LNPEP ELISA Kit for Human(Homo sapiens) | EIAab.comLNPEP ELISA Kit for Human(Homo sapiens)

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LNPEP (Gene name),

Leucyl-cystinyl aminopeptidase (Protein name ), LCAP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LNPEP(OTASE);

Protein name:

Leucyl-cystinyl aminopeptidase(Cystinyl aminopeptidase);

Alternative:

Insulin-responsive aminopeptidase(IRAP);Insulin-regulated membrane aminopeptidase;Placental leucine aminopeptidase(P-LAP);Oxytocinase(OTase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Binds tankyrases 1 and 2.

Function:

Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.

Subcellular Location:

Leucyl-cystinyl aminopeptidase, pregnancy serum form Secreted During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.

Protein Attributes:

Sequence length:

1025

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1025:

QEALEVIQLN | IQWMEKNLKS | LTWWL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9UIQ6

KEGG:

hsa:4012

MIM:

151300

Pfam:

PF01433

UniGene:

Hs.527199

STRING:

9606.ENSP00000231368

Pfam:

PF11838

SMR:

Q9UIQ6

Uniprot:

Q9UIQ6

FOR

ELISA Kit for Human Cystinyl aminopeptidase

Cat.:

E13522h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Cystinyl aminopeptidase

Cat.:

E13522r

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human Cystinyl aminopeptidase

Cat.:

E13522m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Cystinyl aminopeptidase

Cat.:

U13522h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Cystinyl aminopeptidase

MSDS:

Please sign in first.

CLIA Kit for Human Cystinyl aminopeptidase

Cat.:

U13522m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Cystinyl aminopeptidase

Monoclonal Antibody for Human Cystinyl aminopeptidase

Protein for Human Cystinyl aminopeptidase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family."
Rogi T. , Tsujimoto M. , Nakazato H. , Mizutani S. , Tomoda Y.
J. Biol. Chem.271:56-61(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 160-168; 319-332; 615-624; 635-647; 798-814 AND 870-880;TISSUE SPECIFICITY
tissue: Placenta.
2.

"The complete amino acid sequence of human placental oxytocinase."
Laustsen P.G. , Rasmussen T.E. , Petersen K. , Pedraza-Diaz S. , Moestrup S.K. , Gliemann J. , Sottrup-Jensen L. , Kristensen T.
Biochim. Biophys. Acta1352:1-7(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
tissue: Placenta.
3.

"Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21."
Rasmussen T.E. , Pedraza-Diaz S. , Hardre R. , Laustsen P.G. , Carrion A.G. , Kristensen T.
Eur. J. Biochem.267:2297-2306(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3)
4.

"Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides."
Matsumoto H. , Nagasaka T. , Hattori A. , Rogi T. , Tsuruoka N. , Mizutani S. , Tsujimoto M.
Eur. J. Biochem.268:3259-3266(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-1025
tissue: Brain.
6.

"Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules."
Falk K. , Roetzschke O. , Stevanovic S. , Jung G. , Rammensee H.G.
Immunogenetics39:230-242(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 285-301 AND 710-724
7.

"Identification of human placental leucine aminopeptidase as oxytocinase."
Tsujimoto M. , Mizutani S. , Adachi H. , Kimura M. , Nakazato H. , Tomoda Y.
Arch. Biochem. Biophys.292:388-392(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
8.

"Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase."
Albiston A.L. , McDowall S.G. , Matsacos D. , Sim P. , Clune E. , Mustafa T. , Lee J. , Mendelsohn F.A. , Simpson R.J. , Connolly L.M. , Chai S.Y.
J. Biol. Chem.276:48623-48626(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-448; ASN-682 AND ASN-850
tissue: Leukemic T-cell.
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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