Protein name:
Kremen protein 2 ;
Alternative:
Kringle domain-containing transmembrane protein 2 ;Dickkopf receptor 2 ;Kringle-containing protein marking the eye and the nose ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ERLEC1.
Function:
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MGTPHLQGFL | LLFPLLLRLH | GASAGSLHSP | GLSECFQVNG | ADYRGHQNYT |
100:
GPRGAGRPCL | FWDQTQQHSY | SSASDPQGRW | GLGAHNFCRN | PDGDVQPWCY |
150:
VAETEEGIYW | RYCDIPTCHM | PGYLGCFVDS | GAPPALSGPS | GTSTKLTVQV |
200:
CLRFCRMKGY | QLAGVEAGYA | CFCGSESDLA | RGRPAPATDC | DQICFGHPGQ |
250:
LCGGDGRLGI | YEVSVGSCQG | NWSAPQGVIY | SPDFPDEYGP | DRNCSWVLGQ |
300:
LGAVLELTFR | LFELADSRDR | LELRDVSSGN | LLRAFDGAHP | PPPGPLRLRT |
350:
AALLLTFRSD | ARGHAQGFAL | TYRGLQDTVE | GRASPEDSTE | SLAGDPDGAN |
400:
ASCSPKPGAA | QASIGARVFS | TVTAFSVLLL | LLLSLLRLLR | RRSCLLAPGK |
450:
GSLAMGPSRG | PGRSWAVWYR | RPRGVALPCP | PGDSQAEGPA | AGYRPLSASS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Kremen protein 2
ELISA Kit for Mouse Kremen protein 2
CLIA Kit for Mouse Kremen protein 2
CLIA Kit for Mouse Kremen protein 2
Polyclonal Antibody for Mouse Kremen protein 2
Polyclonal Antibody for Mouse Kremen protein 2
Monoclonal Antibody for Mouse Kremen protein 2
Monoclonal Antibody for Mouse Kremen protein 2
Protein for Mouse Kremen protein 2
Protein for Mouse Kremen protein 2
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling."
Mao B.
,
Wu W.
,
Davidson G.
,
Marhold J.
,
Li M.
,
Mechler B.M.
,
Delius H.
,
Hoppe D.
,
Stannek P.
,
Walter C.
,
Glinka A.
,
Niehrs C.
Nature417:664-667(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ERLEC1