PSKH1 ELISA Kit for Human(Homo sapiens) | EIAab.comPSKH1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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PSKH1 (Gene name),

Serine/threonine-protein kinase H1 (Protein name ), KPSH1_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

PSKH1;

Protein name:

Serine/threonine-protein kinase H1;

Alternative:

Protein serine kinase H1(PSK-H1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Subcellular Location:

Golgi apparatus Cytoplasm cytoskeleton centrosome Nucleus speckle Endoplasmic reticulum membrane Lipid-anchor Cell membrane Lipid-anchor Cytoplasm Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.

Protein Attributes:

Sequence length:

424

Sequence:

50:

MGCGTSKVLP | EPPKDVQLDL | VKKVEPFSGT | KSDVYKHFIT | EVDSVGPVKA |

100:

GFPAASQYAH | PCPGPPTAGH | TEPPSEPPRR | ARVAKYRAKF | DPRVTAKYDI |

150:

KALIGRGSFS | RVVRVEHRAT | RQPYAIKMIE | TKYREGREVC | ESELRVLRRV |

200:

RHANIIQLVE | VFETQERVYM | VMELATGGEL | FDRIIAKGSF | TERDATRVLQ |

250:

MVLDGVRYLH | ALGITHRDLK | PENLLYYHPG | TDSKIIITDF | GLASARKKGD |

300:

DCLMKTTCGT | PEYIAPEVLV | RKPYTNSVDM | WALGVIAYIL | LSGTMPFEDD |

350:

NRTRLYRQIL | RGKYSYSGEP | WPSVSNLAKD | FIDRLLTVDP | GARMTALQAL |

400:

RHPWVVSMAA | SSSMKNLHRS | ISQNLLKRAS | SRCQSTKSAQ | STRSSRSTRS |

424:

NKSRRVRERE | LRELNLRYQQ | QYNG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

MIM:

UniGene:

STRING:

9606.ENSP00000291041

String:

KEGG:

Pfam:

Uniprot:

FOR

ELISA Kit for Human Serine/threonine-protein kinase H1

ELISA Kit for Human Serine/threonine-protein kinase H1

ELISA Kit for Human Serine/threonine-protein kinase H1

CLIA Kit for Human Serine/threonine-protein kinase H1

CLIA Kit for Human Serine/threonine-protein kinase H1

CLIA Kit for Human Serine/threonine-protein kinase H1

Polyclonal Antibody for Human Serine/threonine-protein kinase H1

Polyclonal Antibody for Human Serine/threonine-protein kinase H1

Polyclonal Antibody for Human Serine/threonine-protein kinase H1

Monoclonal Antibody for Human Serine/threonine-protein kinase H1

Monoclonal Antibody for Human Serine/threonine-protein kinase H1

Monoclonal Antibody for Human Serine/threonine-protein kinase H1

Protein for Human Serine/threonine-protein kinase H1

Protein for Human Serine/threonine-protein kinase H1

Protein for Human Serine/threonine-protein kinase H1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Characterization of PSKH1, a novel human protein serine kinase with centrosomal, Golgi, and nuclear localization."
Brede G. , Solheim J. , Troen G. , Prydz H.
Genomics70:82-92(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION;HOMODIMERIZATION;MUTAGENESIS OF ASP-218
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
3.

"Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family."
Hanks S.K.
Proc. Natl. Acad. Sci. U.S.A.84:388-392(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-348
4.

"PSKH1, a novel splice factor compartment-associated serine kinase."
Brede G. , Solheim J. , Prydz H.
Nucleic Acids Res.30:5301-5309(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus."
Brede G. , Solheim J. , Stang E. , Prydz H.
Exp. Cell Res.291:299-312(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT GLY-2;PALMITOYLATION AT CYS-3;SUBCELLULAR LOCATION
6.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-301

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