzgerald-Flaujeac factor;High molecular weight kininogen(HMWK);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    644
    Sequence:
    50:
    MKLITILFLC | SRLLLSLTQE | SQSEEIDCND | KDLFKAVDAA | LKKYNSQNQS | 
    100:
    NNQFVLYRIT | EATKTVGSDT | FYSFKYEIKE | GDCPVQSGKT | WQDCEYKDAA | 
    150:
    KAATGECTAT | VGKRSSTKFS | VATQTCQITP | AEGPVVTAQY | DCLGCVHPIS | 
    200:
    TQSPDLEPIL | RHGIQYFNNN | TQHSSLFMLN | EVKRAQRQVV | AGLNFRITYS | 
    250:
    IVQTNCSKEN | FLFLTPDCKS | LWNGDTGECT | DNAYIDIQLR | IASFSQNCDI | 
    300:
    YPGKDFVQPP | TKICVGCPRD | IPTNSPELEE | TLTHTITKLN | AENNATFYFK | 
    350:
    IDNVKKARVQ | VVAGKKYFID | FVARETTCSK | ESNEELTESC | ETKKLGQSLD | 
    400:
    CNAEVYVVPW | EKKIYPTVNC | QPLGMISLMK | RPPGFSPFRS | SRIGEIKEET | 
    450:
    TVSPPHTSMA | PAQDEERDSG | KEQGHTRRHD | WGHEKQRKHN | LGHGHKHERD | 
    500:
    QGHGHQRGHG | LGHGHEQQHG | LGHGHKFKLD | DDLEHQGGHV | LDHGHKHKHG | 
    550:
    HGHGKHKNKG | KKNGKHNGWK | TEHLASSSED | STTPSAQTQE | KTEGPTPIPS | 
    600:
    LAKPGVTVTF | SDFQDSDLIA | TMMPPISPAP | IQSDDDWIPD | IQIDPNGLSF | 
    644:
    NPISDFPDTT | SPKCPGRPWK | SVSEINPTTQ | MKESYYFDLT | DGLS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
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    ELISA Kit for Human Kininogen-1
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    ELISA Kit for Human Kininogen-1
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    ELISA Kit for Human Kininogen-1
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    ELISA Kit for Human Kininogen-1
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    E1805m
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    CLIA Kit for Human Kininogen-1
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    CLIA Kit for Human Kininogen-1
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    U1805b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Kininogen-1
    Cat.:
    U1805r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Kininogen-1
    Cat.:
    U1805m
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    Packing:
    96T
    Polyclonal Antibody for Human Kininogen-1
    Polyclonal Antibody for Human Kininogen-1
    Cat.:
    P1805Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Kininogen-1
    Cat.:
    P1805Rb-r
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    40ug/0.2ml
    Polyclonal Antibody for Human Kininogen-1
    Cat.:
    P1805Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Kininogen-1
    Monoclonal Antibody for Human Kininogen-1
    Monoclonal Antibody for Human Kininogen-1
    Monoclonal Antibody for Human Kininogen-1
    Protein for Human Kininogen-1
    Protein for Human Kininogen-1
    Protein for Human Kininogen-1
    Protein for Human Kininogen-1

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    References
    1. 1.
      "Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen."
      Ohkubo I. , Kurachi K. , Takasawa T. , Shiokawa H. , Sasaki M.
      Biochemistry23:5691-5697(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LMW)
    2. 2.
      "Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens."
      Takagaki Y. , Kitamura N. , Nakanishi S.
      J. Biol. Chem.260:8601-8609(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS HMW AND LMW)
      tissue: Liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW)
      tissue: Liver.
    4. 4.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW);VARIANT THR-178
      tissue: Kidney.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-163; THR-178 AND PRO-212
    6. 6.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT THR-178
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LMW);VARIANT MET-197
      tissue: Kidney.
    9. 9.
      "Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication."
      Kellermann J. , Lottspeich F. , Henschen A. , Muller-Esterl W.
      Eur. J. Biochem.154:471-478(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-380;GLYCOSYLATION AT ASN-169 AND ASN-205;LACK OF GLYCOSYLATION AT ASN-48
    10. 10.
      "Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites."
      Wunderer G. , Walter I. , Mueller E. , Henschen A.
      Biol. Chem. Hoppe-Seyler367:1231-1234(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 376-389 (T-KININ);VARIANT 378-LEU--LYS-380 DEL
      tissue: Ascites.
    11. 11.
      "Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions."
      Wunderer G. , Walter I. , Eschenbacher B. , Lang M. , Kellermann J. , Kindermann G.
      Biol. Chem. Hoppe-Seyler371:977-981(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 376-389 (T-KININ);TISSUE SPECIFICITY;VARIANT 378-LEU--LYS-380 DEL
    12. 12.
      "The amino acid sequence of the light chain of human high-molecular-mass kininogen."
      Lottspeich F. , Kellermann J. , Henschen A. , Foertsch B. , Mueller-Esterl W.
      Eur. J. Biochem.152:307-314(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 379-644
    13. 13.
      "Isolation and identification of hydroxyproline analogues of bradykinin in human urine."
      Kato H. , Matsumura Y. , Maeda H.
      FEBS Lett.232:252-254(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 380-389;HYDROXYLATION AT PRO-383
    14. 14.
      "Structural features of plasma kinins and kininogens."
      Pierce J.V.
      Fed. Proc.27:52-57(1968) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 381-389
    15. 15.
      "Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage."
      Straczek J. , Maachi F. , Le Nguyen D. , Becchi M. , Heulin M.H. , Nabet P. , Belleville F.
      FEBS Lett.373:207-211(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 431-434;IDENTIFICATION BY MASS SPECTROMETRY
    16. 16.
      "Disulfide bonds in bovine HMW kininogens."
      Sueyoshi T. , Miyata T. , Kato H. , Iwanaga S.
      Seikagaku56:808-808(1984)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    17. 17.
      "Structural organization of the human kininogen gene and a model for its evolution."
      Kitamura N. , Kitagawa H. , Fukushima D. , Takagaki Y. , Miyata T. , Nakanishi S.
      J. Biol. Chem.260:8610-8617(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GENE STRUCTURE
    18. 18.
      "Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer."
      Maeda H. , Matsumura Y. , Kato H.
      J. Biol. Chem.263:16051-16054(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AMINO-ACID COMPOSITION OF 381-389;HYDROXYLATION AT PRO-383
    19. 19.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-294
    20. 20.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-169 AND ASN-294
      tissue: Plasma.
    21. 21.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-48; ASN-169; ASN-205 AND ASN-294
      tissue: Plasma.
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-332;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Serum.
    23. 23.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-169; ASN-205 AND ASN-294
      tissue: Liver.
    24. 24.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-48; ASN-205 AND ASN-294
    25. 25.
      "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
      Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-294;STRUCTURE OF CARBOHYDRATES
      tissue: Cerebrospinal fluid.
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