ALOX5 ELISA Kit for Human(Homo sapiens) | EIAab.comALOX5 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > ALOX5(Gene name) > Human

ALOX5 (Gene name),

Arachidonate 5-lipoxygenase (Protein name ), LOX5_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

ALOX5(LOG5);

Protein name:

Arachidonate 5-lipoxygenase(5-LO;5-lipoxygenase);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ALOX5AP and LTC4S.

Function:

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.

Subcellular Location:

Cytoplasm Nucleus matrix Nucleus membrane Peripheral membrane protein Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Protein Attributes:

Sequence length:

674

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

674:

ERNKKKQLPY | YYLSPDRIPN | SVAI

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF00305

String:

P09917

MIM:

152390

SMR:

P09917

STRING:

9606.ENSP00000363512

UniGene:

Hs.89499

KEGG:

hsa:240

Uniprot:

P09917

FOR

ELISA Kit for Human 5-LO

Cat.:

E1355h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human 5-LO

Cat.:

E1355m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human 5-LO

Cat.:

E1355r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human 5-LO

Cat.:

U1355r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human 5-LO

Cat.:

U1355m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human 5-LO

Cat.:

U1355h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human 5-LO

Cat.:

P1355Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human 5-LO

Cat.:

P1355Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human 5-LO

Cat.:

P1355Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human 5-LO

Protein for Human 5-LO

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of the cDNA for human 5-lipoxygenase."
Dixon R.A.F. , Jones R.E. , Diehl R.E. , Bennett C.D. , Kargman S. , Rouzer C.A.
Proc. Natl. Acad. Sci. U.S.A.85:416-420(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
2.

"Molecular cloning and amino acid sequence of human 5-lipoxygenase."
Matsumoto T. , Funk C.D. , Raadmark O. , Hoeoeg J.-O. , Joernvall H. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.85:26-30(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

Matsumoto T. , Funk C.D. , Raadmark O. , Hoeoeg J.-O. , Joernvall H. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.85:3406-3406(1988)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Molecular cloning and amino acid sequence of human 5-lipoxygenase."
Matsumoto T. , Funk C.D. , Raadmark O. , Hoeoeg J.-O. , Joernvall H. , Samuelsson B.
Adv. Prostaglandin Thromboxane Leukotriene Res.19:466-469(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
5.

"Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products."
Boudreau L.H. , Bertin J. , Robichaud P.P. , Laflamme M. , Ouellette R.J. , Flamand N. , Surette M.E.
FASEB J.25:1097-1105(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5)
6.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
8.

"Characterization of the human 5-lipoxygenase gene."
Funk C.D. , Hoshiko S. , Matsumoto T. , Raadmark O. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.86:2587-2591(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50
9.

"Characterization of the human 5-lipoxygenase gene promoter."
Hoshiko S. , Raadmark O. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.87:9073-9077(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11
10.

"Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase."
Rouzer C.A. , Samuelsson B.
Proc. Natl. Acad. Sci. U.S.A.84:7393-7397(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase."
Nguyen T. , Falgueyret J.-P. , Abramowitz M. , Riendeau D.
J. Biol. Chem.266:22057-22062(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-363; HIS-368; HIS-373; HIS-391 AND HIS-400
12.

"Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase."
Ishii S. , Noguchi M. , Miyano M. , Matsumoto T. , Noma M.
Biochem. Biophys. Res. Commun.182:1482-1490(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-368; HIS-373; GLU-377; HIS-391; HIS-400 AND HIS-551
13.

"5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes."
Woods J.W. , Evans J.F. , Ethier D. , Scott S. , Vickers P.J. , Hearn L. , Heibein J.A. , Charleson S. , Singer I.I.
J. Exp. Med.178:1935-1946(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
14.

"Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)."
Werz O. , Szellas D. , Steinhilber D. , Radmark O.
J. Biol. Chem.277:14793-14800(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-272
15.

"Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523."
Luo M. , Jones S.M. , Phare S.M. , Coffey M.J. , Peters-Golden M. , Brock T.G.
J. Biol. Chem.279:41512-41520(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-524;MUTAGENESIS OF SER-524
16.

"Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils."
Flamand N. , Lefebvre J. , Surette M.E. , Picard S. , Borgeat P.
J. Biol. Chem.281:129-136(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
17.

"Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein."
Strid T. , Svartz J. , Franck N. , Hallin E. , Ingelsson B. , Soederstroem M. , Hammarstroem S.
Biochem. Biophys. Res. Commun.381:518-522(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ALOX5AP AND LTC4S;SUBCELLULAR LOCATION
18.

"Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export."
Flamand N. , Luo M. , Peters-Golden M. , Brock T.G.
J. Biol. Chem.284:306-313(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-272;MUTAGENESIS OF SER-272
19.

"Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102."
Esser J. , Rakonjac M. , Hofmann B. , Fischer L. , Provost P. , Schneider G. , Steinhilber D. , Samuelsson B. , Radmark O.
Biochem. J.425:265-274(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COTL1;MUTAGENESIS OF TRP-103
20.

"The structure of human 5-lipoxygenase."
Gilbert N.C. , Bartlett S.G. , Waight M.T. , Neau D.B. , Boeglin W.E. , Brash A.R. , Newcomer M.E.
Science331:217-219(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH IRON ION;COFACTOR;CATALYTIC ACTIVITY;FUNCTION
21.

"Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."
Goodman J.E. , Bowman E.D. , Chanock S.J. , Alberg A.J. , Harris C.C.
Carcinogenesis25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-254

Product Feedback Wall

* Email:
*Comments: