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Index > Protein center > LIF(Gene name) > Human
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  • LIF (Gene name),
  • Leukemia inhibitory factor (Protein name ),  LIF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LIF(HILDA);
    Protein name:
    Leukemia inhibitory factor(LIF);
    Alternative:
    Melanoma-derived LPL inhibitor(MLPLI);Differentiation-stimulating factor(D factor);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    202
    Sequence:
    50:
    MKVLAAGVVP | LLLVLHWKHG | AGSPLPITPV | NATCAIRHPC | HNNLMNQIRS | 
    100:
    QLAQLNGSAN | ALFILYYTAQ | GEPFPNNLDK | LCGPNVTDFP | PFHANGTEKA | 
    150:
    KLVELYRIVV | YLGTSLGNIT | RDQKILNPSA | LSLHSKLNAT | ADILRGLLSN | 
    200:
    VLCRLCSKYH | VGHVDVTYGP | DTSGKDVFQK | KKLGCQLLGK | YKQIIAVLAQ | 
    202:
    AF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    MIM:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human LIF
    Cat.:
    E0085h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LIF
    Cat.:
    E0085m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human LIF
    Cat.:
    E0085b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human LIF
    Cat.:
    E0085r
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    Packing:
    96T
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    CLIA Kit for Human LIF
    Cat.:
    U0085r
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human LIF
    Cat.:
    U0085m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LIF
    Cat.:
    U0085b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LIF
    Cat.:
    U0085h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human LIF
    Polyclonal Antibody for Human LIF
    Cat.:
    P0085Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LIF
    Cat.:
    P0085Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LIF
    Cat.:
    P0085Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LIF
    Monoclonal Antibody for Human LIF
    Monoclonal Antibody for Human LIF
    Monoclonal Antibody for Human LIF
    Protein for Human LIF
    Protein for Human LIF
    Protein for Human LIF
    Protein for Human LIF

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    Linearity
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    References
    1. 1.
      "Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells."
      Moreau J.-F. , Donaldson D.D. , Bennett F. , Witek-Giannotti J. , Clark S.C. , Wong G.G.
      Nature336:690-692(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Genomic cloning and heterologous expression of human differentiation-stimulating factor."
      Lowe D.G. , Nunes W. , Bombara M. , McCabe S. , Ranges G.E. , Henzel W. , Tomida M. , Yamamoto-Yamaguchi Y. , Hozumi M. , Goeddel D.V.
      DNA8:351-359(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."
      Brandenberger R. , Wei H. , Zhang S. , Lei S. , Murage J. , Fisk G.J. , Li Y. , Xu C. , Fang R. , Guegler K. , Rao M.S. , Mandalam R. , Lebkowski J. , Stanton L.W.
      Nat. Biotechnol.22:707-716(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Embryonic stem cell.
    4. 4.
      "Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions."
      Stahl J. , Gearing D.P. , Willson T.A. , Brown M.A. , King J.A. , Gough N.M.
      J. Biol. Chem.265:8833-8841(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Colon.
    9. 9.
      "Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor."
      Gough N.M. , Gearing D.P. , King J.A. , Willson T.A. , Hilton D.J. , Nicola N.A. , Metcalf D.
      Proc. Natl. Acad. Sci. U.S.A.85:2623-2627(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-202
    10. 10.
      "Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia."
      Mori M. , Yamaguchi K. , Abe K.
      Biochem. Biophys. Res. Commun.160:1085-1092(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-39
    11. 11.
      "Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor."
      Schmelzer C.H. , Harris R.J. , Butler D. , Yedinak C.M. , Wagner K.L. , Burton L.E.
      Arch. Biochem. Biophys.302:484-489(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT ASN-31; ASN-56; ASN-85; ASN-95; ASN-118 AND ASN-138
    12. 12.
      "Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130."
      Boulanger M.J. , Bankovich A.J. , Kortemme T. , Baker D. , Garcia K.C.
      Mol. Cell12:577-589(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 34-202 IN COMPLEX WITH IL6ST
    13. 13.
      "An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor."
      Huyton T. , Zhang J.G. , Luo C.S. , Lou M.Z. , Hilton D.J. , Nicola N.A. , Garrett T.P.
      Proc. Natl. Acad. Sci. U.S.A.104:12737-12742(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 23-202 IN COMPLEX WITH MOUSE LIFR
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