Protein name:
Phosphatidylcholine-sterol acyltransferase ;
Alternative:
Phospholipid-cholesterol acyltransferase ;Lecithin-cholesterol acyltransferase ;
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines.
Subcellular Location:
Secreted
Secreted into blood plasma.
Protein Attributes:
50:
GRTGAGFTLL | TLLLLLPQPT | SQFWLFNVLF | PPTTTPEAPP | TNSTPPWCLV |
100:
PGFLGNQLEA | KLDKPDVVNW | MCYRKTEDYF | TIWLNLNTFL | PVGVDCWIDN |
150:
TRVVYNRTAR | KMTNAPGVHI | RVPGFGKTYS | VEYLDQSKLA | GYLHTLVQNL |
200:
VNNGYVRDQT | VRAAPYDWRV | GPQEQPEYFQ | NLKALIEEMH | DEYQQRVFLI |
250:
GHSMGNLNVL | YFLLQQKQAW | KDQYIGGFIS | LGAPWGGSVK | PLRVLASGDN |
300:
QGIPLMSNIK | LREEQRMTTT | SPWMFPTSLA | WPEDHVFIST | PSYNYTYRDY |
350:
QRFFTDVNLE | DGWYMWEDMK | DLLKGLPPPG | VDTYCLYGTG | YPTVETYIYD |
400:
EHFPYEDPVD | MIYGDGDDTV | NKRSSELCKR | WRNQQKQKVH | VQELRGIDHL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Rabbit
Chicken
Rat
Mouse
ELISA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
ELISA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
ELISA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
ELISA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
ELISA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
ELISA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
CLIA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
CLIA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
CLIA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
CLIA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
CLIA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
CLIA Kit for Chicken Phosphatidylcholine-sterol acyltransferase
Polyclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Polyclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Polyclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Polyclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Polyclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Polyclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Monoclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Monoclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Monoclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Monoclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Monoclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Monoclonal Antibody for Chicken Phosphatidylcholine-sterol acyltransferase
Protein for Chicken Phosphatidylcholine-sterol acyltransferase
Protein for Chicken Phosphatidylcholine-sterol acyltransferase
Protein for Chicken Phosphatidylcholine-sterol acyltransferase
Protein for Chicken Phosphatidylcholine-sterol acyltransferase
Protein for Chicken Phosphatidylcholine-sterol acyltransferase
Protein for Chicken Phosphatidylcholine-sterol acyltransferase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain :
White leghorn .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBSTRATE SPECIFICITY