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Index > Protein center > ALOX15(Gene name) > Human
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  • ALOX15 (Gene name),
  • Arachidonate 15-lipoxygenase (Protein name ),  LOX15_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ALOX15(LOG15);
    Protein name:
    Arachidonate 15-lipoxygenase(15-LOX);
    Alternative:
    Arachidonate omega-6 lipoxygenase;Arachidonate omega-6 lipoxygenase;1.13.11.31;Arachidonate 12-lipoxygenase, leukocyte-type(12-LOX);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid. Also acts on C-12 of arachidonate as well as on linoleic acid.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    662
    Sequence:
    50:
    MGLYRIRVST | GASLYAGSNN | QVQLWLVGQH | GEAALGKRLW | PARGKETELK | 
    100:
    VEVPEYLGPL | LFVKLRKRHL | LKDDAWFCNW | ISVQGPGAGD | EVRFPCYRWV | 
    150:
    EGNGVLSLPE | GTGRTVGEDP | QGLFQKHREE | ELEERRKLYR | WGNWKDGLIL | 
    200:
    NMAGAKLYDL | PVDERFLEDK | RVDFEVSLAK | GLADLAIKDS | LNVLTCWKDL | 
    250:
    DDFNRIFWCG | QSKLAERVRD | SWKEDALFGY | QFLNGANPVV | LRRSAHLPAR | 
    300:
    LVFPPGMEEL | QAQLEKELEG | GTLFEADFSL | LDGIKANVIL | CSQQHLAAPL | 
    350:
    VMLKLQPDGK | LLPMVIQLQL | PRTGSPPPPL | FLPTDPPMAW | LLAKCWVRSS | 
    400:
    DFQLHELQSH | LLRGHLMAEV | IVVATMRCLP | SIHPIFKLII | PHLRYTLEIN | 
    450:
    VRARTGLVSD | MGIFDQIMST | GGGGHVQLLK | QAGAFLTYSS | FCPPDDLADR | 
    500:
    GLLGVKSSFY | AQDALRLWEI | IYRYVEGIVS | LHYKTDVAVK | DDPELQTWCR | 
    550:
    EITEIGLQGA | QDRGFPVSLQ | ARDQVCHFVT | MCIFTCTGQH | ASVHLGQLDW | 
    600:
    YSWVPNAPCT | MRLPPPTTKD | ATLETVMATL | PNFHQASLQM | SITWQLGRRQ | 
    650:
    PVMVAVGQHE | EEYFSGPEPK | AVLKKFREEL | AALDKEIEIR | NAKLDMPYEY | 
    662:
    LRPSVVENSV | AI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    String:
    KEGG:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human 15-LOX
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    E0891h
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    ELISA Kit for Human 15-LOX
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    E0891r
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    ELISA Kit for Human 15-LOX
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    ELISA Kit for Human 15-LOX
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    E0891m
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    ELISA Kit for Human 15-LOX
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    ELISA Kit for Human 15-LOX
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    E0891b
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    Packing:
    96T
    CLIA Kit for Human 15-LOX
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    U0891p
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    CLIA Kit for Human 15-LOX
    Cat.:
    U0891h
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    MSDS:
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    96T
    CLIA Kit for Human 15-LOX
    Cat.:
    U0891r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 15-LOX
    MSDS:
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    CLIA Kit for Human 15-LOX
    Cat.:
    U0891b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 15-LOX
    Cat.:
    U0891m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human 15-LOX
    Cat.:
    P0891Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 15-LOX
    Polyclonal Antibody for Human 15-LOX
    Cat.:
    P0891Rb-h
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 15-LOX
    Polyclonal Antibody for Human 15-LOX
    Cat.:
    P0891Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 15-LOX
    Monoclonal Antibody for Human 15-LOX
    Monoclonal Antibody for Human 15-LOX
    Monoclonal Antibody for Human 15-LOX
    Monoclonal Antibody for Human 15-LOX
    Monoclonal Antibody for Human 15-LOX
    Monoclonal Antibody for Human 15-LOX
    Protein for Human 15-LOX
    Protein for Human 15-LOX
    Protein for Human 15-LOX
    Protein for Human 15-LOX
    Protein for Human 15-LOX
    Protein for Human 15-LOX

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
    2. 2.
      "Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene."
      Kritzik M.R. , Ziober A.F. , Dicharry S. , Conrad D.J. , Sigal E.
      Biochim. Biophys. Acta1352:267-281(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Tongue.
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2003-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-90; LYS-103 AND GLN-205
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-461
      tissue: Brain.
      tissue: Lung.
    6. 7.
      "Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes."
      Kelavkar U. , Wang S. , Montero A. , Murtagh J. , Shah K. , Badr K.
      Mol. Biol. Rep.25:173-182(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46
    7. 8.
      "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases."
      Sigal E. , Grunberger D. , Craik C.S. , Caughey G.H. , Nadel J.A.
      J. Biol. Chem.263:5328-5332(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-16
    8. 9.
      "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes."
      Izumi T. , Raadmark O. , Joernvall H. , Samuelsson B.
      Eur. J. Biochem.202:1231-1238(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-31; 38-45; 157-168 AND 626-631
      tissue: Eosinophil.
      tissue: Leukocyte.
    9. 10.
      "A primary determinant for lipoxygenase positional specificity."
      Sloane D.L. , Leung R. , Craik C.S. , Sigal E.
      Nature354:149-152(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;MUTAGENESIS OF MET-418
    10. 11.
      "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme."
      Brinckmann R. , Schnurr K. , Heydeck D. , Rosenbach T. , Kolde G. , Kuehn H.
      Blood91:64-74(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    11. 12.
      "Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells."
      Hsi L.C. , Kamitani H. , Cornicelli J.A. , Eling T.E.
      Prostaglandins Leukot. Essent. Fatty Acids64:217-225(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    12. 13.
      "Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity."
      Andersson E. , Schain F. , Svedling M. , Claesson H.E. , Forsell P.K.
      Biochim. Biophys. Acta1761:1498-1505(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIPID-BINDING;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;FUNCTION;ENZYME REGULATION
    13. 14.
      "Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes."
      Yoo H. , Jeon B. , Jeon M.S. , Lee H. , Kim T.Y.
      FEBS Lett.582:3249-3253(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY UV
    14. 15.
      "15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism."
      Weibel G.L. , Joshi M.R. , Wei C. , Bates S.R. , Blair I.A. , Rothblat G.H.
      J. Lipid Res.50:2371-2376(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    15. 16.
      "15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells."
      Zhao J. , O'Donnell V.B. , Balzar S. , St Croix C.M. , Trudeau J.B. , Wenzel S.E.
      Proc. Natl. Acad. Sci. U.S.A.108:14246-14251(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN IL13 SIGNALING;INTERACTION WITH PEBP1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    16. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-560;CHARACTERIZATION OF VARIANT MET-560;INVOLVEMENT IN CORONARY ARTERY DISEASE
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