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Index > Protein center > LMAN1(Gene name) > Human
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  • LMAN1 (Gene name),
  • Protein ERGIC-53 (Protein name ),  LMAN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    LMAN1(ERGIC53;F5F8D);
    Protein name:
    Protein ERGIC-53;
    Alternative:
    Gp58;ER-Golgi intermediate compartment 53 kDa protein;Lectin mannose-binding 1;Intracellular mannose-specific lectin MR60;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2.
    Function:
    Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
    Subcellular Location:
    Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    510
    Sequence:
    50:
    MAGSRQRGLR | ARVRPLFCAL | LLSLGRFVRG | DGVGGDPAVA | LPHRRFEYKY | 
    100:
    SFKGPHLVQS | DGTVPFWAHA | GNAIPSSDQI | RVAPSLKSQR | GSVWTKTKAA | 
    150:
    FENWEVEVTF | RVTGRGRIGA | DGLAIWYAEN | QGLEGPVFGS | ADLWNGVGIF | 
    200:
    FDSFDNDGKK | NNPAIVIIGN | NGQIHYDHQN | DGASQALASC | QRDFRNKPYP | 
    250:
    VRAKITYYQN | TLTVMINNGF | TPDKNDYEFC | AKVENMIIPA | QGHFGISAAT | 
    300:
    GGLADDHDVL | SFLTFQLTEP | GKEPPTPDKE | ISEKEKEKYQ | EEFEHFQQEL | 
    350:
    DKKKEEFQKG | HPDLQGQPAE | EIFESVGDRE | LRQVFEGQNR | IHLEIKQLNR | 
    400:
    QLDMILDEQR | RYVSSLTEEI | SKRGAGMPGQ | HGQITQQELD | TVVKTQHEIL | 
    450:
    RQVNEMKNSM | SETVRLVSGM | QHPGSAGGVY | ETTQHFIDIK | EHLHIVKRDI | 
    500:
    DNLVQRNMPS | NEKPKCPELP | PFPSCLSTVH | FIIFVVVQTV | LFIGYIMYRS | 
    510:
    QQEAAAKKFF | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein ERGIC-53
    Cat.:
    E9737m
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Protein ERGIC-53
    Cat.:
    E9737r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Protein ERGIC-53
    Cat.:
    E9737h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Protein ERGIC-53
    Cat.:
    U9737h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Protein ERGIC-53
    Cat.:
    U9737r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein ERGIC-53
    Cat.:
    U9737m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Protein ERGIC-53
    Cat.:
    P9737Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein ERGIC-53
    Cat.:
    P9737Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein ERGIC-53
    Monoclonal Antibody for Human Protein ERGIC-53
    Monoclonal Antibody for Human Protein ERGIC-53
    Monoclonal Antibody for Human Protein ERGIC-53
    Protein for Human Protein ERGIC-53
    Protein for Human Protein ERGIC-53
    Protein for Human Protein ERGIC-53

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif."
      Schindler R. , Itin C. , Zerial M. , Lottspeich F. , Hauri H.-P.
      Eur. J. Cell Biol.61:1-9(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-59 AND 418-432
      tissue: Liver.
      tissue: Placenta.
    2. 2.
      "ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells."
      Arar C. , Carpentier V. , Le Caer J.-P. , Monsigny M. , Legrand A. , Roche A.-C.
      J. Biol. Chem.270:3551-3553(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-41
      tissue: Peripheral blood.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-14; ALA-39 AND LEU-410;INVOLVEMENT IN F5F8D1
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-410
      tissue: Brain.
    5. 5.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-44
      tissue: Platelet.
    6. 6.
      "A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins."
      Fiedler K. , Simons K.
      Cell77:625-626(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO LEGUMINOUS LECTINS
    7. 7.
      "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
      Harris R.A. , Yang A. , Stein R.C. , Lucy K. , Brusten L. , Herath A. , Parekh R. , Waterfield M.D. , O'Hare M.J. , Neville M.A. , Page M.J. , Zvelebil M.J.
      Proteomics2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
      tissue: Mammary cancer.
    8. 8.
      "ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains."
      Nufer O. , Kappeler F. , Guldbrandsen S. , Hauri H.-P.
      J. Cell Sci.116:4429-4440(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MOTIF ER EXPORT;DISULFIDE BOND
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MCFD2;FUNCTION
    10. 10.
      "Oligomerization and intracellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds."
      Neve E.P. , Lahtinen U. , Pettersson R.F.
      J. Mol. Biol.354:556-568(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT;INTERCHAIN DISULFIDE BONDS
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport."
      Ong Y.S. , Tran T.H. , Gounko N.V. , Hong W.
      J. Cell Sci.127:2825-2839(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMEM115
    13. 13.
      "Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII."
      Wigren E. , Bourhis J.M. , Kursula I. , Guy J.E. , Lindqvist Y.
      FEBS Lett.584:878-882(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 32-277 IN COMPLEX WITH MCFD2 AND CALCIUM IONS;SUBUNIT;DISULFIDE BOND
    14. 14.
      "Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency."
      Nishio M. , Kamiya Y. , Mizushima T. , Wakatsuki S. , Sasakawa H. , Yamamoto K. , Uchiyama S. , Noda M. , McKay A.R. , Fukui K. , Hauri H.P. , Kato K.
      Proc. Natl. Acad. Sci. U.S.A.107:4034-4039(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 31-285 IN COMPLEX WITH CALCIUM IONS;SUBUNIT;DISULFIDE BOND
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