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Index > Protein center > KNTC1(Gene name) > Human
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  • KNTC1 (Gene name),
  • Kinetochore-associated protein 1 (Protein name ),  KNTC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KNTC1(KIAA0166);
    Protein name:
    Kinetochore-associated protein 1;
    Alternative:
    Rough deal homolog(HsROD;Rod;hRod);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ZW10. This interaction is required for stable association with the kinetochore. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH.
    Function:
    Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores.
    Subcellular Location:
    Cytoplasm Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton spindle Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.
    Protein Attributes:
    Sequence length:
    2209
    Sequence:
    50:
    MWNDIELLTN | DDTGSGYLSV | GSRKEHGTAL | YQVDLLVKIS | SEKASLNPKI | 
    100:
    QACSLSDGFI | IVADQSVILL | DSICRSLQLH | LVFDTEVDVV | GLCQEGKFLL | 
    150:
    VGERSGNLHL | IHVTSKQTLL | TNAFVQKAND | ENRRTYQNLV | IEKDGSNEGT | 
    200:
    YYMLLLTYSG | FFCITNLQLL | KIQQAIENVD | FSTAKKLQGQ | IKSSFISTEN | 
    250:
    YHTLGCLSLV | AGDLASEVPV | IIGGTGNCAF | SKWEPDSSKK | GMTVKNLIDA | 
    300:
    EIIKGAKKFQ | LIDNLLFVLD | TDNVLSLWDI | YTLTPVWNWP | SLHVEEFLLT | 
    350:
    TEADSPSSVT | WQGITNLKLI | ALTASANKKM | KNLMVYSLPT | MEILYSLEVS | 
    400:
    SVSSLVQTGI | STDTIYLLEG | VCKNDPKLSE | DSVSVLVLRC | LTEALPENRL | 
    450:
    SRLLHKHRFA | EAESFAIQFG | LDVELVYKVK | SNHILEKLAL | SSVDASEQTE | 
    500:
    WQQLVDDAKE | NLHKIQDDEF | VVNYCLKAQW | ITYETTQEML | NYAKTRLLKK | 
    550:
    EDKTALIYSD | GLKEVLRAHA | KLTTFYGAFG | PEKFSGSSWI | EFLNNEDDLK | 
    600:
    DIFLQLKEGN | LVCAQYLWLR | HRANFESRFD | VKMLESLLNS | MSASVSLQKL | 
    650:
    CPWFKNDVIP | FVRRTVPEGQ | IILAKWLEQA | ARNLELTDKA | NWPENGLQLA | 
    700:
    EIFFTAEKTD | ELGLASSWHW | ISLKDYQNTE | EVCQLRTLVN | NLRELITLHR | 
    750:
    KYNCKLALSD | FEKENTTTIV | FRMFDKVLAP | ELIPSILEKF | IRVYMREHDL | 
    800:
    QEEELLLLYI | EDLLNRCSSK | STSLFETAWE | AKAMAVIACL | SDTDLIFDAV | 
    850:
    LKIMYAAVVP | WSAAVEQLVK | QHLEMDHPKV | KLLQESYKLM | EMKKLLRGYG | 
    900:
    IREVNLLNKE | IMRVVRYILK | QDVPSSLEDA | LKVAQAFMLS | DDEIYSLRII | 
    950:
    DLIDREQGED | CLLLLKSLPP | AEAEKTAERV | IIWARLALQE | EPDHSKEGKA | 
    1000:
    WRMSVAKTSV | DILKILCDIQ | KDNLQKKDEC | EEMLKLFKEV | ASLQENFEVF | 
    1050:
    LSFEDYSNSS | LVADLREQHI | KAHEVAQAKH | KPGSTPEPIA | AEVRSPSMES | 
    1100:
    KLHRQALALQ | MSKQELEAEL | TLRALKDGNI | KTALKKCSDL | FKYHCNADTG | 
    1150:
    KLLFLTCQKL | CQMLADNVPV | TVPVGLNLPS | MIHDLASQAA | TICSPDFLLD | 
    1200:
    ALELCKHTLM | AVELSRQCQM | DDCGILMKAS | FGTHKDPYEE | WSYSDFFSED | 
    1250:
    GIVLESQMVL | PVIYELISSL | VPLAESKRYP | LESTSLPYCS | LNEGDGLVLP | 
    1300:
    VINSISALLQ | NLQESSQWEL | ALRFVVGSFG | TCLQHSVSNF | MNATLSEKLF | 
    1350:
    GETTLVKSRH | VVMELKEKAV | IFIRENATTL | LHKVFNCRLV | DLDLALGYCT | 
    1400:
    LLPQKDVFEN | LWKLIDKAWQ | NYDKILAISL | VGSELASLYQ | EIEMGLKFRE | 
    1450:
    LSTDAQWGIR | LGKLGISFQP | VFRQHFLTKK | DLIKALVENI | DMDTSLILEY | 
    1500:
    CSTFQLDCDA | VLQLFIETLL | HNTNAGQGQG | DASMDSAKRR | HPKLLAKALE | 
    1550:
    MVPLLTSTKD | LVISLSGILH | KLDPYDYEMI | EVVLKVIERA | DEKITNININ | 
    1600:
    QALSILKHLK | SYRRISPPVD | LEYQYMLEHV | ITLPSAAQTR | LPFHLIFFGT | 
    1650:
    AQNFWKILST | ELSEESFPTL | LLISKLMKFS | LDTLYVSTAK | HVFEKKLKPK | 
    1700:
    LLKLTQAKSS | TLINKEITKI | TQTIESCLLS | IVNPEWAVAI | AISLAQDIPE | 
    1750:
    GSFKISALKF | CLYLAERWLQ | NIPSQDEKRE | KAEALLKKLH | IQYRRSGTEA | 
    1800:
    VLIAHKLNTE | EYLRVIGKPA | HLIVSLYEHP | SINQRIQNSS | GTDYPDIHAA | 
    1850:
    AKEIAEVNEI | NLEKVWDMLL | EKWLCPSTKP | GEKPSELFEL | QEDEALRRVQ | 
    1900:
    YLLLSRPIDY | SSRMLFVFAT | STTTTLGMHQ | LTFAHRTRAL | QCLFYLADKE | 
    1950:
    TIESLFKKPI | EEVKSYLRCI | TFLASFETLN | IPITYELFCS | SPKEGMIKGL | 
    2000:
    WKNHSHESMA | VRLVTELCLE | YKIYDLQLWN | GLLQKLLGFN | MIPYLRKVLK | 
    2050:
    AISSIHSLWQ | VPYFSKAWQR | VIQIPLLSAS | CPLSPDQLSD | CSESLIAVLE | 
    2100:
    CPVSGDLDLI | GVARQYIQLE | LPAFALACLM | LMPHSEKRHQ | QIKNFLGSCD | 
    2150:
    PQVILKQLEE | HMNTGQLAGF | SHQIRSLILN | NIINKKEFGI | LAKTKYFQML | 
    2200:
    KMHAMNTNNI | TELVNYLAND | LSLDEASVLI | TEYSKHCGKP | VPPDTAPCEI | 
    2209:
    LKMFLSGLS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kinetochore-associated protein 1
    ELISA Kit for Human Kinetochore-associated protein 1
    CLIA Kit for Human Kinetochore-associated protein 1
    CLIA Kit for Human Kinetochore-associated protein 1
    Polyclonal Antibody for Human Kinetochore-associated protein 1
    Polyclonal Antibody for Human Kinetochore-associated protein 1
    Monoclonal Antibody for Human Kinetochore-associated protein 1
    Monoclonal Antibody for Human Kinetochore-associated protein 1
    Protein for Human Kinetochore-associated protein 1
    Protein for Human Kinetochore-associated protein 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Seki N. , Ishikawa K. , Tanaka A. , Nomura N.
      DNA Res.3:17-24(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores."
      Chan G.K.T. , Jablonski S.A. , Starr D.A. , Goldberg M.L. , Yen T.J.
      Nat. Cell Biol.2:944-947(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore."
      Scaeerou F. , Starr D.A. , Piano F. , Papoulas O. , Karess R.E. , Goldberg M.L.
      J. Cell Sci.114:3103-3114(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions."
      Williams B.C. , Li Z. , Liu S. , Williams E.V. , Leung G. , Yen T.J. , Goldberg M.L.
      Mol. Biol. Cell14:1379-1391(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZWILCH AND ZW10
    9. 9.
      "ZW10 links mitotic checkpoint signaling to the structural kinetochore."
      Kops G.J.P.L. , Kim Y. , Weaver B.A.A. , Mao Y. , McLeod I. , Yates J.R. III , Tagaya M. , Cleveland D.W.
      J. Cell Biol.169:49-60(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE RZZ COMPLEX
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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