LMAN1 ELISA Kit for Human(Homo sapiens) | EIAab.comLMAN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > LMAN1(Gene name) > Human

LMAN1 (Gene name),

Protein ERGIC-53 (Protein name ), LMAN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

LMAN1(ERGIC53;F5F8D);

Protein name:

Protein ERGIC-53;

Alternative:

Gp58;ER-Golgi intermediate compartment 53 kDa protein;Lectin mannose-binding 1;Intracellular mannose-specific lectin MR60;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Exists both as a covalent disulfide-linked homohexamer, and a complex of three disulfide-linked dimers non-covalently kept together. Interacts with MCFD2.

Function:

Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.

Subcellular Location:

Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

510

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

510:

QQEAAAKKFF |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P49257

UniGene:

Hs.465295

SMR:

P49257

MIM:

227300

Pfam:

PF03388

KEGG:

hsa:3998

Uniprot:

P49257

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ELISA Kit for Human Protein ERGIC-53

Cat.:

E9737m

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96T

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ELISA Kit for Human Protein ERGIC-53

Cat.:

E9737r

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96T

ELISA Kit for Human Protein ERGIC-53

Cat.:

E9737h

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96T

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CLIA Kit for Human Protein ERGIC-53

Cat.:

U9737h

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96T

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CLIA Kit for Human Protein ERGIC-53

Cat.:

U9737r

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96T

CLIA Kit for Human Protein ERGIC-53

Cat.:

U9737m

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96T

Polyclonal Antibody for Human Protein ERGIC-53

Cat.:

P9737Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein ERGIC-53

Cat.:

P9737Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein ERGIC-53

Monoclonal Antibody for Human Protein ERGIC-53

Protein for Human Protein ERGIC-53

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif."
Schindler R. , Itin C. , Zerial M. , Lottspeich F. , Hauri H.-P.
Eur. J. Cell Biol.61:1-9(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-59 AND 418-432
tissue: Liver.
tissue: Placenta.
2.

"ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells."
Arar C. , Carpentier V. , Le Caer J.-P. , Monsigny M. , Legrand A. , Roche A.-C.
J. Biol. Chem.270:3551-3553(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 31-41
tissue: Peripheral blood.
3.

"ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families."
Nichols W.C. , Terry V.H. , Wheatley M.A. , Yang A. , Zivelin A. , Ciavarella N. , Stefanile C. , Matsushita T. , Saito H. , de Bosch N.B. , Ruiz-Saez A. , Torres A. , Thompson A.R. , Feinstein D.I. , White G.C. , Negrier C. , Vinciguerra C. , Aktan M. , more...
Blood93:2261-2266(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-14; ALA-39 AND LEU-410;INVOLVEMENT IN F5F8D1
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-410
tissue: Brain.
5.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-44
tissue: Platelet.
6.

"A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins."
Fiedler K. , Simons K.
Cell77:625-626(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO LEGUMINOUS LECTINS
7.

"Cluster analysis of an extensive human breast cancer cell line protein expression map database."
Harris R.A. , Yang A. , Stein R.C. , Lucy K. , Brusten L. , Herath A. , Parekh R. , Waterfield M.D. , O'Hare M.J. , Neville M.A. , Page M.J. , Zvelebil M.J.
Proteomics2:212-223(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
tissue: Mammary cancer.
8.

"ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains."
Nufer O. , Kappeler F. , Guldbrandsen S. , Hauri H.-P.
J. Cell Sci.116:4429-4440(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MOTIF ER EXPORT;DISULFIDE BOND
9.

"Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex."
Zhang B. , Cunningham M.A. , Nichols W.C. , Bernat J.A. , Seligsohn U. , Pipe S.W. , McVey J.H. , Schulte-Overberg U. , de Bosch N.B. , Ruiz-Saez A. , White G.C. , Tuddenham E.G. , Kaufman R.J. , Ginsburg D.
Nat. Genet.34:220-225(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MCFD2;FUNCTION
10.

"Oligomerization and intracellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds."
Neve E.P. , Lahtinen U. , Pettersson R.F.
J. Mol. Biol.354:556-568(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT;INTERCHAIN DISULFIDE BONDS
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport."
Ong Y.S. , Tran T.H. , Gounko N.V. , Hong W.
J. Cell Sci.127:2825-2839(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMEM115
13.

"Crystal structure of the LMAN1-CRD/MCFD2 transport receptor complex provides insight into combined deficiency of factor V and factor VIII."
Wigren E. , Bourhis J.M. , Kursula I. , Guy J.E. , Lindqvist Y.
FEBS Lett.584:878-882(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 32-277 IN COMPLEX WITH MCFD2 AND CALCIUM IONS;SUBUNIT;DISULFIDE BOND
14.

"Structural basis for the cooperative interplay between the two causative gene products of combined factor V and factor VIII deficiency."
Nishio M. , Kamiya Y. , Mizushima T. , Wakatsuki S. , Sasakawa H. , Yamamoto K. , Uchiyama S. , Noda M. , McKay A.R. , Fukui K. , Hauri H.P. , Kato K.
Proc. Natl. Acad. Sci. U.S.A.107:4034-4039(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 31-285 IN COMPLEX WITH CALCIUM IONS;SUBUNIT;DISULFIDE BOND

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