Prkd1 ELISA Kit for Mouse(Mus musculus) | EIAab.comPrkd1 ELISA Kit for Mouse(Mus musculus)

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Prkd1 (Gene name),

Serine/threonine-protein kinase D1 (Protein name ), KPCD1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Prkd1(Pkcm;Pkd;Prkcm);

Protein name:

Serine/threonine-protein kinase D1;

Alternative:

Protein kinase D;Protein kinase C mu type;nPKC-mu;nPKC-D1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with Src.

Function:

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-kappa-B.

Subcellular Location:

Cytoplasm Membrane Translocation to the cell membrane is required for kinase activation.

Protein Attributes:

Sequence length:

918

Sequence:

50:

100:

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300:

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550:

600:

650:

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918:

PEAEEREMKA | LSERVSIL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q62101

KEGG:

mmu:18760

UniGene:

Mm.133719

String:

Q62101

STRING:

10090.ENSMUSP00000002765

Pfam:

PF00130

Uniprot:

Q62101

FOR

ELISA Kit for Mouse Serine/threonine-protein kinase D1

CLIA Kit for Mouse Serine/threonine-protein kinase D1

Polyclonal Antibody for Mouse Serine/threonine-protein kinase D1

Monoclonal Antibody for Mouse Serine/threonine-protein kinase D1

Protein for Mouse Serine/threonine-protein kinase D1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain."
Valverde A.M. , Sinnet-Smith J. , Van Lint J. , Rozengurt E.
Proc. Natl. Acad. Sci. U.S.A.91:8572-8576(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
tissue: Lung.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/protein kinase Cmu."
Matthews S.A. , Rozengurt E. , Cantrell D.
J. Biol. Chem.274:26543-26549(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-916
4.

"Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network."
Liljedahl M. , Maeda Y. , Colanzi A. , Ayala I. , Van Lint J. , Malhotra V.
Cell104:409-420(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF TRANS-GOLGI NETWORK;SUBCELLULAR LOCATION
5.

"Activation loop Ser744 and Ser748 in protein kinase D are transphosphorylated in vivo."
Waldron R.T. , Rey O. , Iglesias T. , Tugal T. , Cantrell D. , Rozengurt E.
J. Biol. Chem.276:32606-32615(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-744 AND SER-748
6.

"The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins."
Wang Y. , Waldron R.T. , Dhaka A. , Patel A. , Riley M.M. , Rozengurt E. , Colicelli J.
Mol. Cell. Biol.22:916-926(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RIN1 PHOSPHORYLATION
7.

"Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain."
Waldron R.T. , Rozengurt E.
J. Biol. Chem.278:154-163(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;MUTAGENESIS OF SER-744 AND SER-748;PHOSPHORYLATION AT SER-744 AND SER-748
8.

"PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions."
Woods A.J. , White D.P. , Caswell P.T. , Norman J.C.
EMBO J.23:2531-2543(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION
9.

"Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells."
Sinnett-Smith J. , Zhukova E. , Hsieh N. , Jiang X. , Rozengurt E.
J. Biol. Chem.279:16883-16893(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION
10.

"Bone morphogenic protein 2 activates protein kinase D to regulate histone deacetylase 7 localization and repression of Runx2."
Jensen E.D. , Gopalakrishnan R. , Westendorf J.J.
J. Biol. Chem.284:2225-2234(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION
11.

"Protein kinase D is implicated in the reversible commitment to differentiation in primary cultures of mouse keratinocytes."
Jadali A. , Ghazizadeh S.
J. Biol. Chem.285:23387-23397(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL PROLIFERATION

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