ALOX12 ELISA Kit for Human(Homo sapiens) | EIAab.comALOX12 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ALOX12(Gene name) > Human

ALOX12 (Gene name),

Arachidonate 12-lipoxygenase, 12S-type (Protein name ), LOX12_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ALOX12(LOG12;LOG12);

Protein name:

Arachidonate 12-lipoxygenase, 12S-type(12S-LOX;12S-lipoxygenase);

Alternative:

Platelet-type lipoxygenase 12;3.3.2.-;Platelet-type lipoxygenase 12);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

Oxygenase and 14,15-leukotriene A4 synthase activity.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

663

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

663:

YLKPSCIENS | VTI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00305

SMR:

P18054

UniGene:

Hs.654431

KEGG:

hsa:239

String:

P18054

MIM:

114500

STRING:

9606.ENSP00000251535

MIM:

152391

Uniprot:

P18054

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ELISA Kit for Human 12S-LOX

Cat.:

E1965h

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96T

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ELISA Kit for Human 12S-LOX

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E1965b

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96T

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ELISA Kit for Human 12S-LOX

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E1965m

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96T

ELISA Kit for Human 12S-LOX

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E1965p

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96T

ELISA Kit for Human 12S-LOX

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E1965r

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96T

ELISA Kit for Human 12S-LOX

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CLIA Kit for Human 12S-LOX

Cat.:

U1965r

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96T

CLIA Kit for Human 12S-LOX

Cat.:

U1965h

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MSDS:

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Packing:

96T

CLIA Kit for Human 12S-LOX

Cat.:

U1965m

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MSDS:

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Packing:

96T

CLIA Kit for Human 12S-LOX

Cat.:

U1965b

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MSDS:

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Packing:

96T

CLIA Kit for Human 12S-LOX

Cat.:

U1965p

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Packing:

96T

CLIA Kit for Human 12S-LOX

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Polyclonal Antibody for Human 12S-LOX

Cat.:

P1965Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human 12S-LOX

Cat.:

P1965Rb-h

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Polyclonal Antibody for Human 12S-LOX

Cat.:

P1965Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human 12S-LOX

Monoclonal Antibody for Human 12S-LOX

Protein for Human 12S-LOX

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and expression of human arachidonate 12-lipoxygenase."
Yoshimoto T. , Yamamoto Y. , Arakawa T. , Suzuki H. , Yamamoto S. , Yokoyama C. , Tanabe T. , Toh H.
Biochem. Biophys. Res. Commun.172:1230-1235(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-322
2.

"Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase."
Funk C.D. , Furci L. , Fitzgerald G.A.
Proc. Natl. Acad. Sci. U.S.A.87:5638-5642(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-322
3.

"Cloning of the cDNA for human 12-lipoxygenase."
Izumi T. , Hoshiko S. , Raadmark O. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.87:7477-7481(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ARG-261
4.

SeattleSNPs variation discovery resource
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-261; SER-322 AND HIS-430
5.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-261
7.

"Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene."
Yoshimoto T. , Arakawa T. , Hada T. , Yamamoto S. , Takahashi E.
J. Biol. Chem.267:24805-24809(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112
8.

"Characterization of human 12-lipoxygenase genes."
Funk C.D. , Funk L.B. , Fitzgerald G.A. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.89:3962-3966(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45
9.

"Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis."
Hussain H. , Shornick L.P. , Shannon V.R. , Wilson J.D. , Funk C.D. , Pentland A.P. , Holtzman M.J.
Am. J. Physiol.266:C243-C253(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 340-427
tissue: Skin.
10.

"EU-IMAGE: full-insert length sequencing of human cDNA clones."
Persson A.E. , Lundeberg J. , Uhlen M.
Submitted (1999-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 531-663
11.

"Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins."
Hada T. , Ueda N. , Takahashi Y. , Yamamoto S.
Biochim. Biophys. Acta1083:89-93(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;KINETIC PARAMETERS;PATHWAY;SUBSTRATE SPECIFICITY
12.

"Lipoxin synthase activity of human platelet 12-lipoxygenase."
Romano M. , Chen X.S. , Takahashi Y. , Yamamoto S. , Funk C.D. , Serhan C.N.
Biochem. J.296:127-133(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LIPOXIN SYNTHESIS;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;REACTION MECHANISM
13.

"Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system."
Chen X.S. , Brash A.R. , Funk C.D.
Eur. J. Biochem.214:845-852(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;KINETIC PARAMETERS;PH DEPENDENCE;SUBCELLULAR LOCATION
14.

"Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies."
Chen X.S. , Funk C.D.
FASEB J.7:694-701(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;MUTAGENESIS OF HIS-355; HIS-360; HIS-365; HIS-383; HIS-392; LYS-416; ALA-417; VAL-418 AND HIS-540
15.

"12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization."
Hagmann W. , Gao X. , Timar J. , Chen Y.Q. , Strohmaier A.R. , Fahrenkopf C. , Kagawa D. , Lee M. , Zacharek A. , Honn K.V.
Exp. Cell Res.228:197-205(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ENZYME REGULATION;INDUCTION
16.

"Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth."
Nie D. , Hillman G.G. , Geddes T. , Tang K. , Pierson C. , Grignon D.J. , Honn K.V.
Cancer Res.58:4047-4051(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
17.

"Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells."
Nie D. , Krishnamoorthy S. , Jin R. , Tang K. , Chen Y. , Qiao Y. , Zacharek A. , Guo Y. , Milanini J. , Pages G. , Honn K.V.
J. Biol. Chem.281:18601-18609(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
18.

"Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes."
Yoo H. , Jeon B. , Jeon M.S. , Lee H. , Kim T.Y.
FEBS Lett.582:3249-3253(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY UV
19.

"Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells."
Klampfl T. , Bogner E. , Bednar W. , Mager L. , Massudom D. , Kalny I. , Heinzle C. , Berger W. , Staettner S. , Karner J. , Klimpfinger M. , Fuerstenberger G. , Krieg P. , Marian B.
Exp. Cell Res.318:768-778(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION
20.

"12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival."
Weisinger G. , Grafi-Cohen M. , Hirsh M. , Knoll E. , Sharon O. , Many A. , Limor R. , Stern N.
Exp. Cell Res.319:1586-1593(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOTIC PROCESS;TISSUE SPECIFICITY
21.

"Crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12s-type."
Structural genomics consortium (SGC)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 172-662 IN COMPLEX WITH IRON IONS
22.

"Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
Goodman J.E. , Bowman E.D. , Chanock S.J. , Alberg A.J. , Harris C.C.
Carcinogenesis25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-261
23.

"Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer."
Tan W. , Wu J. , Zhang X. , Guo Y. , Liu J. , Sun T. , Zhang B. , Zhao D. , Yang M. , Yu D. , Lin D.
Carcinogenesis28:1197-1201(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-261;INVOLVEMENT IN COLORECTAL CANCER
24.

"Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms."
Guo Y. , Zhang X. , Tan W. , Miao X. , Sun T. , Zhao D. , Lin D.
Pharmacogenet. Genomics17:197-205(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-261;INVOLVEMENT IN ESOPHAGEAL CANCER

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