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Index > Protein center > LNPEP(Gene name) > Human
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  • LNPEP (Gene name),
  • Leucyl-cystinyl aminopeptidase (Protein name ),  LCAP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LNPEP(OTASE);
    Protein name:
    Leucyl-cystinyl aminopeptidase(Cystinyl aminopeptidase);
    Alternative:
    Insulin-responsive aminopeptidase(IRAP);Insulin-regulated membrane aminopeptidase;Placental leucine aminopeptidase(P-LAP);Oxytocinase(OTase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Binds tankyrases 1 and 2.
    Function:
    Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
    Subcellular Location:
    Leucyl-cystinyl aminopeptidase, pregnancy serum form Secreted During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
    Protein Attributes:
    Sequence length:
    1025
    Sequence:
    50:
    MEPFTNDRLQ | LPRNMIENSM | FEEEPDVVDL | AKEPCLHPLE | PDEVEYEPRG | 
    100:
    SRLLVRGLGE | HEMEEDEEDY | ESSAKLLGMS | FMNRSSGLRN | SATGYRQSPD | 
    150:
    GACSVPSART | MVVCAFVIVV | AVSVIMVIYL | LPRCTFTKEG | CHKKNQSIGL | 
    200:
    IQPFATNGKL | FPWAQIRLPT | AVVPLRYELS | LHPNLTSMTF | RGSVTISVQA | 
    250:
    LQVTWNIILH | STGHNISRVT | FMSAVSSQEK | QAEILEYAYH | GQIAIVAPEA | 
    300:
    LLAGHNYTLK | IEYSANISSS | YYGFYGFSYT | DESNEKKYFA | ATQFEPLAAR | 
    350:
    SAFPCFDEPA | FKATFIIKII | RDEQYTALSN | MPKKSSVVLD | DGLVQDEFSE | 
    400:
    SVKMSTYLVA | FIVGEMKNLS | QDVNGTLVSI | YAVPEKIGQV | HYALETTVKL | 
    450:
    LEFFQNYFEI | QYPLKKLDLV | AIPDFEAGAM | ENWGLLTFRE | ETLLYDSNTS | 
    500:
    SMADRKLVTK | IIAHELAHQW | FGNLVTMKWW | NDLWLNEGFA | TFMEYFSLEK | 
    550:
    IFKELSSYED | FLDARFKTMK | KDSLNSSHPI | SSSVQSSEQI | EEMFDSLSYF | 
    600:
    KGSSLLLMLK | TYLSEDVFQH | AVVLYLHNHS | YASIQSDDLW | DSFNEVTNQT | 
    650:
    LDVKRMMKTW | TLQKGFPLVT | VQKKGKELFI | QQERFFLNMK | PEIQPSDTSY | 
    700:
    LWHIPLSYVT | EGRNYSKYQS | VSLLDKKSGV | INLTEEVLWV | KVNINMNGYY | 
    750:
    IVHYADDDWE | ALIHQLKINP | YVLSDKDRAN | LINNIFELAG | LGKVPLKRAF | 
    800:
    DLINYLGNEN | HTAPITEALF | QTDLIYNLLE | KLGYMDLASR | LVTRVFKLLQ | 
    850:
    NQIQQQTWTD | EGTPSMRELR | SALLEFACTH | NLGNCSTTAM | KLFDDWMASN | 
    900:
    GTQSLPTDVM | TTVFKVGAKT | DKGWSFLLGK | YISIGSEAEK | NKILEALASS | 
    950:
    EDVRKLYWLM | KSSLNGDNFR | TQKLSFIIRT | VGRHFPGHLL | AWDFVKENWN | 
    1000:
    KLVQKFPLGS | YTIQNIVAGS | TYLFSTKTHL | SEVQAFFENQ | SEATFRLRCV | 
    1025:
    QEALEVIQLN | IQWMEKNLKS | LTWWL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    MIM:
    Pfam:
    UniGene:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cystinyl aminopeptidase
    Cat.:
    E13522h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cystinyl aminopeptidase
    Cat.:
    E13522r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Cystinyl aminopeptidase
    Cat.:
    E13522m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cystinyl aminopeptidase
    Cat.:
    U13522h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cystinyl aminopeptidase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cystinyl aminopeptidase
    Cat.:
    U13522m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Cystinyl aminopeptidase
    Polyclonal Antibody for Human Cystinyl aminopeptidase
    Polyclonal Antibody for Human Cystinyl aminopeptidase
    Monoclonal Antibody for Human Cystinyl aminopeptidase
    Monoclonal Antibody for Human Cystinyl aminopeptidase
    Monoclonal Antibody for Human Cystinyl aminopeptidase
    Protein for Human Cystinyl aminopeptidase
    Protein for Human Cystinyl aminopeptidase
    Protein for Human Cystinyl aminopeptidase

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family."
      Rogi T. , Tsujimoto M. , Nakazato H. , Mizutani S. , Tomoda Y.
      J. Biol. Chem.271:56-61(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 160-168; 319-332; 615-624; 635-647; 798-814 AND 870-880;TISSUE SPECIFICITY
      tissue: Placenta.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
      tissue: Placenta.
    3. 3.
      "Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21."
      Rasmussen T.E. , Pedraza-Diaz S. , Hardre R. , Laustsen P.G. , Carrion A.G. , Kristensen T.
      Eur. J. Biochem.267:2297-2306(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3)
    4. 4.
      "Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides."
      Matsumoto H. , Nagasaka T. , Hattori A. , Rogi T. , Tsuruoka N. , Mizutani S. , Tsujimoto M.
      Eur. J. Biochem.268:3259-3266(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 206-1025
      tissue: Brain.
    6. 6.
      "Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules."
      Falk K. , Roetzschke O. , Stevanovic S. , Jung G. , Rammensee H.G.
      Immunogenetics39:230-242(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 285-301 AND 710-724
    7. 7.
      "Identification of human placental leucine aminopeptidase as oxytocinase."
      Tsujimoto M. , Mizutani S. , Adachi H. , Kimura M. , Nakazato H. , Tomoda Y.
      Arch. Biochem. Biophys.292:388-392(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY
    8. 8.
      "Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase."
      Albiston A.L. , McDowall S.G. , Matsacos D. , Sim P. , Clune E. , Mustafa T. , Lee J. , Mendelsohn F.A. , Simpson R.J. , Connolly L.M. , Chai S.Y.
      J. Biol. Chem.276:48623-48626(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184; ASN-448; ASN-682 AND ASN-850
      tissue: Leukemic T-cell.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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