Ksr1 ELISA Kit for Mouse(Mus musculus) | EIAab.comKsr1 ELISA Kit for Mouse(Mus musculus)

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Ksr1 (Gene name),

Kinase suppressor of Ras 1 (Protein name ), KSR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ksr1(Ksr);

Protein name:

Kinase suppressor of Ras 1(mKSR1);

Alternative:

Protein Hb;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. Interacts with VRK2.

Function:

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Endoplasmic reticulum membrane In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.

Protein Attributes:

Sequence length:

873

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

873:

SSKVMPRFER | FGLGTLESGN | PKM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q61097

Pfam:

PF07714

KEGG:

mmu:16706

String:

Q61097

UniGene:

Mm.4745

Pfam:

PF13543

Uniprot:

Q61097

FOR

ELISA Kit for Mouse mKSR1

Cat.:

E14081m

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Manual:

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Packing:

96T

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ELISA Kit for Mouse mKSR1

Cat.:

E14081h

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Manual:

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Packing:

96T

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CLIA Kit for Mouse mKSR1

Cat.:

U14081h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Mouse mKSR1

Cat.:

U14081m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse mKSR1

Cat.:

P14081Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse mKSR1

Cat.:

P14081Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse mKSR1

Protein for Mouse mKSR1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"KSR, a novel protein kinase required for RAS signal transduction."
Therrien M. , Chang H.C. , Solomon N.M. , Karim F.D. , Wassarman D.A. , Rubin G.M.
Cell83:879-888(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH HSPCA; YWHAB; CDC37 AND MAP2K
2.

"Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling."
Mueller J. , Cacace A.M. , Lyons W.E. , McGill C.B. , Morrison D.K.
Mol. Cell. Biol.20:5529-5539(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2);INTERACTION WITH MAPK;MUTAGENESIS OF GLY-572; ARG-589; ARG-615; ASP-700 AND CYS-809;TISSUE SPECIFICITY
tissue: Brain.
3.

Pelan S.
Submitted (2004-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4cM interval on mouse chromosome 11."
Nehls M. , Luno K. , Schorpp M. , Pfeifer D. , Krause S. , Matysiak-Scholze U. , Dierbach H. , Boehm T.
Mamm. Genome6:321-331(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-474 (ISOFORMS 1/2)
strain: BALB/c.
5.

"C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1."
Mueller J. , Ory S. , Copeland T. , Piwnica-Worms H. , Morrison D.K.
Mol. Cell8:983-993(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MARK3;PHOSPHORYLATION AT SER-297 AND SER-392;MUTAGENESIS OF SER-297; SER-392; ILE-397 AND VAL-401
6.

"Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites."
Ory S. , Zhou M. , Conrads T.P. , Veenstra T.D. , Morrison D.K.
Curr. Biol.13:1356-1364(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPP2R1A AND PPP2CA;DEPHOSPHORYLATION BY PPP2CA
7.

"MAP kinase module: the Ksr connection."
Roy F. , Therrien M.
Curr. Biol.12:R325-R327(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
8.

"Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)."
Zhou M. , Horita D.A. , Waugh D.S. , Byrd R.A. , Morrison D.K.
J. Mol. Biol.315:435-446(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 331-378 IN COMPLEX WITH ZINC

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