Krev interaction trapped protein 1 (Protein name
), KRIT1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
KRIT1(CCM1);
Protein name:
Krev interaction trapped protein 1(Krev interaction trapped 1);
Alternative:
Cerebral cavernous malformations 1 protein;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RAP1A. Interacts with CDH5.
Function:
Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, and inhibits EKR1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2. Facilitates the down-regulation of cyclin D1 levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels.
Subcellular Location:
Membrane
Peripheral membrane protein
Cell junction
KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;INTERACTION WITH RAP1A
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING;VARIANTS CCM1 SER-97 AND GLU-569
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-243;ALTERNATIVE SPLICING
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Cited for: FUNCTION;INTERACTION WITH ITGB1 AND ITGB1BP1;MUTAGENESIS OF ASN-192 AND TYR-195
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Cited for: INTERACTION WITH ITGB1BP1;MUTAGENESIS OF ASN-192 AND TYR-195
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Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH ITGB1BP1 AND RAP1A;INTERACTION WITH ITGB1BP1 AND RAP1A;SUBCELLULAR LOCATION;MUTAGENESIS OF 47-LYS--LYS-50 AND 192-ASN--TYR-195
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CDH5
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH RAP1A;MUTAGENESIS OF ARG-452
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Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 420-736 IN COMPLEX WITH RAP1B;MUTAGENESIS OF SER-430; ARG-432 AND ARG-452;INTERACTION WITH RAP1B
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Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 417-736 IN COMPLEX WITH HEG1;INTERACTION WITH HEG1; RAP1A AND CCM2;SUBCELLULAR LOCATION;MUTAGENESIS OF LEU-717 AND LEU-721
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Cited for: X-RAY CRYSTALLOGRAPHY (2.54 ANGSTROMS) OF 1-198 IN COMPLEX WITH ITGB1BP1;INTERACTION WITH ITGB1BP1;FUNCTION;DOMAIN;MUTAGENESIS OF ALA-176; ARG-179; PRO-182; ARG-185; ASN-192 AND TYR-195
Vaild Sequence:
